Dietary supplementation with conjugated linoleic acid plus n-3 polyunsatturated fatty acid increases food intake and brown adipose tissue in rats

Alan A Sneddon, D Vernon Rayner, Sharon E Mitchell, Shabina Bashir, Jung-Heun Ha, Klaus W Wahle, Amanda C Morris, Lynda M Williams

Research output: Contribution to journalArticle

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Abstract

The effect of supplementation with 1% conjugated linoleic acid and 1% n-3 long chain polyunsaturated fatty acids (CLA/n-3) was assessed in rats. Food intake increased with no difference in body weights. White adipose tissue weights were reduced whereas brown adipose tissue and uncoupling protein-1 expression were increased. Plasma adiponectin, triglyceride and cholesterol levels were reduced while leptin, ghrelin and liver weight and lipid content were unchanged. Hypothalamic gene expression measurements revealed increased expression of orexigenic and decreased expression of anorexigenic signals. Thus, CLA/n-3 increases food intake without affecting body weight potentially through increasing BAT size and up-regulating UCP-1 in rats.
Original languageEnglish
Pages (from-to)178-196
Number of pages19
JournalNutrients
Volume1
Issue number2
DOIs
Publication statusPublished - 26 Nov 2009

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Conjugated Linoleic Acids
Brown Adipose Tissue
brown adipose tissue
Omega-3 Fatty Acids
conjugated linoleic acid
Dietary Supplements
omega-3 fatty acids
dietary supplements
food intake
Eating
Body Weight
Weights and Measures
ghrelin
White Adipose Tissue
white adipose tissue
adiponectin
Ghrelin
long chain polyunsaturated fatty acids
body weight
Adiponectin

Keywords

  • conjugated linoleic acid
  • n-3 long chain polyunsaturated fatty acid
  • white adipose tissue
  • brown adipose tissue
  • hypothalamus
  • brain

Cite this

Dietary supplementation with conjugated linoleic acid plus n-3 polyunsatturated fatty acid increases food intake and brown adipose tissue in rats. / Sneddon, Alan A; Rayner, D Vernon; Mitchell, Sharon E; Bashir, Shabina; Ha, Jung-Heun; Wahle, Klaus W; Morris, Amanda C; Williams, Lynda M.

In: Nutrients, Vol. 1, No. 2, 26.11.2009, p. 178-196.

Research output: Contribution to journalArticle

Sneddon, Alan A ; Rayner, D Vernon ; Mitchell, Sharon E ; Bashir, Shabina ; Ha, Jung-Heun ; Wahle, Klaus W ; Morris, Amanda C ; Williams, Lynda M. / Dietary supplementation with conjugated linoleic acid plus n-3 polyunsatturated fatty acid increases food intake and brown adipose tissue in rats. In: Nutrients. 2009 ; Vol. 1, No. 2. pp. 178-196.
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