DXA-derived hip shape is related to osteoarthritis

findings from in the MrOS cohort

Ben Faber, Denis Baird, Celia Gregson, Jennifer Susan Gregory, R Y Barr, Richard Malcolm Aspden, John Lynch, Michael Nevitt, Nancy E. Lane, Eric Orwoll, Jon Tobias

Research output: Contribution to journalArticle

6 Citations (Scopus)
3 Downloads (Pure)

Abstract

Objective: Statistical shape modeling (SSM) of radiographs has been used to explore relationships between altered joint shape and hip osteoarthritis (OA). We aimed to apply SSM to Dual-energy X-ray Absorptiometry (DXA) hip scans, and examine associations between resultant hip shape modes (HSMs), radiographic hip OA (RHOA), and hip pain, in a large population based cohort.

Method: SSM was performed on baseline hip DXA scans from the Osteoporotic Fractures in Men (MrOS) Study. Associations between the top ten HSMs, and prevalent RHOA from pelvic radiographs obtained 4.6 years later, were analysed in 4100 participants. RHOA was defined as Croft score ≥ 2. Hip pain was based on pain on walking, hip pain on examination, and Western Ontario and McMaster Universities Arthritis Index (WOMAC).

Results: The five HSMs associated with RHOA showed features of either pincer- or cam-type deformities. HSM 1 (increased pincer-type deformity) was positively associated with RHOA [1.23 (1.09,1.39)] [odds ratio and 95% CI]. HSM 8 (reduced pincer-type deformity) was inversely associated with RHOA [0.79 (0.70,0.89)]. HSM 10 (increased cam-type deformity) was positively associated with RHOA [1.21 (1.07,1.37)]. HSM 3 and HSM 4 (reduced cam-type deformity) were inversely associated with RHOA [0.73 (0.65,0.83) and 0.82 (0.73,0.93) respectively]. HSM 3 was inversely related to pain on examination [0.84 (0.76,0.92)] and walking [0.88, (0.81,0.95)], and to WOMAC score [0.87 (0.80,0.93)].

Conclusions: DXA-derived measures of hip shape are associated with RHOA, and to a lesser extent hip pain, possibly reflecting their role in the pathogenesis of hip OA.
Original languageEnglish
Pages (from-to)2031-2038
Number of pages8
JournalOsteoarthritis and Cartilage
Volume25
Issue number12
Early online date21 Sep 2017
DOIs
Publication statusPublished - Dec 2017

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Cams
Photon Absorptiometry
Osteoarthritis
Hip
X rays
Statistical methods
Hip Osteoarthritis
Pain
Walking

Keywords

  • hip shape
  • joint shape
  • active shape modeling

Cite this

DXA-derived hip shape is related to osteoarthritis : findings from in the MrOS cohort. / Faber, Ben; Baird, Denis; Gregson, Celia; Gregory, Jennifer Susan; Barr, R Y; Aspden, Richard Malcolm; Lynch, John; Nevitt, Michael; Lane, Nancy E.; Orwoll, Eric; Tobias, Jon.

In: Osteoarthritis and Cartilage, Vol. 25, No. 12, 12.2017, p. 2031-2038.

