Differential effects of inhaled corticosteroids in smokers/ex-smokers and nonsmokers with asthma

Nicolas Roche; Dirkje S Postma; Gene Colice; Anne Burden; Theresa W Guilbert; Elliot Israel; Richard J Martin; Willem M C van Aalderen; Jonathan Grigg; Elizabeth V Hillyer; Julie von Ziegenweidt; David B Price

doi:10.1164/rccm.201411-2116LE

Differential effects of inhaled corticosteroids in smokers/ex-smokers and nonsmokers with asthma

Nicolas Roche, Dirkje S Postma, Gene Colice, Anne Burden, Theresa W Guilbert, Elliot Israel, Richard J Martin, Willem M C van Aalderen, Jonathan Grigg, Elizabeth V Hillyer, Julie von Ziegenweidt, David B Price

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

Abstract

Cigarette smoking decreases corticosteroid sensitivity in patients with asthma and worsens their symptoms and exacerbation frequency. Inhaled corticosteroids (ICS) are the cornerstone of asthma treatment. However, the optimal therapies for smokers with asthma are not well deﬁned because smokers (and ex-smokers with a >10 pack-year history) are usually excluded from clinical trials. Exposure to even low levels of cigarette smoke is known to induce small airway inﬂammation (5, 6), which is associated with worse asthma control. Therefore, ICS deposition in small airways, which increases with small- versus standard-size–particle ICS, might be an important determinant of ICS effectiveness in smokers with asthma.

Original language	English
Pages (from-to)	960-964
Number of pages	5
Journal	American Journal of Respiratory and Critical Care Medicine
Volume	191
Issue number	8
DOIs	https://doi.org/10.1164/rccm.201411-2116LE
Publication status	Published - 15 Apr 2015

Keywords

Inhaled Corticosteroids
Smokers
Ex-Smokers
Non Smokers
Differential Effects

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Roche, N., Postma, D. S., Colice, G., Burden, A., Guilbert, T. W., Israel, E., Martin, R. J., van Aalderen, W. M. C., Grigg, J., Hillyer, E. V., von Ziegenweidt, J., & Price, D. B. (2015). Differential effects of inhaled corticosteroids in smokers/ex-smokers and nonsmokers with asthma. American Journal of Respiratory and Critical Care Medicine, 191(8), 960-964. https://doi.org/10.1164/rccm.201411-2116LE

Roche, N, Postma, DS, Colice, G, Burden, A, Guilbert, TW, Israel, E, Martin, RJ, van Aalderen, WMC, Grigg, J, Hillyer, EV, von Ziegenweidt, J & Price, DB 2015, 'Differential effects of inhaled corticosteroids in smokers/ex-smokers and nonsmokers with asthma', American Journal of Respiratory and Critical Care Medicine, vol. 191, no. 8, pp. 960-964. https://doi.org/10.1164/rccm.201411-2116LE

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title = "Differential effects of inhaled corticosteroids in smokers/ex-smokers and nonsmokers with asthma",

abstract = "Cigarette smoking decreases corticosteroid sensitivity in patients with asthma and worsens their symptoms and exacerbation frequency. Inhaled corticosteroids (ICS) are the cornerstone of asthma treatment. However, the optimal therapies for smokers with asthma are not well deﬁned because smokers (and ex-smokers with a >10 pack-year history) are usually excluded from clinical trials. Exposure to even low levels of cigarette smoke is known to induce small airway inﬂammation (5, 6), which is associated with worse asthma control. Therefore, ICS deposition in small airways, which increases with small- versus standard-size–particle ICS, might be an important determinant of ICS effectiveness in smokers with asthma.",

keywords = "Inhaled Corticosteroids, Smokers, Ex-Smokers, Non Smokers, Differential Effects",

author = "Nicolas Roche and Postma, {Dirkje S} and Gene Colice and Anne Burden and Guilbert, {Theresa W} and Elliot Israel and Martin, {Richard J} and {van Aalderen}, {Willem M C} and Jonathan Grigg and Hillyer, {Elizabeth V} and {von Ziegenweidt}, Julie and Price, {David B}",

note = "Supported by an unrestricted grant from Teva Pharmaceuticals Limited of Petach Tikva, Israel (for data acquisition and analysis). Access to data from the Optimum Patient Care Research Database was cofunded by Research in Real-Life Ltd. ",

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AU - Postma, Dirkje S

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AU - Israel, Elliot

AU - Martin, Richard J

AU - van Aalderen, Willem M C

AU - Grigg, Jonathan

AU - Hillyer, Elizabeth V

AU - von Ziegenweidt, Julie

AU - Price, David B

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N2 - Cigarette smoking decreases corticosteroid sensitivity in patients with asthma and worsens their symptoms and exacerbation frequency. Inhaled corticosteroids (ICS) are the cornerstone of asthma treatment. However, the optimal therapies for smokers with asthma are not well deﬁned because smokers (and ex-smokers with a >10 pack-year history) are usually excluded from clinical trials. Exposure to even low levels of cigarette smoke is known to induce small airway inﬂammation (5, 6), which is associated with worse asthma control. Therefore, ICS deposition in small airways, which increases with small- versus standard-size–particle ICS, might be an important determinant of ICS effectiveness in smokers with asthma.

AB - Cigarette smoking decreases corticosteroid sensitivity in patients with asthma and worsens their symptoms and exacerbation frequency. Inhaled corticosteroids (ICS) are the cornerstone of asthma treatment. However, the optimal therapies for smokers with asthma are not well deﬁned because smokers (and ex-smokers with a >10 pack-year history) are usually excluded from clinical trials. Exposure to even low levels of cigarette smoke is known to induce small airway inﬂammation (5, 6), which is associated with worse asthma control. Therefore, ICS deposition in small airways, which increases with small- versus standard-size–particle ICS, might be an important determinant of ICS effectiveness in smokers with asthma.

KW - Inhaled Corticosteroids

KW - Smokers

KW - Ex-Smokers

KW - Non Smokers

KW - Differential Effects

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JO - American Journal of Respiratory and Critical Care Medicine

JF - American Journal of Respiratory and Critical Care Medicine

SN - 1073-449X

IS - 8

ER -

Differential effects of inhaled corticosteroids in smokers/ex-smokers and nonsmokers with asthma

Abstract

Keywords

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