Dissociation in response to methylphenidate on response variability in a group of medication naïve children with ADHD

Katherine A Johnson* (Corresponding Author), Edwina Barry, Mark A Bellgrove, Marie Cox, Simon P Kelly, Aoife Daibhis, Michael Daly, Michelle Keavey, Amy Watchorn, Michael Fitzgerald, Fiona McNicholas, Aiveen Kirley, Ian H. Robertson, Michael Gill

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

56 Citations (Scopus)

Abstract

Increased variability in reaction time (RT) has been proposed as a cardinal feature of attention deficit hyperactivity disorder (ADHD). Increased variability during sustained attention tasks may reflect inefficient fronto-striatal and fronto-parietal circuitry; activity within these circuits is modulated by the catecholamines. A disruption to dopamine signaling is suggested in ADHD that may be ameliorated by methylphenidate (MPH). This study investigated the effects of MPH administration on the variability in RT and error performance on a sustained attention task of a group of 31 medication naïve children with ADHD, compared with 22 non-ADHD, non-medicated, control children. All children performed the fixed-sequence sustained attention to response task (SART) at two time-points: at baseline and after six weeks. The children with ADHD were tested when medication naive at baseline and after six weeks of treatment with MPH and whilst on medication. The medication naïve children with ADHD performed the SART with greater errors of commission and omission when compared with the control group. They demonstrated greater standard deviation of RT and fast moment-to-moment variability. They did not differ significantly from the control group in terms of slow variability in RT. MPH administration resulted in reduced and normalised levels of commission errors and fast, moment-to-moment variability in RT. MPH did not affect the rate of omission errors, standard deviation of RT or slow frequency variability in RT. MPH administration may have a specific effect on those performance components that reflect sustained attention and top–down control rather than arousal.

Original languageEnglish
Pages (from-to)1532-1541
Number of pages10
JournalNeuropsychologia
Volume46
Issue number5
Early online date12 Jan 2008
DOIs
Publication statusPublished - 2008

Bibliographical note

This work was supported by grants from the Irish Health Research Board, Science Foundation Ireland, Irish Higher Education Authority's Programme for Research in third-level Institutions. KAJ is supported by the Health Research Board of Ireland. We would like to thank Dr David Hevey for statistical advice, the referring child and adolescent psychiatrists from the Health Service Executive, South Western, Eastern and Midlands areas, the Lucena clinics, and all the participating children and their families.

Keywords

  • response time
  • methylphenidate
  • variability
  • dopamine
  • ADHD

Fingerprint

Dive into the research topics of 'Dissociation in response to methylphenidate on response variability in a group of medication naïve children with ADHD'. Together they form a unique fingerprint.

Cite this