Diverse Metabolic Profiles of a Streptomyces Strain Isolated from a Hyper-arid Environment

Mostafa E. Rateb, Wael E Houssen, William T. A. Harrison, Hai Deng, Chinyere K. Okoro, Juan A. Asenjo, Barbara A. Andrews, Alan T. Bull, Michael Goodfellow, Rainer Ebel, Marcel Jaspars

Research output: Contribution to journalArticle

74 Citations (Scopus)

Abstract

The metabolic profile of Streptomyces sp. strain C34, isolated from the Chilean hyper-arid Atacama Desert soil, is dependent on the culture media used for its growth. The application of an OSMAC approach on this strain using a range of cultivation media resulted in the isolation and identification of three new compounds from the rare class of 22-membered macrolactone polyketides, named chaxalactins A-C (1-3). In addition, the known compounds deferroxamine E (4), hygromycin A (5), and 5 ''-dihydro-hygromycin A (6) were detected. The isolated compounds were characterized by NMR spectroscopy and accurate mass spectrometric analysis. Compounds 1-3 displayed strong activity against Gram-positive but weak activity Gram-negative strains tested.

Original languageEnglish
Pages (from-to)1965-1971
Number of pages7
JournalJournal of Natural Products
Volume74
Issue number9
Early online date31 Aug 2011
DOIs
Publication statusPublished - 23 Sep 2011

Cite this

Diverse Metabolic Profiles of a Streptomyces Strain Isolated from a Hyper-arid Environment. / Rateb, Mostafa E.; Houssen, Wael E; Harrison, William T. A.; Deng, Hai; Okoro, Chinyere K.; Asenjo, Juan A.; Andrews, Barbara A.; Bull, Alan T.; Goodfellow, Michael; Ebel, Rainer; Jaspars, Marcel.

In: Journal of Natural Products, Vol. 74, No. 9, 23.09.2011, p. 1965-1971.

Research output: Contribution to journalArticle

Rateb, Mostafa E. ; Houssen, Wael E ; Harrison, William T. A. ; Deng, Hai ; Okoro, Chinyere K. ; Asenjo, Juan A. ; Andrews, Barbara A. ; Bull, Alan T. ; Goodfellow, Michael ; Ebel, Rainer ; Jaspars, Marcel. / Diverse Metabolic Profiles of a Streptomyces Strain Isolated from a Hyper-arid Environment. In: Journal of Natural Products. 2011 ; Vol. 74, No. 9. pp. 1965-1971.
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