Diverse effects of stanozolol in C57BL/6J and A/J mouse strains

Arimantas Lionikas, David A Blizard

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Although skeletal muscle is the principal target for androgenic anabolic steroids (AAS) other physiological and behavioral processes are also affected. Wide variations in response to AAS are known to exist in individuals but the genetic basis of this has hardly been explored. Female mice from the A/J and C57BL/6J strains were divided into four experimental groups: CTRL-Sham, housed in a regular mouse cage and subjected to a sham operation mimicking implantation of steroids; CTRL-AAS, mice similarly housed and implanted with a pellet containing stanozolol (release rate, 4.6 mg/kg/day); EX-Sham, sham operated mice housed in a cage with two towers which required mice to climb 1 m to obtain food or water; EX-AAS, mice similarly housed and implanted with a stanozolol pellet. The experimental treatment was initiated at 10 weeks of age and lasted for 7 weeks. Body weight was assessed periodically during the experiment (time effect), systolic blood pressure (BP) and heart rate (HR) were measured after 6 weeks of treatment, and weights of gastrocnemius (GAST), soleus, tibialis anterior (TA), extensor digitorum longus (EDL), quadriceps femoris (QF) and biceps brachii (BB) muscles, heart, liver, kidney and abdominal fat were measured after 7 weeks of treatment. AAS treatment significantly increased weight of GAST (P
Original languageEnglish
Pages (from-to)333-341
Number of pages9
JournalEuropean Journal of Applied Physiology
Volume103
Issue number3
Early online date19 Mar 2008
DOIs
Publication statusPublished - Jun 2008

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Stanozolol
Testosterone Congeners
Physiological Phenomena
Blood Pressure
Weights and Measures
Abdominal Fat
Quadriceps Muscle
Myocardium
Skeletal Muscle
Heart Rate
Steroids
Body Weight
Kidney
Food
Water
Liver

Keywords

  • Abdominal Fat
  • Anabolic Agents
  • Androgens
  • Animals
  • Blood Pressure
  • Body Weight
  • Drug Implants
  • Female
  • Genetic Variation
  • Genotype
  • Heart
  • Heart Rate
  • Kidney
  • Liver
  • Mice
  • Mice, Inbred A
  • Mice, Inbred C57BL
  • Muscle, Skeletal
  • Organ Size
  • Phenotype
  • Physical Exertion
  • Species Specificity
  • Stanozolol

Cite this

Diverse effects of stanozolol in C57BL/6J and A/J mouse strains. / Lionikas, Arimantas; Blizard, David A.

In: European Journal of Applied Physiology, Vol. 103, No. 3, 06.2008, p. 333-341.

Research output: Contribution to journalArticle

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