Differential expression of CYP1A1, CYP1A2, CYP1B1 in human kidney tumours

Y L Cheung, A C Kerr, M C E McFadyen, W T Melvin, G I Murray

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Abstract

The presence of mRNA of individual members of the CYP1 gene family in normal and neoplastic kidney has been investigated by RTPCR, CYP1B1 mRNA was consistently expressed in both normal and neoplastic kidney while CYP1A1 was present in the majority of normal and neoplastic whereas CYP1A2 was infrequently expressed. Expression of the Ah receptor and Amt which are involved in the transcriptional activation of the CYP1 genes was also studied, The Ah receptor mRNA and Amt mRNA were consistently expressed both in kidney tumours and normal kidney, These results indicate differential expression of individual members of the CYP1 gene family in normal and neoplastic kidney and suggest that several mechanisms including the Ah receptor complex could be involved in their regulation. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)199-205
Number of pages7
JournalCancer Letters
Volume139
Publication statusPublished - 1999

Keywords

  • cytochrome P450
  • Ah receptor
  • kidney cancer
  • neoplasm
  • CYTOCHROME-P450 CYP1B1
  • MESSENGER-RNA
  • HYDROCARBON RECEPTOR
  • HUMAN LIVER
  • GENE
  • ACTIVATION
  • ENZYMES

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