Drimane sesquiterpenoids from the fungus Aspergillus ustus isolated from the marine sponge Suberites domuncula

H. Liu, R. Edrada-Ebel, R. Ebel, Y. Wang, B. Schulz, S. Draeger, W.E.G. Müller, V. Wray, W. Lin, P. Proksch

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Seven new drimane sesquiterpenoids (1-3, 6-9), along with the known compounds deoxyuvidin B (4), strobilactone B (5), and RES-1149-2 (10), were obtained from cultures of the fungus Aspergillus ustus, which was isolated from the marine sponge Suberites domuncula. Their structures were established by means of spectroscopic analyses including one- and two-dimensional NMR spectroscopy and high-resolution MS. Compounds 6, 7, and 10 showed cytotoxic activity against a panel of tumor cell lines, including L5178Y, HeLa, and PC12 cells, with 7 being the most active (EC50 against L5178Y cell line: 0.6 µg/mL).
Original languageEnglish
Pages (from-to)1585-1588
Number of pages4
JournalJournal of Natural Products
Volume72
Issue number9
Early online date14 Aug 2009
DOIs
Publication statusPublished - 2009

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Suberites
Aspergillus
PC12 Cells
Porifera
Tumor Cell Line
Fungi
HeLa Cells
Magnetic Resonance Spectroscopy
Cells
Cell Line
Nuclear magnetic resonance spectroscopy
Tumors
RES 1149-2
drimane

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Drimane sesquiterpenoids from the fungus Aspergillus ustus isolated from the marine sponge Suberites domuncula. / Liu, H.; Edrada-Ebel, R.; Ebel, R.; Wang, Y.; Schulz, B.; Draeger, S.; Müller, W.E.G.; Wray, V.; Lin, W.; Proksch, P.

In: Journal of Natural Products, Vol. 72, No. 9, 2009, p. 1585-1588.

Research output: Contribution to journalArticle

Liu, H, Edrada-Ebel, R, Ebel, R, Wang, Y, Schulz, B, Draeger, S, Müller, WEG, Wray, V, Lin, W & Proksch, P 2009, 'Drimane sesquiterpenoids from the fungus Aspergillus ustus isolated from the marine sponge Suberites domuncula', Journal of Natural Products, vol. 72, no. 9, pp. 1585-1588. https://doi.org/10.1021/np900220r
Liu, H. ; Edrada-Ebel, R. ; Ebel, R. ; Wang, Y. ; Schulz, B. ; Draeger, S. ; Müller, W.E.G. ; Wray, V. ; Lin, W. ; Proksch, P. / Drimane sesquiterpenoids from the fungus Aspergillus ustus isolated from the marine sponge Suberites domuncula. In: Journal of Natural Products. 2009 ; Vol. 72, No. 9. pp. 1585-1588.
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