Diet-induced obesity in the Sprague-Dawley rat: dietary manipulations and their effect on hypothalamic neuropeptide energy balance systems

Julian Mercer, Z A Archer

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

The SD (Sprague-Dawley) rat model of DIO (diet-induced obesity) is reported to exhibit a clear segregation into susceptible and resistant subpopulations shortly after transfer to a HE (high energy) diet. This does not appear to be the case for rats sourced in the U.K., where body weight gain on obesogenic HE diet is normally distributed, as might be anticipated for a polygenic trait in an outbred population. Many of the energy balance effects of dietary manipulation in this model (e.g. supplementation of HE diet with the liquid diet, Ensure; energy intake and defence of body weight following withdrawal of obesogenic diet) appear to be characteristics of the diets being manipulated rather than subject traits. The activities of energy balance-related hypothalamic signals are affected by diet and the development of DIO, but may not be able to differentiate between different diets and the relative levels of obesity that develop.
Original languageEnglish
Pages (from-to)1068-72
Number of pages5
JournalBiochemical Society Transactions
Volume33
Issue number5
DOIs
Publication statusPublished - 1 Nov 2005

Keywords

  • animals
  • body weight
  • diet
  • reducing diet
  • animal disease models
  • energy metabolism
  • hypothalamus
  • neuropeptides
  • obesity
  • rats
  • Sprague-Dawley rats
  • agouti-related peptide
  • brain-derived neurotrophic factor (BDNF)
  • energy balance system
  • Ensure
  • neuropeptide Y

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