DNA repair in lymphocytes from young and old individuals and from patients with Alzheimer's disease

T A D Smith, R Itzhaki, D Neary

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Lymphocytes from patients with ataxia telangiectasia and Down's syndrome show a greater frequency of chromosome aberrations after ionising radiation than do lymphocytes from normal people. The connection between Down's syndrome and Alzheimer's disease (AD) is well-known. In view of this and of a study showing a greater sensitivity of AD than of normal lymphoblastoid cells to X-irradiation (measured by viability), we have examined repair of AD lymphocytes (hydroxyurea-treated) by measuring [3H]thymidine incorporation after γ-irradiation. We have found no difference in incorporation between AD and normal lymphocytes from age-matched individuals. However, incorporation decreases with age in γ-irradiated cells and to a lesser extent in unirradiated cells.
Original languageEnglish
Pages (from-to)107-112
Number of pages6
JournalMutation Research. DNA Repair
Volume184
Issue number2
DOIs
Publication statusPublished - Sep 1987

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Lymphocytes
DNA Repair
Alzheimer Disease
Repair
DNA
Down Syndrome
Irradiation
Ataxia Telangiectasia
Hydroxyurea
Ionizing radiation
Chromosomes
Ionizing Radiation
Aberrations
Chromosome Aberrations
Thymidine
Cells

Cite this

DNA repair in lymphocytes from young and old individuals and from patients with Alzheimer's disease. / Smith, T A D; Itzhaki, R; Neary, D.

In: Mutation Research. DNA Repair, Vol. 184, No. 2, 09.1987, p. 107-112.

Research output: Contribution to journalArticle

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