Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 1358-1364 |
| Number of pages | 7 |
| Journal | Journal of Natural Products |
| Volume | 71 |
| Issue number | 8 |
| Early online date | 2 Aug 2008 |
| DOIs | |
| Publication status | Published - Aug 2008 |
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Diacarperoxides, norterpene cyclic peroxides from the sponge Diacarnus megaspinorhabdosa. / Ibrahim, S.R.M.; Ebel, R.; Wray, V.; Müller, W.E.G.; Edrada-Ebel, R.; Proksch, P.
In: Journal of Natural Products, Vol. 71, No. 8, 08.2008, p. 1358-1364.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Diacarperoxides, norterpene cyclic peroxides from the sponge Diacarnus megaspinorhabdosa
AU - Ibrahim, S.R.M.
AU - Ebel, R.
AU - Wray, V.
AU - Müller, W.E.G.
AU - Edrada-Ebel, R.
AU - Proksch, P.
N1 - MEDLINE® is the source for the MeSH terms of this document.
PY - 2008/8
Y1 - 2008/8
N2 - Chemical investigation of the hexane extract of the sponge Diacarnus megaspinorhabdosa provided a series of new norterpene derivatives including three norditerpene cyclic peroxides, diacarperoxides A, B, and C (1 to 3), four norsesterterpene cyclic peroxides, diacarperoxides D to G (4 to 7), and the acyclic norsesterterpene diacardiol A (8). In addition, known norterpene peroxide congeners were also isolated, which included a known norsesterterpene cyclic peroxide (9), nuapapuin A methyl ester (10), epimuqubilin B (11), methyl-2-epinuapapuinoate (12), and methyl diacarnoate A (13). The structures of the new compounds were established on the basis of one- and two-dimensional NMR spectroscopic studies (H, C, COSY, HMQC, HMBC, and ROESY) as well as by mass spectrometric analyses. The relative configuration of chiral centers at C-2, C-3, and C-6 was assigned by established empirical rules. All compounds were evaluated for their cytotoxic properties in vitro using several human as well as murine cancer cell lines.
AB - Chemical investigation of the hexane extract of the sponge Diacarnus megaspinorhabdosa provided a series of new norterpene derivatives including three norditerpene cyclic peroxides, diacarperoxides A, B, and C (1 to 3), four norsesterterpene cyclic peroxides, diacarperoxides D to G (4 to 7), and the acyclic norsesterterpene diacardiol A (8). In addition, known norterpene peroxide congeners were also isolated, which included a known norsesterterpene cyclic peroxide (9), nuapapuin A methyl ester (10), epimuqubilin B (11), methyl-2-epinuapapuinoate (12), and methyl diacarnoate A (13). The structures of the new compounds were established on the basis of one- and two-dimensional NMR spectroscopic studies (H, C, COSY, HMQC, HMBC, and ROESY) as well as by mass spectrometric analyses. The relative configuration of chiral centers at C-2, C-3, and C-6 was assigned by established empirical rules. All compounds were evaluated for their cytotoxic properties in vitro using several human as well as murine cancer cell lines.
UR - http://www.scopus.com/inward/record.url?scp=51849109849&partnerID=8YFLogxK
U2 - 10.1021/np800102u
DO - 10.1021/np800102u
M3 - Article
VL - 71
SP - 1358
EP - 1364
JO - Journal of Natural Products
JF - Journal of Natural Products
SN - 0163-3864
IS - 8
ER -