Dimension of pain-related quality of life and self-reported mental health in men and women of the European Prospective Investigation into Cancer–Norfolk cohort

a population-based cross-sectional study

Anna Wiedemann, Adrian D. Wood, Robert N. Luben, Daniel Vogel, Gareth T. Jones, Kay-Tee Khaw, Phyo K. Myint

Research output: Contribution to journalArticle

6 Downloads (Pure)

Abstract

Both cognitive and behavioural factors are linked to the experience of pain as well as its interference with quality of life. Psychological distress has been shown to be associated to several emotional and social impairments. Although, the association between pain and mental health has been widely discussed, the understanding of life interference and outcome is not fully understood. This study examined the association of pain dimension and mental health domain in 16,051 participants of the EPIC-Norfolk cohort (mean age = 58.9 ± 9.1 years). Study outcomes were depressive or anxious behaviour and limitations due to emotional problems and impairments in social functioning (mental functional health components of the Short Form-36 (SF-36)). Logistic regression models were constructed controlling for the potentially confounding factors including socio-economic variables (occupational social class, deprivation, marital status, education), lifestyle behaviour (physical activity, smoking, alcohol, dietary) and previous medical history. Strong interference in quality of life due to pain (bottom 20% of pain dimension score of SF-36) was significantly associated with poor MH in men and women (odds ratios (ORs) (95% confidence intervals (CIs)): 1.35 (1.19, 1.54) and 1.39 (1.25, 1.55), respectively; p < 0.0001) in fully adjusted models. Moreover, strong interference due to pain was also significantly associated with poor overall MH including emotional and social functioning (ORs (95% CIs): 1.42 (1.25, 1.62) and 1.39 (1.25, 1.55) respectively; p < 0.0001) in fully adjusted models; subsidiary analysis using linear regression models demonstrated similar results for these domains. Although a strong association has been shown, further research is needed to provide information on the different site and/or causes of pain which would allow stratification. Moreover, assuming a bi-directional nature of both domains, systematic assessment and management of pain have a lot of potential to improve the MH-related quality of life in the general population and vice versa.
Original languageEnglish
Pages (from-to)35-46
Number of pages12
JournalBritish Journal of Pain
Volume12
Issue number1
Early online date15 Aug 2017
DOIs
Publication statusPublished - 1 Feb 2018

Fingerprint

Mental Health
Cross-Sectional Studies
Quality of Life
Pain
Population
Linear Models
Logistic Models
Odds Ratio
Confidence Intervals
Marital Status
Pain Measurement
Pain Management
Social Class
Life Style
Smoking
Alcohols
Economics
Outcome Assessment (Health Care)
Exercise
Psychology

Keywords

  • pain
  • mental health
  • psychosocial functioning
  • quality of life
  • SF-36

Cite this

@article{4a11a55d9d584d358bdfd2a05b828ffe,
title = "Dimension of pain-related quality of life and self-reported mental health in men and women of the European Prospective Investigation into Cancer–Norfolk cohort: a population-based cross-sectional study",
abstract = "Both cognitive and behavioural factors are linked to the experience of pain as well as its interference with quality of life. Psychological distress has been shown to be associated to several emotional and social impairments. Although, the association between pain and mental health has been widely discussed, the understanding of life interference and outcome is not fully understood. This study examined the association of pain dimension and mental health domain in 16,051 participants of the EPIC-Norfolk cohort (mean age = 58.9 ± 9.1 years). Study outcomes were depressive or anxious behaviour and limitations due to emotional problems and impairments in social functioning (mental functional health components of the Short Form-36 (SF-36)). Logistic regression models were constructed controlling for the potentially confounding factors including socio-economic variables (occupational social class, deprivation, marital status, education), lifestyle behaviour (physical activity, smoking, alcohol, dietary) and previous medical history. Strong interference in quality of life due to pain (bottom 20{\%} of pain dimension score of SF-36) was significantly associated with poor MH in men and women (odds ratios (ORs) (95{\%} confidence intervals (CIs)): 1.35 (1.19, 1.54) and 1.39 (1.25, 1.55), respectively; p < 0.0001) in fully adjusted models. Moreover, strong interference due to pain was also significantly associated with poor overall MH including emotional and social functioning (ORs (95{\%} CIs): 1.42 (1.25, 1.62) and 1.39 (1.25, 1.55) respectively; p < 0.0001) in fully adjusted models; subsidiary analysis using linear regression models demonstrated similar results for these domains. Although a strong association has been shown, further research is needed to provide information on the different site and/or causes of pain which would allow stratification. Moreover, assuming a bi-directional nature of both domains, systematic assessment and management of pain have a lot of potential to improve the MH-related quality of life in the general population and vice versa.",
keywords = "pain, mental health, psychosocial functioning, quality of life, SF-36",
author = "Anna Wiedemann and Wood, {Adrian D.} and Luben, {Robert N.} and Daniel Vogel and Jones, {Gareth T.} and Kay-Tee Khaw and Myint, {Phyo K.}",
note = "Acknowledgement: The authors thank Prof. Gary J Macfarlane, Head of Epidemiology Group, University of Aberdeen, for discussions and constructive comments during manuscript preparation. We also wish to thank the participants of the EPIC-Norfolk cohort, staff, co-PIs, and the funders. The EPIC-Norfolk study was supported by grants from the Cancer Research UK and Medical Research Council (UK). Funders have no role in study design and interpretation of the results. Funding Sources: The EPIC-Norfolk study was supported by grants from the Cancer Research UK (CRUK 14136) and Medical Research Council UK (MRC: G1000143). Funders have no role in study design and interpretation of the results.",
year = "2018",
month = "2",
day = "1",
doi = "10.1177/2049463717724566",
language = "English",
volume = "12",
pages = "35--46",
journal = "British Journal of Pain",
issn = "2049-4637",
publisher = "SAGE Publications Ltd",
number = "1",

