Distribution of HPV types associated with cervical cancers in Scotland and implications for the impact of HPV vaccines

K Cuschieri, D Brewster, A R W Williams, D Millan, G Murray, S Nicoll, J Imrie, A Hardie, C Graham, H Cubie

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Abstract

Background/metho: This study evaluated human papillomavirus (HPV) type prevalence in 370 Scottish invasive cervical cancers (ICCs) using HPV genotyping and HPV mRNA detection.

Results: HPV 16 and/or 18 was detected in 72% of cancers overall and in 82% of HPV-positive cancers. HPV 45 and 16 were the most frequently transcribed types.

Conclusion: A significant reduction in ICC in Scotland should be achieved through the HPV immunisation programme.
Original languageEnglish
Pages (from-to)930-932
Number of pages3
JournalBritish Journal of Cancer
Volume102
Issue number5
Early online date9 Feb 2010
DOIs
Publication statusPublished - 2 Mar 2010

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Keywords

  • HPV
  • genotyping
  • Scotland

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