Dietary factors and biomarkers of systemic inflammation in older people

the Lothian Birth Cohort 1936

Janie Corley, Janet A M Kyle, John M Starr, Geraldine McNeill, Ian J Deary

Research output: Contribution to journalArticle

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Abstract

Epidemiological studies have reported inverse associations between various single healthy diet indices and lower levels of systemic inflammation, but rarely are they examined in the same sample. The aim of the present study was to investigate the potential relationships between biomarkers of systemic inflammation (C-reactive protein (CRP) and fibrinogen) and overall foods (dietary patterns), single foods (fruits and vegetables), and specific nutritive (antioxidants) and non-nutritive (flavonoids) food components in the same narrow-age cohort of older adults. The dietary intake of 792 participants aged 70 years from the Lothian Birth Cohort 1936 was assessed using a 168-item FFQ. Models were adjusted for age, sex, childhood cognitive ability, lifestyle factors and history of disease. Using logistic regression analyses, CRP (normal v. elevated) was favourably associated (at P< 0·05) with the 'health-aware' (low-fat) dietary pattern (unstandardised β = (0·200, OR 0·82, 95 % CI 0·68, 0·99) and fruit intake (unstandardised β = (0·100, OR 0·91, 95 % CI 0·82, 0·99), including flavonoid-rich apples (unstandardised β = (0·456, OR 0·63, 95 % CI 0·439, 0·946). Using linear regression analyses, fibrinogen (continuous) was inversely associated (at P< 0·05) with the Mediterranean dietary pattern (standardised β = (0·100), fruit intake (standardised β = (0·083), and combined fruit and vegetable intake (standardised β = (0·084). We observed no association between food components (antioxidant nutrients or specific flavonoid subclasses) and inflammatory markers. In the present cross-sectional study, nutrient-dense dietary patterns were associated with lower levels of systemic inflammation in older people. The results are consistent with dietary guidelines that promote a balanced diet based on a variety of plant-based foods.

Original languageEnglish
Pages (from-to)1088-1098
Number of pages11
JournalBritish Journal of Nutrition
Volume114
Issue number7
Early online date7 Sep 2015
DOIs
Publication statusPublished - Oct 2015

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Biomarkers
Parturition
Inflammation
Food
Fruit
Flavonoids
Vegetables
C-Reactive Protein
Fibrinogen
Antioxidants
Regression Analysis
Nutrition Policy
Edible Plants
Aptitude
Dietary Fats
Malus
Life Style
Epidemiologic Studies
Linear Models
Cross-Sectional Studies

Keywords

  • dietary patterns
  • inflamation
  • FFQ
  • cognitive ability

Cite this

Dietary factors and biomarkers of systemic inflammation in older people : the Lothian Birth Cohort 1936. / Corley, Janie; Kyle, Janet A M; Starr, John M; McNeill, Geraldine; Deary, Ian J.

In: British Journal of Nutrition, Vol. 114, No. 7, 10.2015, p. 1088-1098.

Research output: Contribution to journalArticle

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