Differences in Body Mass Index between Siblings Who Are Discordant for Exposure to Antenatal Maternal Smoking

Lorna Aucott; Sohinee Bhattacharya; Geraldine McNeill; Steve Turner

doi:10.1111/ppe.12386

Differences in Body Mass Index between Siblings Who Are Discordant for Exposure to Antenatal Maternal Smoking

Lorna Aucott, Sohinee Bhattacharya, Geraldine McNeill, Steve Turner

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

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Abstract

Background. Maternal smoking during pregnancy is associated with increased childhood body mass index (BMI) but the relationship may be due to confounding by maternal factors. This study tested the hypothesis that siblings born to mothers who begin to smoke between pregnancies will have higher BMI than older unexposed siblings.

Methods. Maternal details from the Aberdeen Maternity and Neonatal Databank were linked to the Study of Trends in Obesity in North East Scotland which holds offspring BMI at five years of age.Change in maternal smoking status between pregnancies was linked to offspring BMI and also to the difference in BMI between siblings.

Results. Maternal smoking status in successive pregnancies was linked to child BMI at age 5 years in 6,581 mother-child pairs of whom 718 included sibling pars. Children whose mothers had quit,started smoking or smoked in consecutive pregnancies had higher BMI compared to those not exposed to maternal smoking. Siblings born after onset of maternal smoking had higher mean BMI z score or (0.20 95% confidence interval CI [(0.03, 0.38])) compared to unexposed older siblings. Mean BMI z score was also higher by mean of 0.10 [(95% CI0.00, 0.19]) in younger sibling compared to older siblings born to mothers who smoked in both pregnancies. BMI z score was not significantly different between siblings whose mothers quit between pregnancies.

Conclusions. In utero exposure to maternal smoking during pregnancy may increase the likelihood of increased BMI in childhood.

Original language	English
Pages (from-to)	402-408
Number of pages	7
Journal	Paediatric and Perinatal Epidemiology
Volume	31
Issue number	5
Early online date	2 Aug 2017
DOIs	https://doi.org/10.1111/ppe.12386
Publication status	Published - Sep 2017

Keywords

child
obesity
pregnancy
smoking

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1111/ppe.12386Licence: Unspecified

Accepted Manuscript
This is the peer reviewed version of the following article:Aucott, L., Bhattacharya, S., McNeill, G. and Turner, S. (2017), Differences in Body Mass Index between Siblings Who Are Discordant for Exposure to Antenatal Maternal Smoking. Paediatr. Perinat. Epidemiol., 31: 402–408., which has been published in final form at DOI: 10.1111/ppe.12386. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving
Accepted author manuscript, 372 KBLicence: Unspecified

Aberdeen Maternity and Neonatal Databank
Bhattacharya, S. (Data Manager) & Wilde, K. (Supervisor), University of Aberdeen, 1986
http://www.abdn.ac.uk/iahs/research/obsgynae/amnd/overview.php and one more link, http://www.abdn.ac.uk/iahs/research/obsgynae/amnd/access.php (show fewer)
Dataset

Grampian Data Safe Haven (DaSH)
Katie Wilde (Manager)
Institute of Applied Health Sciences
Research Facilities: Facility

Cite this

@article{646faf723f0c41d58b990461adb6464a,

title = "Differences in Body Mass Index between Siblings Who Are Discordant for Exposure to Antenatal Maternal Smoking",

abstract = "Background. Maternal smoking during pregnancy is associated with increased childhood body mass index (BMI) but the relationship may be due to confounding by maternal factors. This study tested the hypothesis that siblings born to mothers who begin to smoke between pregnancies will have higher BMI than older unexposed siblings.Methods. Maternal details from the Aberdeen Maternity and Neonatal Databank were linked to the Study of Trends in Obesity in North East Scotland which holds offspring BMI at five years of age.Change in maternal smoking status between pregnancies was linked to offspring BMI and also to the difference in BMI between siblings.Results. Maternal smoking status in successive pregnancies was linked to child BMI at age 5 years in 6,581 mother-child pairs of whom 718 included sibling pars. Children whose mothers had quit,started smoking or smoked in consecutive pregnancies had higher BMI compared to those not exposed to maternal smoking. Siblings born after onset of maternal smoking had higher mean BMI z score or (0.20 95% confidence interval CI [(0.03, 0.38])) compared to unexposed older siblings. Mean BMI z score was also higher by mean of 0.10 [(95% CI0.00, 0.19]) in younger sibling compared to older siblings born to mothers who smoked in both pregnancies. BMI z score was not significantly different between siblings whose mothers quit between pregnancies.Conclusions. In utero exposure to maternal smoking during pregnancy may increase the likelihood of increased BMI in childhood.",

