Domestic airborne fine particulate matter exposure and asthma control among children receiving inhaled steroid treatment

K. E. Woods; A. Apsley; S. Semple; S. W. Turner

doi:10.1177/1420326X14527301

Domestic airborne fine particulate matter exposure and asthma control among children receiving inhaled steroid treatment

K. E. Woods, A. Apsley, S. Semple, S. W. Turner^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

The aims of the present study were to measure domestic PM_2.5 exposure and explore relationships with indices of asthma severity and control in children prescribed inhaled corticosteroids (ICSs). Disease severity was determined by questionnaire and spirometry. Asthma control was assessed by 5-day peak flow variability (PFV) and children's asthma control test (CACT) on the 1st and 5th day of peak flow testing. Concentrations of PM_2.5 were measured over a 24-h period. Twenty-two children were recruited, mean age 11.0 years. Across the 22 homes the median time weighted average (TWA) PM _2.5 concentration (range) was 7.4 μg/m³ (2.0-150.0) and was significantly higher in the seven homes where smoking was reported (24.0 μg/m³) than non-smoking homes (6.0 μg/m³), p=0.001. There was a positive association between TWA PM_2.5 and PFV (rho = 0.55, p = 0.015, n = 19) and a negative association between TWA PM_2.5 and CACT (rho = - 0.56, p = 0.010, n = 20). TWA PM_2.5 exposure was not related to indices of asthma severity. Peak PM_2.5 concentration was not associated with any outcome. This exploratory study suggests that even at relatively low concentrations, there is an exposure-response relationship between increasing indoor air PM_2.5 concentrations and poorer asthma control in children prescribed ICSs.

Original language	English
Pages (from-to)	497-503
Number of pages	7
Journal	Indoor and Built Environment
Volume	23
Issue number	3
Early online date	25 Mar 2014
DOIs	https://doi.org/10.1177/1420326X14527301
Publication status	Published - 1 May 2014

Bibliographical note

Funding
This research received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors.

Keywords

Air pollution indoor
Asthma
Child
Respiratory function testing

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1177/1420326X14527301Licence: Unspecified

Cite this

@article{de3cd132a84c49ef9b8e392388d349be,

title = "Domestic airborne fine particulate matter exposure and asthma control among children receiving inhaled steroid treatment",

abstract = "The aims of the present study were to measure domestic PM2.5 exposure and explore relationships with indices of asthma severity and control in children prescribed inhaled corticosteroids (ICSs). Disease severity was determined by questionnaire and spirometry. Asthma control was assessed by 5-day peak flow variability (PFV) and children's asthma control test (CACT) on the 1st and 5th day of peak flow testing. Concentrations of PM2.5 were measured over a 24-h period. Twenty-two children were recruited, mean age 11.0 years. Across the 22 homes the median time weighted average (TWA) PM 2.5 concentration (range) was 7.4 μg/m3 (2.0-150.0) and was significantly higher in the seven homes where smoking was reported (24.0 μg/m3) than non-smoking homes (6.0 μg/m3), p=0.001. There was a positive association between TWA PM2.5 and PFV (rho = 0.55, p = 0.015, n = 19) and a negative association between TWA PM2.5 and CACT (rho = - 0.56, p = 0.010, n = 20). TWA PM2.5 exposure was not related to indices of asthma severity. Peak PM2.5 concentration was not associated with any outcome. This exploratory study suggests that even at relatively low concentrations, there is an exposure-response relationship between increasing indoor air PM2.5 concentrations and poorer asthma control in children prescribed ICSs.",

keywords = "Air pollution indoor, Asthma, Child, Respiratory function testing",

author = "Woods, {K. E.} and A. Apsley and S. Semple and Turner, {S. W.}",

note = "Funding This research received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors.",

year = "2014",

month = may,

day = "1",

doi = "10.1177/1420326X14527301",

language = "English",

volume = "23",

pages = "497--503",

journal = "Indoor and Built Environment",

issn = "1420-326X",

publisher = "SAGE Publications Ltd",

number = "3",

}

TY - JOUR

T1 - Domestic airborne fine particulate matter exposure and asthma control among children receiving inhaled steroid treatment

AU - Woods, K. E.

AU - Apsley, A.

AU - Semple, S.

AU - Turner, S. W.

N1 - Funding This research received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors.

PY - 2014/5/1

Y1 - 2014/5/1

N2 - The aims of the present study were to measure domestic PM2.5 exposure and explore relationships with indices of asthma severity and control in children prescribed inhaled corticosteroids (ICSs). Disease severity was determined by questionnaire and spirometry. Asthma control was assessed by 5-day peak flow variability (PFV) and children's asthma control test (CACT) on the 1st and 5th day of peak flow testing. Concentrations of PM2.5 were measured over a 24-h period. Twenty-two children were recruited, mean age 11.0 years. Across the 22 homes the median time weighted average (TWA) PM 2.5 concentration (range) was 7.4 μg/m3 (2.0-150.0) and was significantly higher in the seven homes where smoking was reported (24.0 μg/m3) than non-smoking homes (6.0 μg/m3), p=0.001. There was a positive association between TWA PM2.5 and PFV (rho = 0.55, p = 0.015, n = 19) and a negative association between TWA PM2.5 and CACT (rho = - 0.56, p = 0.010, n = 20). TWA PM2.5 exposure was not related to indices of asthma severity. Peak PM2.5 concentration was not associated with any outcome. This exploratory study suggests that even at relatively low concentrations, there is an exposure-response relationship between increasing indoor air PM2.5 concentrations and poorer asthma control in children prescribed ICSs.

AB - The aims of the present study were to measure domestic PM2.5 exposure and explore relationships with indices of asthma severity and control in children prescribed inhaled corticosteroids (ICSs). Disease severity was determined by questionnaire and spirometry. Asthma control was assessed by 5-day peak flow variability (PFV) and children's asthma control test (CACT) on the 1st and 5th day of peak flow testing. Concentrations of PM2.5 were measured over a 24-h period. Twenty-two children were recruited, mean age 11.0 years. Across the 22 homes the median time weighted average (TWA) PM 2.5 concentration (range) was 7.4 μg/m3 (2.0-150.0) and was significantly higher in the seven homes where smoking was reported (24.0 μg/m3) than non-smoking homes (6.0 μg/m3), p=0.001. There was a positive association between TWA PM2.5 and PFV (rho = 0.55, p = 0.015, n = 19) and a negative association between TWA PM2.5 and CACT (rho = - 0.56, p = 0.010, n = 20). TWA PM2.5 exposure was not related to indices of asthma severity. Peak PM2.5 concentration was not associated with any outcome. This exploratory study suggests that even at relatively low concentrations, there is an exposure-response relationship between increasing indoor air PM2.5 concentrations and poorer asthma control in children prescribed ICSs.

KW - Air pollution indoor

KW - Asthma

KW - Child

KW - Respiratory function testing

UR - http://www.scopus.com/inward/record.url?scp=84901710976&partnerID=8YFLogxK

U2 - 10.1177/1420326X14527301

DO - 10.1177/1420326X14527301

M3 - Article

AN - SCOPUS:84901710976

SN - 1420-326X

VL - 23

SP - 497

EP - 503

JO - Indoor and Built Environment

JF - Indoor and Built Environment

IS - 3

ER -

Domestic airborne fine particulate matter exposure and asthma control among children receiving inhaled steroid treatment

Abstract

Bibliographical note

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this