Differential effect of polyphenol-rich dark chocolate on biomarkers of glucose metabolism and cardiovascular risk factors in healthy, overweight and obese subjects

a randomized clinical trial

S Almoosawi, C Tsang, L M Ostertag, L Fyfe, E A S Al-Dujaili

    Research output: Contribution to journalArticle

    50 Citations (Scopus)

    Abstract

    The association between excess cortisol and various parameters of metabolic syndrome including hypertension, insulin resistance and dyslipidaemia is increasingly recognised. The present single-blind randomised placebo-controlled cross-over study compared the effect of polyphenol-rich dark chocolate (DC) on biomarkers of glucose metabolism, lipid profile, and blood pressure (BP) in females with BMI = 25 kg m(-2) (n = 21) and females with BMI <25 kg m(-2) (n = 21). Volunteers consumed 20 g of DC containing 500 mg polyphenols or a placebo DC with negligible polyphenol-content daily for 4 weeks, separated by a 2-week washout period. Systolic BP and diastolic BP decreased after 4 weeks of polyphenol-rich DC. Placebo raised fasting insulin, homeostasis model assessment of insulin resistance (HOMA-IR) and salivary cortisol, an effect that was significantly different from polyphenol-rich DC which had a negligible effect on fasting insulin, HOMA-IR and salivary cortisol. Females with BMI = 25 kg m(-2) responded less favourably to placebo than lean females and consequently had higher fasting insulin and HOMA-IR, in addition to a lower quantitative sensitivity check index (QUICKI) after ingestion of placebo compared to polyphenol-rich DC. No significant changes in lipid profile were observed. This study provides evidence for the metabolic benefits of consuming polyphenol-rich dark chocolate while demonstrating the possibility of adverse effects occurring with polyphenol-poor chocolate placebo.
    Original languageEnglish
    Pages (from-to)1035-1043
    Number of pages9
    JournalFood & Function
    Volume10
    Early online date3 Jul 2012
    DOIs
    Publication statusPublished - 2012

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    randomized clinical trials
    chocolate
    Polyphenols
    biomarkers
    polyphenols
    risk factors
    Randomized Controlled Trials
    Biomarkers
    placebos
    Glucose
    glucose
    metabolism
    Placebos
    insulin resistance
    Insulin Resistance
    Blood Pressure
    cortisol
    fasting
    Hydrocortisone
    Fasting

    Cite this

    Differential effect of polyphenol-rich dark chocolate on biomarkers of glucose metabolism and cardiovascular risk factors in healthy, overweight and obese subjects : a randomized clinical trial. / Almoosawi, S; Tsang, C; Ostertag, L M; Fyfe, L; Al-Dujaili, E A S.

    In: Food & Function, Vol. 10, 2012, p. 1035-1043.

    Research output: Contribution to journalArticle

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