Diagnostic salivary biomarkers in oral cancer and oral potentially malignant disorders and their relationships to risk factors ?: A systematic review

Nadisha Sewwandi Piyarathne; R.M.S.G.K  Rasnayake; Randilini  Angammana; Pushpika  Chandrasekera; Samantha Ramachandra; Manjula  Weerasekera; Surangi  Yasawardene; Rasha Abu Eid; Jaya Jayasinghe; Ekta Gupta

doi:10.1080/14737159.2021.1944106

Diagnostic salivary biomarkers in oral cancer and oral potentially malignant disorders and their relationships to risk factors ? A systematic review

Nadisha Sewwandi Piyarathne^* (Corresponding Author), R.M.S.G.K Rasnayake, Randilini Angammana, Pushpika Chandrasekera, Samantha Ramachandra, Manjula Weerasekera, Surangi Yasawardene, Rasha Abu Eid, Jaya Jayasinghe, Ekta Gupta

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

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Abstract

Introduction Oral squamous cell carcinoma (OSCC) and oral potentially malignant disorders (OPMD) are a significant health burden globally. Smoking, alcohol, and betel quid are the main risk factors. Lack of screening methods has been highlighted as a significant challenge in management. Salivary biomarkers are proposed as noninvasive diagnostic tools. The aim of this systematic review was to study salivary biomarkers reported in OSCC and OPMD. Specific objectives were to select a salivary biomarker panel suitable for early detection of OSCC and OPMD and to assess relationships between salivary biomarkers and risk factors. Methods Electronic literature search was conducted in academic databases (Scopus, Medline, Embase and Web of Science) without any restrictions. Following calibration, two blinded reviewers screened the studies and extracted data. A risk of bias assessment was conducted using Newcastle Ottawa scale. 295 studies were included with descriptive data analysis. Expert opinion A salivary biomarker panel including Interleukin (IL) 1 beta, IL6, and IL8 was selected for OSCC and OPMD. Reported relationships between salivary biomarkers and risk factors are discussed and research gaps are highlighted. Future research should be directed to assess potential salivary biomarkers and their relationships to risk factors in order to understand the biomarker's role in disease initiation.

Original language	English
Pages (from-to)	789-807
Number of pages	19
Journal	Expert Review of Molecular Diagnostics
Volume	21
Issue number	8
Early online date	12 Jul 2021
DOIs	https://doi.org/10.1080/14737159.2021.1944106
Publication status	Published - 2021

Bibliographical note

Acknowledgements
NP was financially supported by University of Aberdeen (Elphinstone scholarship) and University grants commission of Sri Lanka. Authors would like to thank the library staff at Medical library and Sri Duncan Rice library for their support in the literature search and recovery of research articles.

Keywords

Oral squamous cell carcinoma
oral potentially malignant disorders
risk factors
salivary biomarkers

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Cite this

Piyarathne, N. S., Rasnayake, R. M. S. G. K., Angammana, R., Chandrasekera, P., Ramachandra, S., Weerasekera, M., Yasawardene, S., Abu Eid, R., Jayasinghe, J., & Gupta, E. (2021). Diagnostic salivary biomarkers in oral cancer and oral potentially malignant disorders and their relationships to risk factors ? A systematic review. Expert Review of Molecular Diagnostics, 21(8), 789-807. https://doi.org/10.1080/14737159.2021.1944106

Diagnostic salivary biomarkers in oral cancer and oral potentially malignant disorders and their relationships to risk factors ? A systematic review. / Piyarathne, Nadisha Sewwandi (Corresponding Author); Rasnayake, R.M.S.G.K ; Angammana, Randilini et al.
In: Expert Review of Molecular Diagnostics, Vol. 21, No. 8, 2021, p. 789-807.