Research output: Contribution to journalArticle

Faber, B, Baird, D, Gregson, C, Gregory, JS, Barr, RY, Aspden, RM, Lynch, J, Nevitt, M, Lane, NE, Orwoll, E & Tobias, J 2017, 'DXA-derived hip shape is related to osteoarthritis: findings from in the MrOS cohort', Osteoarthritis and Cartilage, vol. 25, no. 12, pp. 2031-2038. https://doi.org/10.1016/j.joca.2017.09.006
Faber, Ben ; Baird, Denis ; Gregson, Celia ; Gregory, Jennifer Susan ; Barr, R Y ; Aspden, Richard Malcolm ; Lynch, John ; Nevitt, Michael ; Lane, Nancy E. ; Orwoll, Eric ; Tobias, Jon. / DXA-derived hip shape is related to osteoarthritis : findings from in the MrOS cohort. In: Osteoarthritis and Cartilage. 2017 ; Vol. 25, No. 12. pp. 2031-2038.
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abstract = "Objective: Statistical shape modeling (SSM) of radiographs has been used to explore relationships between altered joint shape and hip osteoarthritis (OA). We aimed to apply SSM to Dual-energy X-ray Absorptiometry (DXA) hip scans, and examine associations between resultant hip shape modes (HSMs), radiographic hip OA (RHOA), and hip pain, in a large population based cohort.Method: SSM was performed on baseline hip DXA scans from the Osteoporotic Fractures in Men (MrOS) Study. Associations between the top ten HSMs, and prevalent RHOA from pelvic radiographs obtained 4.6 years later, were analysed in 4100 participants. RHOA was defined as Croft score ≥ 2. Hip pain was based on pain on walking, hip pain on examination, and Western Ontario and McMaster Universities Arthritis Index (WOMAC).Results: The five HSMs associated with RHOA showed features of either pincer- or cam-type deformities. HSM 1 (increased pincer-type deformity) was positively associated with RHOA [1.23 (1.09,1.39)] [odds ratio and 95{\%} CI]. HSM 8 (reduced pincer-type deformity) was inversely associated with RHOA [0.79 (0.70,0.89)]. HSM 10 (increased cam-type deformity) was positively associated with RHOA [1.21 (1.07,1.37)]. HSM 3 and HSM 4 (reduced cam-type deformity) were inversely associated with RHOA [0.73 (0.65,0.83) and 0.82 (0.73,0.93) respectively]. HSM 3 was inversely related to pain on examination [0.84 (0.76,0.92)] and walking [0.88, (0.81,0.95)], and to WOMAC score [0.87 (0.80,0.93)].Conclusions: DXA-derived measures of hip shape are associated with RHOA, and to a lesser extent hip pain, possibly reflecting their role in the pathogenesis of hip OA.",
keywords = "hip shape, joint shape, active shape modeling",
author = "Ben Faber and Denis Baird and Celia Gregson and Gregory, {Jennifer Susan} and Barr, {R Y} and Aspden, {Richard Malcolm} and John Lynch and Michael Nevitt and Lane, {Nancy E.} and Eric Orwoll and Jon Tobias",
note = "BF conducted this research whilst on a clinical research primer fellowship awarded by the Elizabeth Blackwell Institute, University of Bristol, UK. This study was funded by Arthritis Research UK project grant ref 20244. CG is funded by Arthritis Research UK grant ref 20000. The Osteoporotic Fractures in Men (MrOS) Study is supported by National Institutes of Health funding. The following institutes provide support: the National Institute on Aging (NIA), the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), the National Center for Advancing Translational Sciences (NCATS), and NIH Roadmap for Medical Research under the following grant numbers: R01 AR052000, K24 AR048841, U01 AG027810, U01 AG042124, U01 AG042139, U01 AG042140, U01 AG042143, U01 AG042145, U01 AG042168, U01 AR066160, and UL1 TR000128.",
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TY - JOUR

T1 - DXA-derived hip shape is related to osteoarthritis

T2 - findings from in the MrOS cohort

AU - Faber, Ben

AU - Baird, Denis

AU - Gregson, Celia

AU - Gregory, Jennifer Susan

AU - Barr, R Y

AU - Aspden, Richard Malcolm

AU - Lynch, John

AU - Nevitt, Michael

AU - Lane, Nancy E.

AU - Orwoll, Eric

AU - Tobias, Jon

N1 - BF conducted this research whilst on a clinical research primer fellowship awarded by the Elizabeth Blackwell Institute, University of Bristol, UK. This study was funded by Arthritis Research UK project grant ref 20244. CG is funded by Arthritis Research UK grant ref 20000. The Osteoporotic Fractures in Men (MrOS) Study is supported by National Institutes of Health funding. The following institutes provide support: the National Institute on Aging (NIA), the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), the National Center for Advancing Translational Sciences (NCATS), and NIH Roadmap for Medical Research under the following grant numbers: R01 AR052000, K24 AR048841, U01 AG027810, U01 AG042124, U01 AG042139, U01 AG042140, U01 AG042143, U01 AG042145, U01 AG042168, U01 AR066160, and UL1 TR000128.

