Differences in Body Mass Index between Siblings Who Are Discordant for Exposure to Antenatal Maternal Smoking

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Abstract

Background. Maternal smoking during pregnancy is associated with increased childhood body mass index (BMI) but the relationship may be due to confounding by maternal factors. This study tested the hypothesis that siblings born to mothers who begin to smoke between pregnancies will have higher BMI than older unexposed siblings.

Methods. Maternal details from the Aberdeen Maternity and Neonatal Databank were linked to the Study of Trends in Obesity in North East Scotland which holds offspring BMI at five years of age.Change in maternal smoking status between pregnancies was linked to offspring BMI and also to the difference in BMI between siblings.

Results. Maternal smoking status in successive pregnancies was linked to child BMI at age 5 years in 6,581 mother-child pairs of whom 718 included sibling pars. Children whose mothers had quit,started smoking or smoked in consecutive pregnancies had higher BMI compared to those not exposed to maternal smoking. Siblings born after onset of maternal smoking had higher mean BMI z score or (0.20 95% confidence interval CI [(0.03, 0.38])) compared to unexposed older siblings. Mean BMI z score was also higher by mean of 0.10 [(95% CI0.00, 0.19]) in younger sibling compared to older siblings born to mothers who smoked in both pregnancies. BMI z score was not significantly different between siblings whose mothers quit between pregnancies.

Conclusions. In utero exposure to maternal smoking during pregnancy may increase the likelihood of increased BMI in childhood.
Original languageEnglish
Pages (from-to)402-408
Number of pages7
JournalPaediatric and Perinatal Epidemiology
Volume31
Issue number5
Early online date2 Aug 2017
DOIs
Publication statusPublished - Sep 2017

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Siblings
Body Mass Index
Smoking
Mothers
Pregnancy
Maternal Exposure
Scotland
Smoke
Obesity
Databases
Confidence Intervals

Keywords

  • child
  • obesity
  • pregnancy
  • smoking

Cite this

@article{646faf723f0c41d58b990461adb6464a,
title = "Differences in Body Mass Index between Siblings Who Are Discordant for Exposure to Antenatal Maternal Smoking",
abstract = "Background. Maternal smoking during pregnancy is associated with increased childhood body mass index (BMI) but the relationship may be due to confounding by maternal factors. This study tested the hypothesis that siblings born to mothers who begin to smoke between pregnancies will have higher BMI than older unexposed siblings.Methods. Maternal details from the Aberdeen Maternity and Neonatal Databank were linked to the Study of Trends in Obesity in North East Scotland which holds offspring BMI at five years of age.Change in maternal smoking status between pregnancies was linked to offspring BMI and also to the difference in BMI between siblings.Results. Maternal smoking status in successive pregnancies was linked to child BMI at age 5 years in 6,581 mother-child pairs of whom 718 included sibling pars. Children whose mothers had quit,started smoking or smoked in consecutive pregnancies had higher BMI compared to those not exposed to maternal smoking. Siblings born after onset of maternal smoking had higher mean BMI z score or (0.20 95{\%} confidence interval CI [(0.03, 0.38])) compared to unexposed older siblings. Mean BMI z score was also higher by mean of 0.10 [(95{\%} CI0.00, 0.19]) in younger sibling compared to older siblings born to mothers who smoked in both pregnancies. BMI z score was not significantly different between siblings whose mothers quit between pregnancies.Conclusions. In utero exposure to maternal smoking during pregnancy may increase the likelihood of increased BMI in childhood.",
keywords = "child, obesity, pregnancy, smoking",
author = "Lorna Aucott and Sohinee Bhattacharya and Geraldine McNeill and Steve Turner",
note = "ACKNOWLEDGEMENTS The authors express their gratitude to the staff at the Grampian data safe haven for their assistance during this linkage study. This work was supported by FARR institute whose funding supported statistical time and the linkage",
year = "2017",
month = "9",
doi = "10.1111/ppe.12386",
language = "English",
volume = "31",
pages = "402--408",
journal = "Paediatric and Perinatal Epidemiology",
issn = "0269-5022",
publisher = "Wiley-Blackwell",
number = "5",

}

TY - JOUR

T1 - Differences in Body Mass Index between Siblings Who Are Discordant for Exposure to Antenatal Maternal Smoking

AU - Aucott, Lorna

AU - Bhattacharya, Sohinee

AU - McNeill, Geraldine

AU - Turner, Steve

N1 - ACKNOWLEDGEMENTS The authors express their gratitude to the staff at the Grampian data safe haven for their assistance during this linkage study. This work was supported by FARR institute whose funding supported statistical time and the linkage

PY - 2017/9

Y1 - 2017/9

N2 - Background. Maternal smoking during pregnancy is associated with increased childhood body mass index (BMI) but the relationship may be due to confounding by maternal factors. This study tested the hypothesis that siblings born to mothers who begin to smoke between pregnancies will have higher BMI than older unexposed siblings.Methods. Maternal details from the Aberdeen Maternity and Neonatal Databank were linked to the Study of Trends in Obesity in North East Scotland which holds offspring BMI at five years of age.Change in maternal smoking status between pregnancies was linked to offspring BMI and also to the difference in BMI between siblings.Results. Maternal smoking status in successive pregnancies was linked to child BMI at age 5 years in 6,581 mother-child pairs of whom 718 included sibling pars. Children whose mothers had quit,started smoking or smoked in consecutive pregnancies had higher BMI compared to those not exposed to maternal smoking. Siblings born after onset of maternal smoking had higher mean BMI z score or (0.20 95% confidence interval CI [(0.03, 0.38])) compared to unexposed older siblings. Mean BMI z score was also higher by mean of 0.10 [(95% CI0.00, 0.19]) in younger sibling compared to older siblings born to mothers who smoked in both pregnancies. BMI z score was not significantly different between siblings whose mothers quit between pregnancies.Conclusions. In utero exposure to maternal smoking during pregnancy may increase the likelihood of increased BMI in childhood.

AB - Background. Maternal smoking during pregnancy is associated with increased childhood body mass index (BMI) but the relationship may be due to confounding by maternal factors. This study tested the hypothesis that siblings born to mothers who begin to smoke between pregnancies will have higher BMI than older unexposed siblings.Methods. Maternal details from the Aberdeen Maternity and Neonatal Databank were linked to the Study of Trends in Obesity in North East Scotland which holds offspring BMI at five years of age.Change in maternal smoking status between pregnancies was linked to offspring BMI and also to the difference in BMI between siblings.Results. Maternal smoking status in successive pregnancies was linked to child BMI at age 5 years in 6,581 mother-child pairs of whom 718 included sibling pars. Children whose mothers had quit,started smoking or smoked in consecutive pregnancies had higher BMI compared to those not exposed to maternal smoking. Siblings born after onset of maternal smoking had higher mean BMI z score or (0.20 95% confidence interval CI [(0.03, 0.38])) compared to unexposed older siblings. Mean BMI z score was also higher by mean of 0.10 [(95% CI0.00, 0.19]) in younger sibling compared to older siblings born to mothers who smoked in both pregnancies. BMI z score was not significantly different between siblings whose mothers quit between pregnancies.Conclusions. In utero exposure to maternal smoking during pregnancy may increase the likelihood of increased BMI in childhood.

KW - child

KW - obesity

KW - pregnancy

KW - smoking

U2 - 10.1111/ppe.12386

DO - 10.1111/ppe.12386

M3 - Article

VL - 31

SP - 402

EP - 408

JO - Paediatric and Perinatal Epidemiology

JF - Paediatric and Perinatal Epidemiology

SN - 0269-5022

IS - 5

ER -