Dietary supplementation with L-arginine in patients with breast cancer (> 4 cm) receiving multimodality treatment: Report of a feasibility study

J. Brittenden, S. D. Heys*, I. Miller, T. K. Sarkar, A. W. Hutcheon, G. Needham, F. Gilbert, M. McKean, A. K. Ah-See, O. Eremin

*Corresponding author for this work

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24 Citations (Scopus)

Abstract

L-Arginine has been shown, in human breast cancers, to increase protein synthesis and the number of cells in the growth phase of the cell cycle. L-Arginine, therefore, may potentiate the response of breast cancers to cell cycle-specific cytotoxic agents. This phase II pilot study assessed the clinical, radiological and pathological responses in 44 patients with breast cancers > 4 cm in diameter (46 tumours: T2, n = 6; T3, n = 22; T4, n = 19), who received oral L-arginine 30 g day-1 for 3 days prior to each cycle of CHOP chemotherapy, followed after 4-6 cycles by radiotherapy. Following this treatment, 95% of patients had a clinical response: Complete response in 30% and partial response in 65%. Imaging, ultrasound and mammography revealed response rates of 91% and 76% respectively. Surgery was performed in 43 patients. Histological examination revealed that in 18% of cases there was no residual evidence of tumour. Furthermore, if residual tumour was identified, the degree of destruction was graded as ‘severe’ in 36% and ‘moderate’ in 30% of cases. Further studies are now required to evaluate the potential beneficial use of nutritional pharmacology in combination with existing treatment regimens.

Original languageEnglish
Pages (from-to)918-921
Number of pages4
JournalBritish Journal of Cancer
Volume69
Issue number5
DOIs
Publication statusPublished - 1 May 1994

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Brittenden, J., Heys, S. D., Miller, I., Sarkar, T. K., Hutcheon, A. W., Needham, G., Gilbert, F., McKean, M., Ah-See, A. K., & Eremin, O. (1994). Dietary supplementation with L-arginine in patients with breast cancer (> 4 cm) receiving multimodality treatment: Report of a feasibility study. British Journal of Cancer, 69(5), 918-921. https://doi.org/10.1038/bjc.1994.177