Pyrrolizidine alkaloids (PAs) are a group of natural products with important biological activities. The discovery and characterization of the multifunctional FAD‐dependent enzyme LgnC is now described. The enzyme is shown to convert indolizidine intermediates into pyrrolizidines through an unusual ring expansion/contraction mechanism, and catalyze the biosynthesis of new bacterial PAs, the so‐called legonmycins. By genome‐driven analysis, heterologous expression, and gene inactivation, the legonmycins were also shown to originate from non‐ribosomal peptide synthetases (NRPSs). The biosynthetic origin of bacterial PAs has thus been disclosed for the first time.
|Number of pages||5|
|Journal||Angewandte Chemie International Edition|
|Early online date||17 Jul 2015|
|Publication status||Published - 19 Oct 2015|
- multifunctional enzymes
- non-ribosomal peptide synthetases
- pyrrolizidine alkaloids
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- School of Natural & Computing Sciences, Chemistry - Personal Chair
- School of Natural & Computing Sciences, Chemistry - Senior Lecturer