Dissociable deficits in the decision-making cognition of chronic amphetamine abusers, opiate abusers, patients with focal damage to prefrontal cortex, and tryptophan-depleted normal volunteers

Evidence for monoaminergic mechanisms

R D Rogers, B J Everitt, A Baldacchino, A J Blackshaw, Rachel Swainson, K Wynne, N B Baker, J Hunter, T Carthy, E Booker, M London, J F W Deakin, B J Sahakian, T W Robbins

Research output: Contribution to journalArticle

789 Citations (Scopus)

Abstract

We used a novel computerized decision-making task to compare the decision-making behavior of chronic amphetamine abusers, chronic opiate abusers, and patients with focal lesions of orbital prefrontal cortex (PFC) or dorsolateral/medial PFC. We also assessed the effects of reducing central 5-hydroxytryptamine (5-HT) activity using a tryptophan-depleting amino acid drink in normal volunteers. Chronic amphetamine abusers showed sub-optimal decisions (correlated with years of abuse), and deliberated or significantly longer before making their choices. The opiate abusers exhibited only the second of these behavioral changes. Importantly, both sub-optimal choices and increased deliberation times were evident in the patients with damage to orbitofrontal PFC but not other sectors of PFC. Qualitatively, the performance of the subjects with lowered plasma tryptophan was similar to that associated with amphetamine abuse, consistent with recent reports of depleted 5-HT in the orbital regions of PFC of methamphetamine abusers. Overall, these data suggest that chronic amphetamine abusers show similar decision-making deficits to those seen after focal damage to orbitofrontal PFC. These deficits may reflect altered neuromodulation of the orbitofrontal PFC and interconnected limbic-striatal systems by both the ascending 5-HT and mesocortical dopamine (DA) projections. [Neuropsychopharmacology 20:322-339, 1999]. (C) 1999 American College of Neuropsychopharmacology. Published by Elsevier Science Inc.

Original languageEnglish
Pages (from-to)322-339
Number of pages18
JournalNeuropsychopharmacology
Volume20
Issue number4
DOIs
Publication statusPublished - Apr 1999

Keywords

  • amphetamine
  • opiates
  • orbital prefrontal cortex
  • decision making, 5-HT
  • striatal dopamine
  • rat-brain
  • individual vulnerability
  • Parkinsons-Disease
  • glucose-metabolism
  • violent offenders
  • frontal-cortex
  • basal ganglia
  • rhesus-monkey
  • fire setters

Cite this

Dissociable deficits in the decision-making cognition of chronic amphetamine abusers, opiate abusers, patients with focal damage to prefrontal cortex, and tryptophan-depleted normal volunteers : Evidence for monoaminergic mechanisms. / Rogers, R D ; Everitt, B J ; Baldacchino, A ; Blackshaw, A J ; Swainson, Rachel; Wynne, K ; Baker, N B ; Hunter, J ; Carthy, T ; Booker, E ; London, M ; Deakin, J F W ; Sahakian, B J ; Robbins, T W .

In: Neuropsychopharmacology, Vol. 20, No. 4, 04.1999, p. 322-339.

Research output: Contribution to journalArticle

Rogers, R D ; Everitt, B J ; Baldacchino, A ; Blackshaw, A J ; Swainson, Rachel ; Wynne, K ; Baker, N B ; Hunter, J ; Carthy, T ; Booker, E ; London, M ; Deakin, J F W ; Sahakian, B J ; Robbins, T W . / Dissociable deficits in the decision-making cognition of chronic amphetamine abusers, opiate abusers, patients with focal damage to prefrontal cortex, and tryptophan-depleted normal volunteers : Evidence for monoaminergic mechanisms. In: Neuropsychopharmacology. 1999 ; Vol. 20, No. 4. pp. 322-339.
@article{b38af94aa2f64f5189aa3c449dba2028,
title = "Dissociable deficits in the decision-making cognition of chronic amphetamine abusers, opiate abusers, patients with focal damage to prefrontal cortex, and tryptophan-depleted normal volunteers: Evidence for monoaminergic mechanisms",
abstract = "We used a novel computerized decision-making task to compare the decision-making behavior of chronic amphetamine abusers, chronic opiate abusers, and patients with focal lesions of orbital prefrontal cortex (PFC) or dorsolateral/medial PFC. We also assessed the effects of reducing central 5-hydroxytryptamine (5-HT) activity using a tryptophan-depleting amino acid drink in normal volunteers. Chronic amphetamine abusers showed sub-optimal decisions (correlated with years of abuse), and deliberated or significantly longer before making their choices. The opiate abusers exhibited only the second of these behavioral changes. Importantly, both sub-optimal choices and increased deliberation times were evident in the patients with damage to orbitofrontal PFC but not other sectors of PFC. Qualitatively, the performance of the subjects with lowered plasma tryptophan was similar to that associated with amphetamine abuse, consistent with recent reports of depleted 5-HT in the orbital regions of PFC of methamphetamine abusers. Overall, these data suggest that chronic amphetamine abusers show similar decision-making deficits to those seen after focal damage to orbitofrontal PFC. These deficits may reflect altered neuromodulation of the orbitofrontal PFC and interconnected limbic-striatal systems by both the ascending 5-HT and mesocortical dopamine (DA) projections. [Neuropsychopharmacology 20:322-339, 1999]. (C) 1999 American College of Neuropsychopharmacology. Published by Elsevier Science Inc.",
keywords = "amphetamine, opiates, orbital prefrontal cortex, decision making, 5-HT, striatal dopamine, rat-brain, individual vulnerability, Parkinsons-Disease, glucose-metabolism, violent offenders, frontal-cortex, basal ganglia, rhesus-monkey, fire setters",
author = "Rogers, {R D} and Everitt, {B J} and A Baldacchino and Blackshaw, {A J} and Rachel Swainson and K Wynne and Baker, {N B} and J Hunter and T Carthy and E Booker and M London and Deakin, {J F W} and Sahakian, {B J} and Robbins, {T W}",
year = "1999",
month = "4",
doi = "10.1016/S0893-133X(98)00091-8",
language = "English",
volume = "20",
pages = "322--339",
journal = "Neuropsychopharmacology",
issn = "0893-133X",
publisher = "Nature Publishing Group",
number = "4",

