TY - JOUR
T1 - Drimane sesquiterpenoids from the fungus Aspergillus ustus isolated from the marine sponge Suberites domuncula
AU - Liu, H.
AU - Edrada-Ebel, R.
AU - Ebel, R.
AU - Wang, Y.
AU - Schulz, B.
AU - Draeger, S.
AU - Müller, W.E.G.
AU - Wray, V.
AU - Lin, W.
AU - Proksch, P.
N1 - MEDLINE® is the source for the MeSH terms of this document.
PY - 2009
Y1 - 2009
N2 - Seven new drimane sesquiterpenoids (1-3, 6-9), along with the known compounds deoxyuvidin B (4), strobilactone B (5), and RES-1149-2 (10), were obtained from cultures of the fungus Aspergillus ustus, which was isolated from the marine sponge Suberites domuncula. Their structures were established by means of spectroscopic analyses including one- and two-dimensional NMR spectroscopy and high-resolution MS. Compounds 6, 7, and 10 showed cytotoxic activity against a panel of tumor cell lines, including L5178Y, HeLa, and PC12 cells, with 7 being the most active (EC50 against L5178Y cell line: 0.6 µg/mL).
AB - Seven new drimane sesquiterpenoids (1-3, 6-9), along with the known compounds deoxyuvidin B (4), strobilactone B (5), and RES-1149-2 (10), were obtained from cultures of the fungus Aspergillus ustus, which was isolated from the marine sponge Suberites domuncula. Their structures were established by means of spectroscopic analyses including one- and two-dimensional NMR spectroscopy and high-resolution MS. Compounds 6, 7, and 10 showed cytotoxic activity against a panel of tumor cell lines, including L5178Y, HeLa, and PC12 cells, with 7 being the most active (EC50 against L5178Y cell line: 0.6 µg/mL).
UR - http://www.scopus.com/inward/record.url?scp=70349515534&partnerID=8YFLogxK
U2 - 10.1021/np900220r
DO - 10.1021/np900220r
M3 - Article
AN - SCOPUS:70349515534
VL - 72
SP - 1585
EP - 1588
JO - Journal of Natural Products
JF - Journal of Natural Products
SN - 0163-3864
IS - 9
ER -
