Seven new drimane sesquiterpenoids (1-3, 6-9), along with the known compounds deoxyuvidin B (4), strobilactone B (5), and RES-1149-2 (10), were obtained from cultures of the fungus Aspergillus ustus, which was isolated from the marine sponge Suberites domuncula. Their structures were established by means of spectroscopic analyses including one- and two-dimensional NMR spectroscopy and high-resolution MS. Compounds 6, 7, and 10 showed cytotoxic activity against a panel of tumor cell lines, including L5178Y, HeLa, and PC12 cells, with 7 being the most active (EC50 against L5178Y cell line: 0.6 µg/mL).
Liu, H., Edrada-Ebel, R., Ebel, R., Wang, Y., Schulz, B., Draeger, S., Müller, W. E. G., Wray, V., Lin, W., & Proksch, P. (2009). Drimane sesquiterpenoids from the fungus Aspergillus ustus isolated from the marine sponge Suberites domuncula. Journal of Natural Products, 72(9), 1585-1588. https://doi.org/10.1021/np900220r