}

TY - JOUR

T1 - Dimension of pain-related quality of life and self-reported mental health in men and women of the European Prospective Investigation into Cancer–Norfolk cohort

T2 - a population-based cross-sectional study

AU - Wiedemann, Anna

AU - Wood, Adrian D.

AU - Luben, Robert N.

AU - Vogel, Daniel

AU - Jones, Gareth T.

AU - Khaw, Kay-Tee

AU - Myint, Phyo K.

N1 - Acknowledgement: The authors thank Prof. Gary J Macfarlane, Head of Epidemiology Group, University of Aberdeen, for discussions and constructive comments during manuscript preparation. We also wish to thank the participants of the EPIC-Norfolk cohort, staff, co-PIs, and the funders. The EPIC-Norfolk study was supported by grants from the Cancer Research UK and Medical Research Council (UK). Funders have no role in study design and interpretation of the results. Funding Sources: The EPIC-Norfolk study was supported by grants from the Cancer Research UK (CRUK 14136) and Medical Research Council UK (MRC: G1000143). Funders have no role in study design and interpretation of the results.

PY - 2018/2/1

Y1 - 2018/2/1

N2 - Both cognitive and behavioural factors are linked to the experience of pain as well as its interference with quality of life. Psychological distress has been shown to be associated to several emotional and social impairments. Although, the association between pain and mental health has been widely discussed, the understanding of life interference and outcome is not fully understood. This study examined the association of pain dimension and mental health domain in 16,051 participants of the EPIC-Norfolk cohort (mean age = 58.9 ± 9.1 years). Study outcomes were depressive or anxious behaviour and limitations due to emotional problems and impairments in social functioning (mental functional health components of the Short Form-36 (SF-36)). Logistic regression models were constructed controlling for the potentially confounding factors including socio-economic variables (occupational social class, deprivation, marital status, education), lifestyle behaviour (physical activity, smoking, alcohol, dietary) and previous medical history. Strong interference in quality of life due to pain (bottom 20% of pain dimension score of SF-36) was significantly associated with poor MH in men and women (odds ratios (ORs) (95% confidence intervals (CIs)): 1.35 (1.19, 1.54) and 1.39 (1.25, 1.55), respectively; p < 0.0001) in fully adjusted models. Moreover, strong interference due to pain was also significantly associated with poor overall MH including emotional and social functioning (ORs (95% CIs): 1.42 (1.25, 1.62) and 1.39 (1.25, 1.55) respectively; p < 0.0001) in fully adjusted models; subsidiary analysis using linear regression models demonstrated similar results for these domains. Although a strong association has been shown, further research is needed to provide information on the different site and/or causes of pain which would allow stratification. Moreover, assuming a bi-directional nature of both domains, systematic assessment and management of pain have a lot of potential to improve the MH-related quality of life in the general population and vice versa.

AB - Both cognitive and behavioural factors are linked to the experience of pain as well as its interference with quality of life. Psychological distress has been shown to be associated to several emotional and social impairments. Although, the association between pain and mental health has been widely discussed, the understanding of life interference and outcome is not fully understood. This study examined the association of pain dimension and mental health domain in 16,051 participants of the EPIC-Norfolk cohort (mean age = 58.9 ± 9.1 years). Study outcomes were depressive or anxious behaviour and limitations due to emotional problems and impairments in social functioning (mental functional health components of the Short Form-36 (SF-36)). Logistic regression models were constructed controlling for the potentially confounding factors including socio-economic variables (occupational social class, deprivation, marital status, education), lifestyle behaviour (physical activity, smoking, alcohol, dietary) and previous medical history. Strong interference in quality of life due to pain (bottom 20% of pain dimension score of SF-36) was significantly associated with poor MH in men and women (odds ratios (ORs) (95% confidence intervals (CIs)): 1.35 (1.19, 1.54) and 1.39 (1.25, 1.55), respectively; p < 0.0001) in fully adjusted models. Moreover, strong interference due to pain was also significantly associated with poor overall MH including emotional and social functioning (ORs (95% CIs): 1.42 (1.25, 1.62) and 1.39 (1.25, 1.55) respectively; p < 0.0001) in fully adjusted models; subsidiary analysis using linear regression models demonstrated similar results for these domains. Although a strong association has been shown, further research is needed to provide information on the different site and/or causes of pain which would allow stratification. Moreover, assuming a bi-directional nature of both domains, systematic assessment and management of pain have a lot of potential to improve the MH-related quality of life in the general population and vice versa.

KW - pain

KW - mental health

KW - psychosocial functioning

KW - quality of life

KW - SF-36

U2 - 10.1177/2049463717724566

DO - 10.1177/2049463717724566

M3 - Article

VL - 12

SP - 35

EP - 46

JO - British Journal of Pain

JF - British Journal of Pain

SN - 2049-4637

IS - 1

ER -