Dietary supplementation with L-arginine: Modulation of tumour-infiltrating lymphocytes in patients with colorectal cancer

S. D. Heys*, A. Segar, S. Payne, D. M. Bruce, N. Kernohan, O. Eremin

*Corresponding author for this work

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Background: Dietary supplementation with L-arginine enhances natural cytotoxicity in peripheral blood lymphocytes but its effect on infiltrating lymphoreticular cells within a tumour microenvironment is unknown. The effects of dietary supplementation with L-arginine on tumour-infiltrating lymphocytes (TILs) in patients with colorectal cancer were evaluated. Methods: Eighteen patients received either a standard hospital diet (controls) or a standard diet supplemented with 30 g per day of L-arginine for 3 days before surgery. Tumour biopsies were taken at surgery and lymphocyte subsets (CD antigens) and macrophages examined immunohistochemically. Results: Tumours from patients receiving L-arginine contained increased numbers of specific cell subsets within the tumour which expressed CD16 (P = 0.004) and CD56 (P = 0.001) surface markers, when compared with tumours from control patients. There were no differences in the total number of T and B cells, T helper and T suppressor cells. Conclusion: Dietary supplementation with L-arginine significantly alters the spectrum of TILs in human colorectal cancers in vivo. These findings have important implications for new strategies in anticancer treatment.

Original languageEnglish
Pages (from-to)238-241
Number of pages4
JournalBritish Journal of Surgery
Volume84
Issue number2
Publication statusPublished - 21 Feb 1997

ASJC Scopus subject areas

  • Surgery

Fingerprint Dive into the research topics of 'Dietary supplementation with L-arginine: Modulation of tumour-infiltrating lymphocytes in patients with colorectal cancer'. Together they form a unique fingerprint.

  • Cite this

    Heys, S. D., Segar, A., Payne, S., Bruce, D. M., Kernohan, N., & Eremin, O. (1997). Dietary supplementation with L-arginine: Modulation of tumour-infiltrating lymphocytes in patients with colorectal cancer. British Journal of Surgery, 84(2), 238-241.