Dietary influences on bone mass and bone metabolism: further evidence of a positive link between fruit and vegetable consumption and bone health?

S A New, S P Robins, M K Campbell, J C Martin, M J Garton, C Bolton-Smith, D A Grubb, S J Lee, D M Reid

Research output: Contribution to journalArticle

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Abstract

Background: The role of nutritional influences on bone health remains largely undefined because most studies have focused attention on calcium intake.

Objective: We reported previously that intakes of nutrients found in abundance in fruit and vegetables are positively associated with bone health. We examined this finding further by considering axial and peripheral bone mass and markers of bone metabolism.

Design: This was a cross-sectional study of 62 healthy women aged 45-55 y. Bone mineral density (BMD) was measured by dual-energy X-ray absorptiometry at the lumbar spine and femoral neck and by peripheral quantitative computed tomography at the ultradistal radial total, trabecular, and cortical sites. Bone resorption was calculated by measuring urinary excretion of pyridinoline and deoxypyridinoline and bone formation by measuring serum osteocalcin. Nutrient intakes were assessed by using a validated food-frequency questionnaire; other lifestyle factors were assessed by additional questions.

Results: After present energy intake was controlled far, higher intakes of magnesium, potassium, and alcohol were associated with higher total bone mass by Pearson correlation (P < 0.05 to P < 0.005). Femoral neck BMD was higher in women who had consumed high amounts of fruit in their childhood than in women who had consumed medium or low amounts (P < 0.01). In a regression analysis with age, weight, height, menstrual status, and dietary intake entered into the model, magnesium intake accounted for 12.3% of the variation in pyridinoline excretion and 12% of the variation in deoxypyridinoline excretion. Alcohol and potassium intakes accounted for 18.1% of the variation in total forearm bone mass.

Conclusion: The BMD results confirm our previous work (but at peripheral bone mass sites), and our findings associating bone resorption with dietary factors provide further evidence of a positive link between fruit and vegetable consumption and bone health.

Original languageEnglish
Pages (from-to)142-151
Number of pages10
JournalThe American Journal of Clinical Nutrition
Volume71
Publication statusPublished - 2000

Keywords

  • bone mass
  • bone turnover
  • pyridinium crosslinks
  • energy-adjusted nutrient intakes
  • potassium
  • magnesium
  • vitamin C
  • beta-carotene
  • fruit
  • vegetables
  • acid-base balance
  • women
  • FOOD-FREQUENCY QUESTIONNAIRE
  • URINARY CALCIUM EXCRETION
  • PYRIDINIUM CROSS-LINKS
  • MINERAL DENSITY
  • REGIONAL OSTEOPOROSIS
  • POTASSIUM BICARBONATE
  • POSTMENOPAUSAL WOMEN
  • ALCOHOL-CONSUMPTION
  • PREMENOPAUSAL WOMEN
  • RECRUITMENT METHODS

Cite this

Dietary influences on bone mass and bone metabolism: further evidence of a positive link between fruit and vegetable consumption and bone health? / New, S A ; Robins, S P ; Campbell, M K ; Martin, J C ; Garton, M J ; Bolton-Smith, C ; Grubb, D A ; Lee, S J ; Reid, D M .

In: The American Journal of Clinical Nutrition, Vol. 71, 2000, p. 142-151.

Research output: Contribution to journalArticle

New, S A ; Robins, S P ; Campbell, M K ; Martin, J C ; Garton, M J ; Bolton-Smith, C ; Grubb, D A ; Lee, S J ; Reid, D M . / Dietary influences on bone mass and bone metabolism: further evidence of a positive link between fruit and vegetable consumption and bone health?. In: The American Journal of Clinical Nutrition. 2000 ; Vol. 71. pp. 142-151.
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T1 - Dietary influences on bone mass and bone metabolism: further evidence of a positive link between fruit and vegetable consumption and bone health?

