Dopamine Transporter and Reward Anticipation in Psychiatric Patients: A Positron Emission Tomography and Functional Magnetic Resonance Imaging Study

Manon Dubol, Christian Trichard, Anca-Larisa Sandu-Giuraniuc, Claire Leroy, Mehdi Rahim, Jean-Luc Martinot, Eric Artiges

Research output: Contribution to conferenceAbstract

Abstract

Background: Dopamine function and reward processing are highly interrelated and involve common brain areas that mainly belong to the mesocorticolimbic pathways. Impairments of both systems have been involved in numerous psychiatric disorders. However, whether alterations in the dopamine system underlie altered reward processing across psychopathologies remains unknown.
Methods: We sought to explore the relationship between dopamine function and reward anticipation in healthy volunteers and psychiatric patients with schizophrenia, depression, and addiction. We performed Positron Emission
Tomography (PET) with [11C]PE2I to assess the dopamine transporter (DAT) availability as a marker of presynaptic dopamine function, and functional MRI (fMRI) using a modified Monetary Incentive Delay task to assess reward related
neural activity. Voxel-based multimodal imaging analysis was performed with SPM software.
Results: Twenty-seven participants were included in the study. Across all participants we found a significant relationship between DAT availability and reward-related activations within the mesolimbic pathway.
Conclusions: We evidenced a direct link between a marker of the dopamine system and reward anticipation, which transcend diagnostic categories in psychiatric patients. The findings underlie the interest of a dimensional approach in psychiatry and the common use of PET and fMRI to assess
dopamine and reward neural networks from molecular to functional level.
Original languageEnglish
PagesS117-S118
Publication statusPublished - 15 May 2017
EventSociety of Biological Psychiatry (SOBP), Annual Scientific Convention and Meeting - San Diego, United States
Duration: 15 May 2017 → …

Conference

ConferenceSociety of Biological Psychiatry (SOBP), Annual Scientific Convention and Meeting
CountryUnited States
CitySan Diego
Period15/05/17 → …

Keywords

  • Dopamine transporter
  • Reward
  • Multimodal neuroimaging
  • Dimensional

Fingerprint Dive into the research topics of 'Dopamine Transporter and Reward Anticipation in Psychiatric Patients: A Positron Emission Tomography and Functional Magnetic Resonance Imaging Study'. Together they form a unique fingerprint.

Cite this