Dobutamine magnetic resonance imaging as a predictor of myocardial functional recovery after revascularisation

R J Trent, G D Waiter, G S Hillis, F I McKiddie, T W Redpath, S Walton

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Objective-To assess the use of dobutamine magnetic resonance imaging (MRI) as a preoperative predictor of myocardial functional recovery after revascularisation, comparing wall motion and radial wall thickening analyses by observer and semi-automated edge detection.

Patients-25 men with multivessel coronary disease and resting wall motion abnormalities were studied with preoperative rest and stress MRI.

Main outcome measures-Observer analysis for radial wall thickening was compared with a normal range, while wall motion analysis used a standard four Feint scale. Semi-automated analysis was performed using an edge detection algorithm. Segments displaying either improved or worsened thickening or motion with dobutamine were considered viable. Postoperative rest images were performed 3-6 months after coronary artery bypass grafting (CABG) for comparison.

Results-For observer analysis the values for sensitivity and specificity were 50% and 72% for wall motion, with respective values of 50% and 68% for thickening. With semi-automated edge detection the figures for motion were 60% and 73%, with corresponding values of 79% and 58% for thickening. Combining thickening and motion for the semi-automated method to describe any change in segmental function yielded a sensitivity of 71% and specificity of 70%.

Conclusions-Dobutamine MRI is a reasonably good predictor of myocardial functional recovery after CABG. The use of semi-automated edge detection analysis improved results.

Original languageEnglish
Pages (from-to)40-46
Number of pages7
JournalHeart
Volume83
Publication statusPublished - 2000

Keywords

  • dobutamine
  • magnetic resonance imaging myocardial viability
  • coronary artery bypass grafting
  • CORONARY-ARTERY DISEASE
  • POSITRON EMISSION TOMOGRAPHY
  • LEFT-VENTRICULAR FUNCTION
  • LOW-DOSE DOBUTAMINE
  • SEGMENTED K-SPACE
  • HIBERNATING MYOCARDIUM
  • VIABLE MYOCARDIUM
  • SURGICAL REVASCULARIZATION
  • DYSFUNCTIONAL MYOCARDIUM
  • COMPUTED-TOMOGRAPHY

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