Diets containing sea cucumber (Isostichopus badionotus) meals are hypocholesterolemic in young rats

Leticia Olivera-Castillo, Alberto Davalos, George Grant, Nina Valadez-Gonzalez, Jorge Montero, Hirian Alonso Moshe Barrera-Perez, Yasser Chim-Chi, Miguel Angel Olvera-Novoa, Víctor Ceja-Moreno, Pablo Acereto-Escoffie, Jorge Rubio-Piña, Rossanna Rodriguez-Canul

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Abstract

Sea cucumber is widely consumed as a putative functional food. It contains many biologically-active substances, but only limited research on its properties in vivo has been done. The effects of different meals containing Isostichopus badionotus, a sea cucumber from southeast Mexico, on growth performance and body lipid profile in young rats were analyzed. Sea cucumber body wall was either lyophilized, cooked (100 °C, 1 h in water) and lyophilized, or oven-dried (70 °C for 12 h). It was then ground and incorporated into cholesterol-containing diets. I. badionotus meals supported growth and improved lipid profile in rats. In particular, serum cholesterol, low density lipoproteins, triglycerides concentration and atherogenic index values were greatly reduced by some I. badionotus containing diets. Liver total lipids, triglycerides and cholesterol were also reduced. Cooking or heat-treatment of the meals lowered but did not abolish their hypolipidemic potency. Gene expression analysis of several key genes involved in cholesterol and lipid metabolism in liver showed that diets containing I. badionotus repressed the induction of key genes associated with dyslipidemia exerted by cholesterol supplementation. Consumption of I. badionotus from the Yucatan Peninsula is beneficial for dyslipidemia, although biological effect is clearly dependent on preparation method.
Original languageEnglish
Article numbere79446
Number of pages14
JournalPloS ONE
Volume8
Issue number11
DOIs
Publication statusPublished - 19 Nov 2013

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Sea Cucumbers
Holothuroidea
Nutrition
Meals
Rats
Cholesterol
cholesterol
hyperlipidemia
Diet
rats
triacylglycerols
Lipids
diet
Liver
Dyslipidemias
cholesterol metabolism
liver
Genes
lipids
low density lipoprotein cholesterol

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Olivera-Castillo, L., Davalos, A., Grant, G., Valadez-Gonzalez, N., Montero, J., Barrera-Perez, H. A. M., ... Rodriguez-Canul, R. (2013). Diets containing sea cucumber (Isostichopus badionotus) meals are hypocholesterolemic in young rats. PloS ONE, 8(11), [e79446]. https://doi.org/10.1371/journal.pone.0079446

Diets containing sea cucumber (Isostichopus badionotus) meals are hypocholesterolemic in young rats. / Olivera-Castillo, Leticia; Davalos, Alberto; Grant, George; Valadez-Gonzalez, Nina; Montero, Jorge; Barrera-Perez, Hirian Alonso Moshe; Chim-Chi, Yasser; Olvera-Novoa, Miguel Angel; Ceja-Moreno, Víctor; Acereto-Escoffie, Pablo; Rubio-Piña, Jorge; Rodriguez-Canul, Rossanna.

In: PloS ONE, Vol. 8, No. 11, e79446, 19.11.2013.

Research output: Contribution to journalArticle

Olivera-Castillo, L, Davalos, A, Grant, G, Valadez-Gonzalez, N, Montero, J, Barrera-Perez, HAM, Chim-Chi, Y, Olvera-Novoa, MA, Ceja-Moreno, V, Acereto-Escoffie, P, Rubio-Piña, J & Rodriguez-Canul, R 2013, 'Diets containing sea cucumber (Isostichopus badionotus) meals are hypocholesterolemic in young rats', PloS ONE, vol. 8, no. 11, e79446. https://doi.org/10.1371/journal.pone.0079446
Olivera-Castillo L, Davalos A, Grant G, Valadez-Gonzalez N, Montero J, Barrera-Perez HAM et al. Diets containing sea cucumber (Isostichopus badionotus) meals are hypocholesterolemic in young rats. PloS ONE. 2013 Nov 19;8(11). e79446. https://doi.org/10.1371/journal.pone.0079446
Olivera-Castillo, Leticia ; Davalos, Alberto ; Grant, George ; Valadez-Gonzalez, Nina ; Montero, Jorge ; Barrera-Perez, Hirian Alonso Moshe ; Chim-Chi, Yasser ; Olvera-Novoa, Miguel Angel ; Ceja-Moreno, Víctor ; Acereto-Escoffie, Pablo ; Rubio-Piña, Jorge ; Rodriguez-Canul, Rossanna. / Diets containing sea cucumber (Isostichopus badionotus) meals are hypocholesterolemic in young rats. In: PloS ONE. 2013 ; Vol. 8, No. 11.
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