PY - 2017/12

Y1 - 2017/12

N2 - Objective: Statistical shape modeling (SSM) of radiographs has been used to explore relationships between altered joint shape and hip osteoarthritis (OA). We aimed to apply SSM to Dual-energy X-ray Absorptiometry (DXA) hip scans, and examine associations between resultant hip shape modes (HSMs), radiographic hip OA (RHOA), and hip pain, in a large population based cohort.Method: SSM was performed on baseline hip DXA scans from the Osteoporotic Fractures in Men (MrOS) Study. Associations between the top ten HSMs, and prevalent RHOA from pelvic radiographs obtained 4.6 years later, were analysed in 4100 participants. RHOA was defined as Croft score ≥ 2. Hip pain was based on pain on walking, hip pain on examination, and Western Ontario and McMaster Universities Arthritis Index (WOMAC).Results: The five HSMs associated with RHOA showed features of either pincer- or cam-type deformities. HSM 1 (increased pincer-type deformity) was positively associated with RHOA [1.23 (1.09,1.39)] [odds ratio and 95% CI]. HSM 8 (reduced pincer-type deformity) was inversely associated with RHOA [0.79 (0.70,0.89)]. HSM 10 (increased cam-type deformity) was positively associated with RHOA [1.21 (1.07,1.37)]. HSM 3 and HSM 4 (reduced cam-type deformity) were inversely associated with RHOA [0.73 (0.65,0.83) and 0.82 (0.73,0.93) respectively]. HSM 3 was inversely related to pain on examination [0.84 (0.76,0.92)] and walking [0.88, (0.81,0.95)], and to WOMAC score [0.87 (0.80,0.93)].Conclusions: DXA-derived measures of hip shape are associated with RHOA, and to a lesser extent hip pain, possibly reflecting their role in the pathogenesis of hip OA.

AB - Objective: Statistical shape modeling (SSM) of radiographs has been used to explore relationships between altered joint shape and hip osteoarthritis (OA). We aimed to apply SSM to Dual-energy X-ray Absorptiometry (DXA) hip scans, and examine associations between resultant hip shape modes (HSMs), radiographic hip OA (RHOA), and hip pain, in a large population based cohort.Method: SSM was performed on baseline hip DXA scans from the Osteoporotic Fractures in Men (MrOS) Study. Associations between the top ten HSMs, and prevalent RHOA from pelvic radiographs obtained 4.6 years later, were analysed in 4100 participants. RHOA was defined as Croft score ≥ 2. Hip pain was based on pain on walking, hip pain on examination, and Western Ontario and McMaster Universities Arthritis Index (WOMAC).Results: The five HSMs associated with RHOA showed features of either pincer- or cam-type deformities. HSM 1 (increased pincer-type deformity) was positively associated with RHOA [1.23 (1.09,1.39)] [odds ratio and 95% CI]. HSM 8 (reduced pincer-type deformity) was inversely associated with RHOA [0.79 (0.70,0.89)]. HSM 10 (increased cam-type deformity) was positively associated with RHOA [1.21 (1.07,1.37)]. HSM 3 and HSM 4 (reduced cam-type deformity) were inversely associated with RHOA [0.73 (0.65,0.83) and 0.82 (0.73,0.93) respectively]. HSM 3 was inversely related to pain on examination [0.84 (0.76,0.92)] and walking [0.88, (0.81,0.95)], and to WOMAC score [0.87 (0.80,0.93)].Conclusions: DXA-derived measures of hip shape are associated with RHOA, and to a lesser extent hip pain, possibly reflecting their role in the pathogenesis of hip OA.

KW - hip shape

KW - joint shape

KW - active shape modeling

U2 - 10.1016/j.joca.2017.09.006

DO - 10.1016/j.joca.2017.09.006

M3 - Article

VL - 25

SP - 2031

EP - 2038

JO - Osteoarthritis and Cartilage

JF - Osteoarthritis and Cartilage

SN - 1063-4584

IS - 12

ER -