Dopamine Autoreceptor Regulation of a Hypothalamic Dopaminergic Network

Stefanos Stagkourakis, Hoseok Kim, David J. Lyons, Christian Broberger

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15 Citations (Scopus)
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Abstract

How autoreceptors contribute to maintaining a stable output of rhythmically active neuronal circuits is poorly understood. Here, we examine this issue in a dopamine population, spontaneously oscillating hypothalamic rat (TIDA) neurons, that underlie neuroendocrine control of reproduction and neuroleptic side effects. Activation of dopamine receptors of the type 2 family (D2Rs) at the cell-body level slowed TIDA oscillations through two mechanisms. First, they prolonged the depolarizing phase through a combination of presynaptic increases in inhibition and postsynaptic hyperpolarization. Second, they extended the discharge phase through presynaptic attenuation of calcium currents and decreased synaptic inhibition. Dopamine reuptake blockade similarly reconfigured the oscillation, indicating that ambient somatodendritic transmitter concentration determines electrical behavior. In the absence of D2R feedback, however, discharge was abolished by depolarization block. These results indicate the existence of an ultra-short feedback loop whereby neuroendocrine dopamine neurons tune network behavior to echoes of their own activity, reflected in ambient somatodendritic dopamine, and also suggest a mechanism for antipsychoticside effects.
Original languageEnglish
Pages (from-to)735-747
Number of pages13
JournalCell Reports
Volume15
Issue number4
Early online date14 Apr 2016
DOIs
Publication statusPublished - 26 Apr 2016

Keywords

  • network oscillation
  • D2 receptor
  • arcuate nucleus
  • tuberoinfundibular
  • auto-inhibition
  • calcium currents
  • prolactin

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    Stagkourakis, S., Kim, H., Lyons, D. J., & Broberger, C. (2016). Dopamine Autoreceptor Regulation of a Hypothalamic Dopaminergic Network. Cell Reports, 15(4), 735-747. https://doi.org/10.1016/j.celrep.2016.03.062