Dopamine transporter (DAT1) and dopamine receptor D4 (DRD4) genotypes differentially impact on electrophysiological correlates of error processing

Stefanie C Biehl (Corresponding Author), Thomas Dresler, Andreas Reif, Peter Scheuerpflug, Jürgen Deckert, Martin J Herrmann

Research output: Contribution to journalArticle

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Abstract

Recent studies as well as theoretical models of error processing assign fundamental importance to the brain's dopaminergic system. Research about how the electrophysiological correlates of error processing--the error-related negativity (ERN) and the error positivity (Pe)--are influenced by variations of common dopaminergic genes, however, is still relatively scarce. In the present study, we therefore investigated whether polymorphisms in the DAT1 gene and in the DRD4 gene, respectively, lead to interindividual differences in these error processing correlates. One hundred sixty participants completed a version of the Eriksen Flanker Task while a 26-channel EEG was recorded. The task was slightly modified in order to increase error rates. During data analysis, participants were split into two groups depending on their DAT1 and their DRD4 genotypes, respectively. ERN and Pe amplitudes after correct responses and after errors as well as difference amplitudes between errors and correct responses were analyzed. We found a differential effect of DAT1 genotype on the Pe difference amplitude but not on the ERN difference amplitude, while the reverse was true for DRD4 genotype. These findings are in line with predictions from theoretical models of dopaminergic transmission in the brain. They furthermore tie results from clinical investigations of disorders impacting on the dopamine system to genetic variations known to be at-risk genotypes.
Original languageEnglish
Article numbere28396
Number of pages6
JournalPloS ONE
Volume6
Issue number12
DOIs
Publication statusPublished - 5 Dec 2011

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Dopamine Plasma Membrane Transport Proteins
Dopamine D4 Receptors
Dopamine Receptors
dopamine
transporters
Genotype
genotype
Processing
Theoretical Models
Genes
brain
genes
Brain
Electroencephalography
Dopamine
data analysis
genetic polymorphism
genetic variation
prediction
dopamine receptors

Keywords

  • adult
  • behavior
  • brain
  • dopamine
  • dopamine plasma membrane transport proteins
  • electrophysiology
  • female
  • gene expression regulation
  • genetic variation
  • genotype
  • humans
  • male
  • middle aged
  • models, biological
  • psychomotor performance
  • receptors, dopamine D4
  • reproducibility of results

Cite this

Dopamine transporter (DAT1) and dopamine receptor D4 (DRD4) genotypes differentially impact on electrophysiological correlates of error processing. / Biehl, Stefanie C (Corresponding Author); Dresler, Thomas; Reif, Andreas; Scheuerpflug, Peter; Deckert, Jürgen; Herrmann, Martin J.

In: PloS ONE, Vol. 6, No. 12, e28396, 05.12.2011.

Research output: Contribution to journalArticle

Biehl, Stefanie C ; Dresler, Thomas ; Reif, Andreas ; Scheuerpflug, Peter ; Deckert, Jürgen ; Herrmann, Martin J. / Dopamine transporter (DAT1) and dopamine receptor D4 (DRD4) genotypes differentially impact on electrophysiological correlates of error processing. In: PloS ONE. 2011 ; Vol. 6, No. 12.
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