Dopamine boosts memory for angry faces in Parkinson's disease

Leena Subramanian, John Vincent Hindle, Margaret Cecilia Jackson, David E J Linden

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The influence of emotional context on cognitive operations is of fundamental importance for the evolution of higher cognitive functions and their disturbance in neuropsychiatric disorders. The dopamine pathways projecting to prefrontal cortex and the basal ganglia are assumed to play a major role in such emotion-cognition interactions. Here we provide evidence for such a role by studying working memory for emotional faces in patients with Parkinson's Disease. We studied 25 patients with Parkinson's disease during their on and off medication states. Faces with emotional expressions (happy, angry, sad, neutral or fearful) were shown and the participants had to remember and later recall the identity of the faces ignoring the expressions. We found that dopaminergic medication enhances working memory for angry faces and suppresses it for sad faces. The results elucidate neurochemical mechanisms for the saliency of threatening information and support cognitive explanations of the antidepressant effects of dopamine. They also suggest a role for dopamine in changing emotional-cognitive biases rather than as a generic cognitive enhancer.
Original languageEnglish
Pages (from-to)2792-2799
Number of pages8
JournalMovement Disorders
Volume25
Issue number16
Early online date19 Oct 2010
DOIs
Publication statusPublished - 15 Dec 2010

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Parkinson Disease
Dopamine
Short-Term Memory
Cognition
Nootropic Agents
Basal Ganglia
Prefrontal Cortex
Antidepressive Agents
Emotions

Keywords

  • Parkinson's disease
  • dopamine
  • working memory
  • emotional faces
  • emotion-cognition interaction

Cite this

Dopamine boosts memory for angry faces in Parkinson's disease. / Subramanian, Leena; Hindle, John Vincent; Jackson, Margaret Cecilia; Linden, David E J.

In: Movement Disorders, Vol. 25, No. 16, 15.12.2010, p. 2792-2799.

Research output: Contribution to journalArticle

Subramanian, L, Hindle, JV, Jackson, MC & Linden, DEJ 2010, 'Dopamine boosts memory for angry faces in Parkinson's disease', Movement Disorders, vol. 25, no. 16, pp. 2792-2799. https://doi.org/10.1002/mds.23420
Subramanian, Leena ; Hindle, John Vincent ; Jackson, Margaret Cecilia ; Linden, David E J. / Dopamine boosts memory for angry faces in Parkinson's disease. In: Movement Disorders. 2010 ; Vol. 25, No. 16. pp. 2792-2799.
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