Does a history of depression actually mediate smoking-related pain? Findings from a cross-sectional general population-based study

O. van Hecke*, N. Torrance, L. Cochrane, J. Cavanagh, P. T. Donnan, S. Padmanabhan, D. J. Porteous, L. Hocking, B. H. Smith

*Corresponding author for this work

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

BackgroundSmokers report more pain and worse functioning. The evidence from pain clinics suggests that depression affects this relationship: The association between smoking and chronic pain is weakened when controlling for depression. This study explored the relationship between smoking, pain and depression in a large general population-based cohort (Generation Scotland: Scottish Family Health Study).

MethodsChronic pain measures (intensity, disability), self-reported smoking status and a history of major depressive disorder (MDD) were analysed. A multivariate analysis of covariance determined whether smoking status was associated with both pain measures and a history of depressive illness. Using a statistical mediation model any mediating effect of depression on the relationship between smoking and chronic pain was sought.

ResultsOf all 24,024 participants, 30% (n=7162) reported any chronic pain. Within this chronic pain group, 16% (n=1158) had a history of MDD; 7108 had valid smoking data: 20% (n=1408) were current smokers, 33% (n=2351) former and 47% (n=3349) never smokers. Current smokers demonstrated higher pain intensity and pain-related disability scores compared with former and non-smokers (p

ConclusionsIn contrast to smokers treated in pain clinics, a history of MDD mediated the relationship between smoking and pain intensity, but not pain-related disability in smokers in the community.

Original languageEnglish
Pages (from-to)1223-1230
Number of pages8
JournalEuropean Journal of Pain
Volume18
Issue number9
Early online date27 Feb 2014
DOIs
Publication statusPublished - Oct 2014

Keywords

  • health
  • heritability
  • severity
  • care

Cite this

van Hecke, O., Torrance, N., Cochrane, L., Cavanagh, J., Donnan, P. T., Padmanabhan, S., ... Smith, B. H. (2014). Does a history of depression actually mediate smoking-related pain? Findings from a cross-sectional general population-based study. European Journal of Pain, 18(9), 1223-1230. https://doi.org/10.1002/j.1532-2149.2014.00470.x

Does a history of depression actually mediate smoking-related pain? Findings from a cross-sectional general population-based study. / van Hecke, O.; Torrance, N.; Cochrane, L.; Cavanagh, J.; Donnan, P. T.; Padmanabhan, S.; Porteous, D. J.; Hocking, L.; Smith, B. H.

In: European Journal of Pain, Vol. 18, No. 9, 10.2014, p. 1223-1230.

Research output: Contribution to journalArticle

van Hecke, O, Torrance, N, Cochrane, L, Cavanagh, J, Donnan, PT, Padmanabhan, S, Porteous, DJ, Hocking, L & Smith, BH 2014, 'Does a history of depression actually mediate smoking-related pain? Findings from a cross-sectional general population-based study', European Journal of Pain, vol. 18, no. 9, pp. 1223-1230. https://doi.org/10.1002/j.1532-2149.2014.00470.x
van Hecke, O. ; Torrance, N. ; Cochrane, L. ; Cavanagh, J. ; Donnan, P. T. ; Padmanabhan, S. ; Porteous, D. J. ; Hocking, L. ; Smith, B. H. / Does a history of depression actually mediate smoking-related pain? Findings from a cross-sectional general population-based study. In: European Journal of Pain. 2014 ; Vol. 18, No. 9. pp. 1223-1230.
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abstract = "BackgroundSmokers report more pain and worse functioning. The evidence from pain clinics suggests that depression affects this relationship: The association between smoking and chronic pain is weakened when controlling for depression. This study explored the relationship between smoking, pain and depression in a large general population-based cohort (Generation Scotland: Scottish Family Health Study).MethodsChronic pain measures (intensity, disability), self-reported smoking status and a history of major depressive disorder (MDD) were analysed. A multivariate analysis of covariance determined whether smoking status was associated with both pain measures and a history of depressive illness. Using a statistical mediation model any mediating effect of depression on the relationship between smoking and chronic pain was sought.ResultsOf all 24,024 participants, 30{\%} (n=7162) reported any chronic pain. Within this chronic pain group, 16{\%} (n=1158) had a history of MDD; 7108 had valid smoking data: 20{\%} (n=1408) were current smokers, 33{\%} (n=2351) former and 47{\%} (n=3349) never smokers. Current smokers demonstrated higher pain intensity and pain-related disability scores compared with former and non-smokers (pConclusionsIn contrast to smokers treated in pain clinics, a history of MDD mediated the relationship between smoking and pain intensity, but not pain-related disability in smokers in the community.",
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T1 - Does a history of depression actually mediate smoking-related pain? Findings from a cross-sectional general population-based study

AU - van Hecke, O.

AU - Torrance, N.

AU - Cochrane, L.

AU - Cavanagh, J.

AU - Donnan, P. T.

AU - Padmanabhan, S.

AU - Porteous, D. J.

AU - Hocking, L.

AU - Smith, B. H.

N1 - Funded by Scottish Executive Health Department, Chief Scientist Office under their Genetics and Healthcare Initiative. Grant Number: CZD/16/6 Scottish Funding Council. Grant Number: HR03006

PY - 2014/10

Y1 - 2014/10

N2 - BackgroundSmokers report more pain and worse functioning. The evidence from pain clinics suggests that depression affects this relationship: The association between smoking and chronic pain is weakened when controlling for depression. This study explored the relationship between smoking, pain and depression in a large general population-based cohort (Generation Scotland: Scottish Family Health Study).MethodsChronic pain measures (intensity, disability), self-reported smoking status and a history of major depressive disorder (MDD) were analysed. A multivariate analysis of covariance determined whether smoking status was associated with both pain measures and a history of depressive illness. Using a statistical mediation model any mediating effect of depression on the relationship between smoking and chronic pain was sought.ResultsOf all 24,024 participants, 30% (n=7162) reported any chronic pain. Within this chronic pain group, 16% (n=1158) had a history of MDD; 7108 had valid smoking data: 20% (n=1408) were current smokers, 33% (n=2351) former and 47% (n=3349) never smokers. Current smokers demonstrated higher pain intensity and pain-related disability scores compared with former and non-smokers (pConclusionsIn contrast to smokers treated in pain clinics, a history of MDD mediated the relationship between smoking and pain intensity, but not pain-related disability in smokers in the community.

AB - BackgroundSmokers report more pain and worse functioning. The evidence from pain clinics suggests that depression affects this relationship: The association between smoking and chronic pain is weakened when controlling for depression. This study explored the relationship between smoking, pain and depression in a large general population-based cohort (Generation Scotland: Scottish Family Health Study).MethodsChronic pain measures (intensity, disability), self-reported smoking status and a history of major depressive disorder (MDD) were analysed. A multivariate analysis of covariance determined whether smoking status was associated with both pain measures and a history of depressive illness. Using a statistical mediation model any mediating effect of depression on the relationship between smoking and chronic pain was sought.ResultsOf all 24,024 participants, 30% (n=7162) reported any chronic pain. Within this chronic pain group, 16% (n=1158) had a history of MDD; 7108 had valid smoking data: 20% (n=1408) were current smokers, 33% (n=2351) former and 47% (n=3349) never smokers. Current smokers demonstrated higher pain intensity and pain-related disability scores compared with former and non-smokers (pConclusionsIn contrast to smokers treated in pain clinics, a history of MDD mediated the relationship between smoking and pain intensity, but not pain-related disability in smokers in the community.

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KW - heritability

KW - severity

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DO - 10.1002/j.1532-2149.2014.00470.x

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