Diet and risk factors for age-related maculopathy

Eamonn D. O'Connell, John M. Nolan, Jim Stack, David Greenberg, Janet Kyle, LeighAnne Maddock, Stephen Beatty

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Background: Evidence continues to accumulate that oxidative stress is etiologically important in the pathogenesis of age-related maculopathy (ARM) and that appropriate antioxidants of dietary origin may protect against this condition.

Objective: Risk factors for ARM may be classed as established or putative. We report a study designed to investigate whether such risk factors are associated with a dietary lack of antioxidants relevant to retinal health.

Design: Dietary, anthropometric, and sociodemographic details relating to 828 healthy Irish subjects aged 20-60 y were recorded in a cross-sectional fashion and analyzed for associations between risk factors for ARM and dietary intake of relevant nutrients.

Results: Of the established risk factors for ARM, increasing age was associated with a relative lack of dietary zeaxanthin (P < 0.05) and tobacco use with a relative lack of dietary vitamin C (P < 0.05). Of the putative risk factors for ARM, alcohol consumption was associated with a relative lack of dietary a-linoleic acid (P < 0.05), and female sex was associated with a relative lack of dietary zinc (P < 0.05).

Conclusions: We showed that several variables related to risk for ARM are associated with a relative dietary lack of key nutrients. Our finding that age, the most important and universal risk factor for ARM, is associated with a relative lack of dietary zeaxanthin, is an important finding that warrants further investigation.

Original languageEnglish
Pages (from-to)712-722
Number of pages11
JournalThe American Journal of Clinical Nutrition
Volume87
Issue number3
Publication statusPublished - Mar 2008

Keywords

  • age-related macular degeneration
  • age-related maculopathy
  • antioxidants
  • lutein
  • n-3 fatty acids
  • zeaxanthin
  • beaver dam eye
  • food-frequency questionnaire
  • blue-mountains eye
  • nutrition examination survey
  • senile macular degeneration
  • pigment optical-density
  • 3rd national health
  • 5-year incidence
  • Japanese population
  • seasonal-variation

Cite this

O'Connell, E. D., Nolan, J. M., Stack, J., Greenberg, D., Kyle, J., Maddock, L., & Beatty, S. (2008). Diet and risk factors for age-related maculopathy. The American Journal of Clinical Nutrition, 87(3), 712-722.

Diet and risk factors for age-related maculopathy. / O'Connell, Eamonn D.; Nolan, John M.; Stack, Jim; Greenberg, David; Kyle, Janet; Maddock, LeighAnne; Beatty, Stephen.

In: The American Journal of Clinical Nutrition, Vol. 87, No. 3, 03.2008, p. 712-722.

Research output: Contribution to journalArticle

O'Connell, ED, Nolan, JM, Stack, J, Greenberg, D, Kyle, J, Maddock, L & Beatty, S 2008, 'Diet and risk factors for age-related maculopathy', The American Journal of Clinical Nutrition, vol. 87, no. 3, pp. 712-722.
O'Connell ED, Nolan JM, Stack J, Greenberg D, Kyle J, Maddock L et al. Diet and risk factors for age-related maculopathy. The American Journal of Clinical Nutrition. 2008 Mar;87(3):712-722.
O'Connell, Eamonn D. ; Nolan, John M. ; Stack, Jim ; Greenberg, David ; Kyle, Janet ; Maddock, LeighAnne ; Beatty, Stephen. / Diet and risk factors for age-related maculopathy. In: The American Journal of Clinical Nutrition. 2008 ; Vol. 87, No. 3. pp. 712-722.
@article{f981ef357ded43a89869e1514b40dac6,
title = "Diet and risk factors for age-related maculopathy",
abstract = "Background: Evidence continues to accumulate that oxidative stress is etiologically important in the pathogenesis of age-related maculopathy (ARM) and that appropriate antioxidants of dietary origin may protect against this condition.Objective: Risk factors for ARM may be classed as established or putative. We report a study designed to investigate whether such risk factors are associated with a dietary lack of antioxidants relevant to retinal health.Design: Dietary, anthropometric, and sociodemographic details relating to 828 healthy Irish subjects aged 20-60 y were recorded in a cross-sectional fashion and analyzed for associations between risk factors for ARM and dietary intake of relevant nutrients.Results: Of the established risk factors for ARM, increasing age was associated with a relative lack of dietary zeaxanthin (P < 0.05) and tobacco use with a relative lack of dietary vitamin C (P < 0.05). Of the putative risk factors for ARM, alcohol consumption was associated with a relative lack of dietary a-linoleic acid (P < 0.05), and female sex was associated with a relative lack of dietary zinc (P < 0.05).Conclusions: We showed that several variables related to risk for ARM are associated with a relative dietary lack of key nutrients. Our finding that age, the most important and universal risk factor for ARM, is associated with a relative lack of dietary zeaxanthin, is an important finding that warrants further investigation.",
keywords = "age-related macular degeneration, age-related maculopathy, antioxidants, lutein, n-3 fatty acids, zeaxanthin, beaver dam eye, food-frequency questionnaire, blue-mountains eye, nutrition examination survey, senile macular degeneration, pigment optical-density, 3rd national health, 5-year incidence, Japanese population, seasonal-variation",
author = "O'Connell, {Eamonn D.} and Nolan, {John M.} and Jim Stack and David Greenberg and Janet Kyle and LeighAnne Maddock and Stephen Beatty",
year = "2008",
month = "3",
language = "English",
volume = "87",
pages = "712--722",
journal = "The American Journal of Clinical Nutrition",
issn = "0002-9165",
publisher = "American Society for Nutrition",
number = "3",

