Abstract
Background: Dopamine function and reward processing are highly interrelated and involve common brain areas that mainly belong to the mesocorticolimbic pathways. Impairments of both systems have been involved in numerous psychiatric disorders. However, whether alterations in the dopamine system underlie altered reward processing across psychopathologies remains unknown.
Methods: We sought to explore the relationship between dopamine function and reward anticipation in healthy volunteers and psychiatric patients with schizophrenia, depression, and addiction. We performed Positron Emission
Tomography (PET) with [11C]PE2I to assess the dopamine transporter (DAT) availability as a marker of presynaptic dopamine function, and functional MRI (fMRI) using a modified Monetary Incentive Delay task to assess reward related
neural activity. Voxel-based multimodal imaging analysis was performed with SPM software.
Results: Twenty-seven participants were included in the study. Across all participants we found a significant relationship between DAT availability and reward-related activations within the mesolimbic pathway.
Conclusions: We evidenced a direct link between a marker of the dopamine system and reward anticipation, which transcend diagnostic categories in psychiatric patients. The findings underlie the interest of a dimensional approach in psychiatry and the common use of PET and fMRI to assess
dopamine and reward neural networks from molecular to functional level.
Methods: We sought to explore the relationship between dopamine function and reward anticipation in healthy volunteers and psychiatric patients with schizophrenia, depression, and addiction. We performed Positron Emission
Tomography (PET) with [11C]PE2I to assess the dopamine transporter (DAT) availability as a marker of presynaptic dopamine function, and functional MRI (fMRI) using a modified Monetary Incentive Delay task to assess reward related
neural activity. Voxel-based multimodal imaging analysis was performed with SPM software.
Results: Twenty-seven participants were included in the study. Across all participants we found a significant relationship between DAT availability and reward-related activations within the mesolimbic pathway.
Conclusions: We evidenced a direct link between a marker of the dopamine system and reward anticipation, which transcend diagnostic categories in psychiatric patients. The findings underlie the interest of a dimensional approach in psychiatry and the common use of PET and fMRI to assess
dopamine and reward neural networks from molecular to functional level.
| Original language | English |
|---|---|
| Pages | S117-S118 |
| Publication status | Published - 15 May 2017 |
| Event | Society of Biological Psychiatry (SOBP), Annual Scientific Convention and Meeting - San Diego, United States Duration: 15 May 2017 → … |
Conference
| Conference | Society of Biological Psychiatry (SOBP), Annual Scientific Convention and Meeting |
|---|---|
| Country/Territory | United States |
| City | San Diego |
| Period | 15/05/17 → … |
Keywords
- Dopamine transporter
- Reward
- Multimodal neuroimaging
- Dimensional