Diabetic retinopathy: Current and future methods for early screening from a retinal hemodynamic and geometric approach

Georgios Leontidis*, Bashir Al-Diri, Andrew Hunter

*Corresponding author for this work

Research output: Contribution to journalReview article

11 Citations (Scopus)

Abstract

Diabetic retinopathy (DR) is a major disease and is the number one cause of blindness in the UK. In England alone, 4200 new cases appear every year and 1280 lead to blindness. DR is a result of diabetes mellitus, which affects the retina of the eye and specifically the vessel structure. Elevated levels of glucose cause a malfunction in the cell structure, which affects the vessel wall and, in severe conditions, leads to their breakage. Much research has been carried out on detecting the different stages of DR but not enough versatile research has been carried out on the detection of early DR before the appearance of any lesions. In this review, the authors approach the topic from the functional side of the human eye and how hemodynamic factors that are impaired by diabetes affect the vascular structure.

Original languageEnglish
Pages (from-to)431-442
Number of pages12
JournalExpert Review of Ophthalmology
Volume9
Issue number5
Early online date4 Aug 2014
DOIs
Publication statusPublished - 2014

Keywords

  • diabetes mellitus
  • diabetic retinopathy
  • diagnosis
  • geometric feature
  • hemodynamic
  • microcirculation
  • retina

ASJC Scopus subject areas

  • Biomedical Engineering
  • Ophthalmology

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