}

TY - JOUR

T1 - Diet and risk factors for age-related maculopathy

AU - O'Connell, Eamonn D.

AU - Nolan, John M.

AU - Stack, Jim

AU - Greenberg, David

AU - Kyle, Janet

AU - Maddock, LeighAnne

AU - Beatty, Stephen

PY - 2008/3

Y1 - 2008/3

N2 - Background: Evidence continues to accumulate that oxidative stress is etiologically important in the pathogenesis of age-related maculopathy (ARM) and that appropriate antioxidants of dietary origin may protect against this condition.Objective: Risk factors for ARM may be classed as established or putative. We report a study designed to investigate whether such risk factors are associated with a dietary lack of antioxidants relevant to retinal health.Design: Dietary, anthropometric, and sociodemographic details relating to 828 healthy Irish subjects aged 20-60 y were recorded in a cross-sectional fashion and analyzed for associations between risk factors for ARM and dietary intake of relevant nutrients.Results: Of the established risk factors for ARM, increasing age was associated with a relative lack of dietary zeaxanthin (P < 0.05) and tobacco use with a relative lack of dietary vitamin C (P < 0.05). Of the putative risk factors for ARM, alcohol consumption was associated with a relative lack of dietary a-linoleic acid (P < 0.05), and female sex was associated with a relative lack of dietary zinc (P < 0.05).Conclusions: We showed that several variables related to risk for ARM are associated with a relative dietary lack of key nutrients. Our finding that age, the most important and universal risk factor for ARM, is associated with a relative lack of dietary zeaxanthin, is an important finding that warrants further investigation.

AB - Background: Evidence continues to accumulate that oxidative stress is etiologically important in the pathogenesis of age-related maculopathy (ARM) and that appropriate antioxidants of dietary origin may protect against this condition.Objective: Risk factors for ARM may be classed as established or putative. We report a study designed to investigate whether such risk factors are associated with a dietary lack of antioxidants relevant to retinal health.Design: Dietary, anthropometric, and sociodemographic details relating to 828 healthy Irish subjects aged 20-60 y were recorded in a cross-sectional fashion and analyzed for associations between risk factors for ARM and dietary intake of relevant nutrients.Results: Of the established risk factors for ARM, increasing age was associated with a relative lack of dietary zeaxanthin (P < 0.05) and tobacco use with a relative lack of dietary vitamin C (P < 0.05). Of the putative risk factors for ARM, alcohol consumption was associated with a relative lack of dietary a-linoleic acid (P < 0.05), and female sex was associated with a relative lack of dietary zinc (P < 0.05).Conclusions: We showed that several variables related to risk for ARM are associated with a relative dietary lack of key nutrients. Our finding that age, the most important and universal risk factor for ARM, is associated with a relative lack of dietary zeaxanthin, is an important finding that warrants further investigation.

KW - age-related macular degeneration

KW - age-related maculopathy

KW - antioxidants

KW - lutein

KW - n-3 fatty acids

KW - zeaxanthin

KW - beaver dam eye

KW - food-frequency questionnaire

KW - blue-mountains eye

KW - nutrition examination survey

KW - senile macular degeneration

KW - pigment optical-density

KW - 3rd national health

KW - 5-year incidence

KW - Japanese population

KW - seasonal-variation

M3 - Article

VL - 87

SP - 712

EP - 722

JO - The American Journal of Clinical Nutrition

JF - The American Journal of Clinical Nutrition

SN - 0002-9165

IS - 3

ER -