keywords = "child, obesity, pregnancy, smoking",

author = "Lorna Aucott and Sohinee Bhattacharya and Geraldine McNeill and Steve Turner",

note = "ACKNOWLEDGEMENTS The authors express their gratitude to the staff at the Grampian data safe haven for their assistance during this linkage study. This work was supported by FARR institute whose funding supported statistical time and the linkage ",

year = "2017",

month = sep,

doi = "10.1111/ppe.12386",

language = "English",

volume = "31",

pages = "402--408",

journal = "Paediatric and Perinatal Epidemiology",

issn = "0269-5022",

publisher = "Wiley-Blackwell",

number = "5",

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T1 - Differences in Body Mass Index between Siblings Who Are Discordant for Exposure to Antenatal Maternal Smoking

AU - Aucott, Lorna

AU - Bhattacharya, Sohinee

AU - McNeill, Geraldine

AU - Turner, Steve

N1 - ACKNOWLEDGEMENTS The authors express their gratitude to the staff at the Grampian data safe haven for their assistance during this linkage study. This work was supported by FARR institute whose funding supported statistical time and the linkage

PY - 2017/9

Y1 - 2017/9

N2 - Background. Maternal smoking during pregnancy is associated with increased childhood body mass index (BMI) but the relationship may be due to confounding by maternal factors. This study tested the hypothesis that siblings born to mothers who begin to smoke between pregnancies will have higher BMI than older unexposed siblings.Methods. Maternal details from the Aberdeen Maternity and Neonatal Databank were linked to the Study of Trends in Obesity in North East Scotland which holds offspring BMI at five years of age.Change in maternal smoking status between pregnancies was linked to offspring BMI and also to the difference in BMI between siblings.Results. Maternal smoking status in successive pregnancies was linked to child BMI at age 5 years in 6,581 mother-child pairs of whom 718 included sibling pars. Children whose mothers had quit,started smoking or smoked in consecutive pregnancies had higher BMI compared to those not exposed to maternal smoking. Siblings born after onset of maternal smoking had higher mean BMI z score or (0.20 95% confidence interval CI [(0.03, 0.38])) compared to unexposed older siblings. Mean BMI z score was also higher by mean of 0.10 [(95% CI0.00, 0.19]) in younger sibling compared to older siblings born to mothers who smoked in both pregnancies. BMI z score was not significantly different between siblings whose mothers quit between pregnancies.Conclusions. In utero exposure to maternal smoking during pregnancy may increase the likelihood of increased BMI in childhood.

AB - Background. Maternal smoking during pregnancy is associated with increased childhood body mass index (BMI) but the relationship may be due to confounding by maternal factors. This study tested the hypothesis that siblings born to mothers who begin to smoke between pregnancies will have higher BMI than older unexposed siblings.Methods. Maternal details from the Aberdeen Maternity and Neonatal Databank were linked to the Study of Trends in Obesity in North East Scotland which holds offspring BMI at five years of age.Change in maternal smoking status between pregnancies was linked to offspring BMI and also to the difference in BMI between siblings.Results. Maternal smoking status in successive pregnancies was linked to child BMI at age 5 years in 6,581 mother-child pairs of whom 718 included sibling pars. Children whose mothers had quit,started smoking or smoked in consecutive pregnancies had higher BMI compared to those not exposed to maternal smoking. Siblings born after onset of maternal smoking had higher mean BMI z score or (0.20 95% confidence interval CI [(0.03, 0.38])) compared to unexposed older siblings. Mean BMI z score was also higher by mean of 0.10 [(95% CI0.00, 0.19]) in younger sibling compared to older siblings born to mothers who smoked in both pregnancies. BMI z score was not significantly different between siblings whose mothers quit between pregnancies.Conclusions. In utero exposure to maternal smoking during pregnancy may increase the likelihood of increased BMI in childhood.

KW - child

KW - obesity

KW - pregnancy

KW - smoking

U2 - 10.1111/ppe.12386

DO - 10.1111/ppe.12386

M3 - Article

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JO - Paediatric and Perinatal Epidemiology

JF - Paediatric and Perinatal Epidemiology

SN - 0269-5022

IS - 5

ER -

Differences in Body Mass Index between Siblings Who Are Discordant for Exposure to Antenatal Maternal Smoking

Abstract

Keywords

UN SDGs

Access to Document

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Datasets

Aberdeen Maternity and Neonatal Databank

Equipment

Grampian Data Safe Haven (DaSH)

Cite this