Dietary supplementation with conjugated linoleic acid plus n-3 polyunsatturated fatty acid increases food intake and brown adipose tissue in rats

Alan A Sneddon, D Vernon Rayner, Sharon E Mitchell, Shabina Bashir, Jung-Heun Ha, Klaus W Wahle, Amanda C Morris, Lynda M Williams

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The effect of supplementation with 1% conjugated linoleic acid and 1% n-3 long chain polyunsaturated fatty acids (CLA/n-3) was assessed in rats. Food intake increased with no difference in body weights. White adipose tissue weights were reduced whereas brown adipose tissue and uncoupling protein-1 expression were increased. Plasma adiponectin, triglyceride and cholesterol levels were reduced while leptin, ghrelin and liver weight and lipid content were unchanged. Hypothalamic gene expression measurements revealed increased expression of orexigenic and decreased expression of anorexigenic signals. Thus, CLA/n-3 increases food intake without affecting body weight potentially through increasing BAT size and up-regulating UCP-1 in rats.
Original languageEnglish
Pages (from-to)178-196
Number of pages19
Issue number2
Publication statusPublished - 26 Nov 2009



  • conjugated linoleic acid
  • n-3 long chain polyunsaturated fatty acid
  • white adipose tissue
  • brown adipose tissue
  • hypothalamus
  • brain

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