Diverse Metabolic Profiles of a Streptomyces Strain Isolated from a Hyper-arid Environment

Mostafa E. Rateb, Wael E Houssen, William T. A. Harrison, Hai Deng, Chinyere K. Okoro, Juan A. Asenjo, Barbara A. Andrews, Alan T. Bull, Michael Goodfellow, Rainer Ebel, Marcel Jaspars

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80 Citations (Scopus)

Abstract

The metabolic profile of Streptomyces sp. strain C34, isolated from the Chilean hyper-arid Atacama Desert soil, is dependent on the culture media used for its growth. The application of an OSMAC approach on this strain using a range of cultivation media resulted in the isolation and identification of three new compounds from the rare class of 22-membered macrolactone polyketides, named chaxalactins A-C (1-3). In addition, the known compounds deferroxamine E (4), hygromycin A (5), and 5 ''-dihydro-hygromycin A (6) were detected. The isolated compounds were characterized by NMR spectroscopy and accurate mass spectrometric analysis. Compounds 1-3 displayed strong activity against Gram-positive but weak activity Gram-negative strains tested.

Original languageEnglish
Pages (from-to)1965-1971
Number of pages7
JournalJournal of Natural Products
Volume74
Issue number9
Early online date31 Aug 2011
DOIs
Publication statusPublished - 23 Sep 2011

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