Dopaminergic genotype biases spatial attention in healthy children

M A Bellgrove, C D Chambers, K A Johnson, A Daibhis, Michael Daly, Z Hawi, D Lambert, M Gill, I H Robertson

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

In everyday life, our sensory system is bombarded with visual input and we rely upon attention to select only those inputs that are relevant to behavioural goals. Typically, humans can shift their attention from one visual field to the other with little cost to perception. In cases of 'unilateral neglect', however, there is a persistent bias of spatial attention towards the same side as the damaged cerebral hemisphere. We used a visual orienting task to examine the influence of functional polymorphisms of the dopamine transporter gene (DAT1) on individual differences in spatial attention in normally developing children. DAT1 genotype significantly influenced spatial bias. Healthy children who were homozygous for alleles that influence the expression of dopamine transporters in the brain displayed inattention for left-sided stimuli, whereas heterozygotes did not. Our data provide the first evidence in healthy individuals of a genetically mediated bias in spatial attention that is related to dopamine signalling.

Original languageEnglish
Pages (from-to)786-792
Number of pages7
JournalMolecular Psychiatry
Volume12
Issue number8
Early online date5 Jun 2007
DOIs
Publication statusPublished - Aug 2007

Fingerprint

Genotype
Dopamine Plasma Membrane Transport Proteins
Cerebrum
Heterozygote
Visual Fields
Individuality
Dopamine
Alleles
Costs and Cost Analysis
Brain
Genes

Keywords

  • dopamine
  • DAT1
  • attention
  • ADHD
  • spatial attention
  • directed attention

Cite this

Bellgrove, M. A., Chambers, C. D., Johnson, K. A., Daibhis, A., Daly, M., Hawi, Z., ... Robertson, I. H. (2007). Dopaminergic genotype biases spatial attention in healthy children. Molecular Psychiatry, 12(8), 786-792. https://doi.org/10.1038/sj.mp.4002022

Dopaminergic genotype biases spatial attention in healthy children. / Bellgrove, M A ; Chambers, C D; Johnson, K A ; Daibhis, A; Daly, Michael; Hawi, Z; Lambert, D; Gill, M; Robertson, I H.

In: Molecular Psychiatry, Vol. 12, No. 8, 08.2007, p. 786-792.

Research output: Contribution to journalArticle

Bellgrove, MA, Chambers, CD, Johnson, KA, Daibhis, A, Daly, M, Hawi, Z, Lambert, D, Gill, M & Robertson, IH 2007, 'Dopaminergic genotype biases spatial attention in healthy children', Molecular Psychiatry, vol. 12, no. 8, pp. 786-792. https://doi.org/10.1038/sj.mp.4002022
Bellgrove MA, Chambers CD, Johnson KA, Daibhis A, Daly M, Hawi Z et al. Dopaminergic genotype biases spatial attention in healthy children. Molecular Psychiatry. 2007 Aug;12(8):786-792. https://doi.org/10.1038/sj.mp.4002022
Bellgrove, M A ; Chambers, C D ; Johnson, K A ; Daibhis, A ; Daly, Michael ; Hawi, Z ; Lambert, D ; Gill, M ; Robertson, I H. / Dopaminergic genotype biases spatial attention in healthy children. In: Molecular Psychiatry. 2007 ; Vol. 12, No. 8. pp. 786-792.
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