AU - New, S A

AU - Robins, S P

AU - Campbell, M K

AU - Martin, J C

AU - Garton, M J

AU - Bolton-Smith, C

AU - Grubb, D A

AU - Lee, S J

AU - Reid, D M

PY - 2000

Y1 - 2000

N2 - Background: The role of nutritional influences on bone health remains largely undefined because most studies have focused attention on calcium intake.Objective: We reported previously that intakes of nutrients found in abundance in fruit and vegetables are positively associated with bone health. We examined this finding further by considering axial and peripheral bone mass and markers of bone metabolism.Design: This was a cross-sectional study of 62 healthy women aged 45-55 y. Bone mineral density (BMD) was measured by dual-energy X-ray absorptiometry at the lumbar spine and femoral neck and by peripheral quantitative computed tomography at the ultradistal radial total, trabecular, and cortical sites. Bone resorption was calculated by measuring urinary excretion of pyridinoline and deoxypyridinoline and bone formation by measuring serum osteocalcin. Nutrient intakes were assessed by using a validated food-frequency questionnaire; other lifestyle factors were assessed by additional questions.Results: After present energy intake was controlled far, higher intakes of magnesium, potassium, and alcohol were associated with higher total bone mass by Pearson correlation (P < 0.05 to P < 0.005). Femoral neck BMD was higher in women who had consumed high amounts of fruit in their childhood than in women who had consumed medium or low amounts (P < 0.01). In a regression analysis with age, weight, height, menstrual status, and dietary intake entered into the model, magnesium intake accounted for 12.3% of the variation in pyridinoline excretion and 12% of the variation in deoxypyridinoline excretion. Alcohol and potassium intakes accounted for 18.1% of the variation in total forearm bone mass.Conclusion: The BMD results confirm our previous work (but at peripheral bone mass sites), and our findings associating bone resorption with dietary factors provide further evidence of a positive link between fruit and vegetable consumption and bone health.

AB - Background: The role of nutritional influences on bone health remains largely undefined because most studies have focused attention on calcium intake.Objective: We reported previously that intakes of nutrients found in abundance in fruit and vegetables are positively associated with bone health. We examined this finding further by considering axial and peripheral bone mass and markers of bone metabolism.Design: This was a cross-sectional study of 62 healthy women aged 45-55 y. Bone mineral density (BMD) was measured by dual-energy X-ray absorptiometry at the lumbar spine and femoral neck and by peripheral quantitative computed tomography at the ultradistal radial total, trabecular, and cortical sites. Bone resorption was calculated by measuring urinary excretion of pyridinoline and deoxypyridinoline and bone formation by measuring serum osteocalcin. Nutrient intakes were assessed by using a validated food-frequency questionnaire; other lifestyle factors were assessed by additional questions.Results: After present energy intake was controlled far, higher intakes of magnesium, potassium, and alcohol were associated with higher total bone mass by Pearson correlation (P < 0.05 to P < 0.005). Femoral neck BMD was higher in women who had consumed high amounts of fruit in their childhood than in women who had consumed medium or low amounts (P < 0.01). In a regression analysis with age, weight, height, menstrual status, and dietary intake entered into the model, magnesium intake accounted for 12.3% of the variation in pyridinoline excretion and 12% of the variation in deoxypyridinoline excretion. Alcohol and potassium intakes accounted for 18.1% of the variation in total forearm bone mass.Conclusion: The BMD results confirm our previous work (but at peripheral bone mass sites), and our findings associating bone resorption with dietary factors provide further evidence of a positive link between fruit and vegetable consumption and bone health.

KW - bone mass

KW - bone turnover

KW - pyridinium crosslinks

KW - energy-adjusted nutrient intakes

KW - potassium

KW - magnesium

KW - vitamin C

KW - beta-carotene

KW - fruit

KW - vegetables

KW - acid-base balance

KW - women

KW - FOOD-FREQUENCY QUESTIONNAIRE

KW - URINARY CALCIUM EXCRETION

KW - PYRIDINIUM CROSS-LINKS

KW - MINERAL DENSITY

KW - REGIONAL OSTEOPOROSIS

KW - POTASSIUM BICARBONATE

KW - POSTMENOPAUSAL WOMEN

KW - ALCOHOL-CONSUMPTION

KW - PREMENOPAUSAL WOMEN

KW - RECRUITMENT METHODS

M3 - Article

VL - 71

SP - 142

EP - 151

JO - The American Journal of Clinical Nutrition

JF - The American Journal of Clinical Nutrition

SN - 0002-9165

ER -