Research output: Contribution to journal › Article › peer-review

Piyarathne, NS, Rasnayake, RMSGK, Angammana, R, Chandrasekera, P, Ramachandra, S, Weerasekera, M, Yasawardene, S, Abu Eid, R , Jayasinghe, J & Gupta, E 2021, 'Diagnostic salivary biomarkers in oral cancer and oral potentially malignant disorders and their relationships to risk factors ? A systematic review', Expert Review of Molecular Diagnostics, vol. 21, no. 8, pp. 789-807. https://doi.org/10.1080/14737159.2021.1944106

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abstract = "Introduction Oral squamous cell carcinoma (OSCC) and oral potentially malignant disorders (OPMD) are a significant health burden globally. Smoking, alcohol, and betel quid are the main risk factors. Lack of screening methods has been highlighted as a significant challenge in management. Salivary biomarkers are proposed as noninvasive diagnostic tools. The aim of this systematic review was to study salivary biomarkers reported in OSCC and OPMD. Specific objectives were to select a salivary biomarker panel suitable for early detection of OSCC and OPMD and to assess relationships between salivary biomarkers and risk factors. Methods Electronic literature search was conducted in academic databases (Scopus, Medline, Embase and Web of Science) without any restrictions. Following calibration, two blinded reviewers screened the studies and extracted data. A risk of bias assessment was conducted using Newcastle Ottawa scale. 295 studies were included with descriptive data analysis. Expert opinion A salivary biomarker panel including Interleukin (IL) 1 beta, IL6, and IL8 was selected for OSCC and OPMD. Reported relationships between salivary biomarkers and risk factors are discussed and research gaps are highlighted. Future research should be directed to assess potential salivary biomarkers and their relationships to risk factors in order to understand the biomarker's role in disease initiation.",

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AU - Piyarathne, Nadisha Sewwandi

AU - Rasnayake, R.M.S.G.K

AU - Angammana, Randilini

AU - Chandrasekera, Pushpika

AU - Ramachandra, Samantha

AU - Weerasekera, Manjula

AU - Yasawardene, Surangi

AU - Abu Eid, Rasha

AU - Jayasinghe, Jaya

AU - Gupta, Ekta

N1 - Acknowledgements NP was financially supported by University of Aberdeen (Elphinstone scholarship) and University grants commission of Sri Lanka. Authors would like to thank the library staff at Medical library and Sri Duncan Rice library for their support in the literature search and recovery of research articles.

PY - 2021

Y1 - 2021

N2 - Introduction Oral squamous cell carcinoma (OSCC) and oral potentially malignant disorders (OPMD) are a significant health burden globally. Smoking, alcohol, and betel quid are the main risk factors. Lack of screening methods has been highlighted as a significant challenge in management. Salivary biomarkers are proposed as noninvasive diagnostic tools. The aim of this systematic review was to study salivary biomarkers reported in OSCC and OPMD. Specific objectives were to select a salivary biomarker panel suitable for early detection of OSCC and OPMD and to assess relationships between salivary biomarkers and risk factors. Methods Electronic literature search was conducted in academic databases (Scopus, Medline, Embase and Web of Science) without any restrictions. Following calibration, two blinded reviewers screened the studies and extracted data. A risk of bias assessment was conducted using Newcastle Ottawa scale. 295 studies were included with descriptive data analysis. Expert opinion A salivary biomarker panel including Interleukin (IL) 1 beta, IL6, and IL8 was selected for OSCC and OPMD. Reported relationships between salivary biomarkers and risk factors are discussed and research gaps are highlighted. Future research should be directed to assess potential salivary biomarkers and their relationships to risk factors in order to understand the biomarker's role in disease initiation.

AB - Introduction Oral squamous cell carcinoma (OSCC) and oral potentially malignant disorders (OPMD) are a significant health burden globally. Smoking, alcohol, and betel quid are the main risk factors. Lack of screening methods has been highlighted as a significant challenge in management. Salivary biomarkers are proposed as noninvasive diagnostic tools. The aim of this systematic review was to study salivary biomarkers reported in OSCC and OPMD. Specific objectives were to select a salivary biomarker panel suitable for early detection of OSCC and OPMD and to assess relationships between salivary biomarkers and risk factors. Methods Electronic literature search was conducted in academic databases (Scopus, Medline, Embase and Web of Science) without any restrictions. Following calibration, two blinded reviewers screened the studies and extracted data. A risk of bias assessment was conducted using Newcastle Ottawa scale. 295 studies were included with descriptive data analysis. Expert opinion A salivary biomarker panel including Interleukin (IL) 1 beta, IL6, and IL8 was selected for OSCC and OPMD. Reported relationships between salivary biomarkers and risk factors are discussed and research gaps are highlighted. Future research should be directed to assess potential salivary biomarkers and their relationships to risk factors in order to understand the biomarker's role in disease initiation.

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