Does anticholinergics drug burden relate to global neuro-disability outcome measures and length of hospital stay?

M Sakel, A Boukouvalas, R Buono, M Moten, F Mirza, W-Y Chan, I Maidment, J Cross, T O Smith, P K Myint, C Fox

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

PRIMARY OBJECTIVE: To assess the relationship between disability, length of stay (LOS) and anticholinergic burden (ACB) with people following acquired brain or spinal cord injury.

RESEARCH DESIGN: A retrospective case note review assessed total rehabilitation unit admission.

METHODS AND PROCEDURES: Assessment of 52 consecutive patients with acquired brain/spinal injury and neuropathy in an in-patient neuro-rehabilitation unit of a UK university hospital. Data analysed included: Northwick Park Dependency Score (NPDS), Rehabilitation complexity Scale (RCS), Functional Independence Measure and Functional Assessment Measure FIM-FAM (UK version 2.2), LOS and ACB. Outcome was different in RCS, NPDS and FIM-FAM between admission and discharge.

MAIN OUTCOMES AND RESULTS: A positive change was reported in ACB results in a positive change in NPDS, with no significant effect on FIM-FAM, either Motor or Cognitive, or on the RCS. Change in ACB correlated to the length of hospital stay (regression correlation = -6.64; SE = 3.89). There was a significant harmful impact of increase in ACB score during hospital stay, from low to high ACB on NPDS (OR = 9.65; 95% CI = 1.36-68.64) and FIM-FAM Total scores (OR = 0.03; 95% CI = 0.002-0.35).

CONCLUSIONS: There was a statistically significant correlation of ACB and neuro-disability measures and LOS amongst this patient cohort.

Original languageEnglish
Pages (from-to)1426-1430
Number of pages5
JournalBrain Injury
Volume29
Issue number12
Early online date5 Aug 2015
DOIs
Publication statusPublished - 2015

Fingerprint

Cholinergic Antagonists
Length of Stay
Outcome Assessment (Health Care)
Rehabilitation
Pharmaceutical Preparations
Spinal Injuries
Spinal Cord Injuries
Brain Injuries
Brain

Keywords

  • anticholingeric
  • function
  • rehabilitation unit
  • length of stay
  • adverse effect
  • spinal cord
  • traumatic brain injury

Cite this

Sakel, M., Boukouvalas, A., Buono, R., Moten, M., Mirza, F., Chan, W-Y., ... Fox, C. (2015). Does anticholinergics drug burden relate to global neuro-disability outcome measures and length of hospital stay? Brain Injury, 29(12), 1426-1430. https://doi.org/10.3109/02699052.2015.1060358

Does anticholinergics drug burden relate to global neuro-disability outcome measures and length of hospital stay? / Sakel, M; Boukouvalas, A; Buono, R; Moten, M; Mirza, F; Chan, W-Y; Maidment, I; Cross, J; Smith, T O; Myint, P K; Fox, C.

In: Brain Injury, Vol. 29, No. 12, 2015, p. 1426-1430.

Research output: Contribution to journalArticle

Sakel, M, Boukouvalas, A, Buono, R, Moten, M, Mirza, F, Chan, W-Y, Maidment, I, Cross, J, Smith, TO, Myint, PK & Fox, C 2015, 'Does anticholinergics drug burden relate to global neuro-disability outcome measures and length of hospital stay?' Brain Injury, vol. 29, no. 12, pp. 1426-1430. https://doi.org/10.3109/02699052.2015.1060358
Sakel, M ; Boukouvalas, A ; Buono, R ; Moten, M ; Mirza, F ; Chan, W-Y ; Maidment, I ; Cross, J ; Smith, T O ; Myint, P K ; Fox, C. / Does anticholinergics drug burden relate to global neuro-disability outcome measures and length of hospital stay?. In: Brain Injury. 2015 ; Vol. 29, No. 12. pp. 1426-1430.
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AU - Buono, R

AU - Moten, M

AU - Mirza, F

AU - Chan, W-Y

AU - Maidment, I

AU - Cross, J

AU - Smith, T O

AU - Myint, P K

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