}

TY - JOUR

T1 - Dissociable deficits in the decision-making cognition of chronic amphetamine abusers, opiate abusers, patients with focal damage to prefrontal cortex, and tryptophan-depleted normal volunteers

T2 - Evidence for monoaminergic mechanisms

AU - Rogers, R D

AU - Everitt, B J

AU - Baldacchino, A

AU - Blackshaw, A J

AU - Swainson, Rachel

AU - Wynne, K

AU - Baker, N B

AU - Hunter, J

AU - Carthy, T

AU - Booker, E

AU - London, M

AU - Deakin, J F W

AU - Sahakian, B J

AU - Robbins, T W

PY - 1999/4

Y1 - 1999/4

N2 - We used a novel computerized decision-making task to compare the decision-making behavior of chronic amphetamine abusers, chronic opiate abusers, and patients with focal lesions of orbital prefrontal cortex (PFC) or dorsolateral/medial PFC. We also assessed the effects of reducing central 5-hydroxytryptamine (5-HT) activity using a tryptophan-depleting amino acid drink in normal volunteers. Chronic amphetamine abusers showed sub-optimal decisions (correlated with years of abuse), and deliberated or significantly longer before making their choices. The opiate abusers exhibited only the second of these behavioral changes. Importantly, both sub-optimal choices and increased deliberation times were evident in the patients with damage to orbitofrontal PFC but not other sectors of PFC. Qualitatively, the performance of the subjects with lowered plasma tryptophan was similar to that associated with amphetamine abuse, consistent with recent reports of depleted 5-HT in the orbital regions of PFC of methamphetamine abusers. Overall, these data suggest that chronic amphetamine abusers show similar decision-making deficits to those seen after focal damage to orbitofrontal PFC. These deficits may reflect altered neuromodulation of the orbitofrontal PFC and interconnected limbic-striatal systems by both the ascending 5-HT and mesocortical dopamine (DA) projections. [Neuropsychopharmacology 20:322-339, 1999]. (C) 1999 American College of Neuropsychopharmacology. Published by Elsevier Science Inc.

AB - We used a novel computerized decision-making task to compare the decision-making behavior of chronic amphetamine abusers, chronic opiate abusers, and patients with focal lesions of orbital prefrontal cortex (PFC) or dorsolateral/medial PFC. We also assessed the effects of reducing central 5-hydroxytryptamine (5-HT) activity using a tryptophan-depleting amino acid drink in normal volunteers. Chronic amphetamine abusers showed sub-optimal decisions (correlated with years of abuse), and deliberated or significantly longer before making their choices. The opiate abusers exhibited only the second of these behavioral changes. Importantly, both sub-optimal choices and increased deliberation times were evident in the patients with damage to orbitofrontal PFC but not other sectors of PFC. Qualitatively, the performance of the subjects with lowered plasma tryptophan was similar to that associated with amphetamine abuse, consistent with recent reports of depleted 5-HT in the orbital regions of PFC of methamphetamine abusers. Overall, these data suggest that chronic amphetamine abusers show similar decision-making deficits to those seen after focal damage to orbitofrontal PFC. These deficits may reflect altered neuromodulation of the orbitofrontal PFC and interconnected limbic-striatal systems by both the ascending 5-HT and mesocortical dopamine (DA) projections. [Neuropsychopharmacology 20:322-339, 1999]. (C) 1999 American College of Neuropsychopharmacology. Published by Elsevier Science Inc.

KW - amphetamine

KW - opiates

KW - orbital prefrontal cortex

KW - decision making, 5-HT

KW - striatal dopamine

KW - rat-brain

KW - individual vulnerability

KW - Parkinsons-Disease

KW - glucose-metabolism

KW - violent offenders

KW - frontal-cortex

KW - basal ganglia

KW - rhesus-monkey

KW - fire setters

U2 - 10.1016/S0893-133X(98)00091-8

DO - 10.1016/S0893-133X(98)00091-8

M3 - Article

VL - 20

SP - 322

EP - 339

JO - Neuropsychopharmacology

JF - Neuropsychopharmacology

SN - 0893-133X

IS - 4

ER -