Dynamic changes of the extracellular matrix after acute tako-tsubo cardiomyopathy

Trevor Ahearn; Baljit Jagpal; Donnie Cameron; Bernice K. Ng; Caroline Scally; David M. Higgins; John Horowitz; Michael P. Frenneaux; Dana K. Dawson

doi:10.1186/1532-429X-17-S1-P259

Abstract

Background
We have recently demonstrated that cardiac energetic impairment and global myocardial edema persists for at least 4 months after an acute episode of Tako-tsubo cardiomyopathy (TTC). The aim of the current study was to evaluate the regional edema acutely and the status of the extracellular matrix at follow up

Methods
Eleven patients (10F, mean age 56±16yrs) with a clear diagnosis of ST-elevation TTC and emotional trigger were prospectively enrolled and underwent cardiac magnetic resonance acutely (day 0-3) and after 4 months on a Philips 3T Achieva scanner. Native 3-3-5 (MOLLI) T1 mapping was applied acutely, and both native and post-contrast T1 mapping were performed at 4 months follow-up. Eleven healthy controls underwent only native T1 mapping. T1 maps were: generated using in-house software - written in IDL (Exelis. Boulder CO, USA); quality controlled with chi-square maps; and imported into Segment (Medviso, Lund University, Sweden), where T1 values were generated for 16 segments. Extracellular volumes (ECV) were calculated for the follow-up scan using:

ECV=(1-hermatocrit)(ΔR1myocardium/ ΔR1blood)

Segments were grouped according to their wall motion (WM) on the acute scan (normal/abnormal).

Original language	English
Article number	P259
Number of pages	1
Journal	Journal of Cardiovascular Magnetic Resonance
Volume	17
Issue number	Suppl. 1
DOIs	https://doi.org/10.1186/1532-429X-17-S1-P259
Publication status	Published - 3 Feb 2015

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10.1186/1532-429X-17-S1-P259Licence: CC BY

Dynamic changes of the extracellular matrix after acute tako-tsubo cardiomyopathy
© Ahearn et al; licensee BioMed Central Ltd. 2015 This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
Final published version, 147 KBLicence: CC BY

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@article{709e56108ba14e3bb156db41b6cdb6f8,

title = "Dynamic changes of the extracellular matrix after acute tako-tsubo cardiomyopathy",

abstract = "BackgroundWe have recently demonstrated that cardiac energetic impairment and global myocardial edema persists for at least 4 months after an acute episode of Tako-tsubo cardiomyopathy (TTC). The aim of the current study was to evaluate the regional edema acutely and the status of the extracellular matrix at follow upMethodsEleven patients (10F, mean age 56±16yrs) with a clear diagnosis of ST-elevation TTC and emotional trigger were prospectively enrolled and underwent cardiac magnetic resonance acutely (day 0-3) and after 4 months on a Philips 3T Achieva scanner. Native 3-3-5 (MOLLI) T1 mapping was applied acutely, and both native and post-contrast T1 mapping were performed at 4 months follow-up. Eleven healthy controls underwent only native T1 mapping. T1 maps were: generated using in-house software - written in IDL (Exelis. Boulder CO, USA); quality controlled with chi-square maps; and imported into Segment (Medviso, Lund University, Sweden), where T1 values were generated for 16 segments. Extracellular volumes (ECV) were calculated for the follow-up scan using:ECV=(1-hermatocrit)(ΔR1myocardium/ ΔR1blood)Segments were grouped according to their wall motion (WM) on the acute scan (normal/abnormal).",

author = "Trevor Ahearn and Baljit Jagpal and Donnie Cameron and Ng, {Bernice K.} and Caroline Scally and Higgins, {David M.} and John Horowitz and Frenneaux, {Michael P.} and Dawson, {Dana K.}",

note = "Funding Tenovus Scotland. Grant number G13/10. ",

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doi = "10.1186/1532-429X-17-S1-P259",

language = "English",

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TY - JOUR

T1 - Dynamic changes of the extracellular matrix after acute tako-tsubo cardiomyopathy

AU - Ahearn, Trevor

AU - Jagpal, Baljit

AU - Cameron, Donnie

AU - Ng, Bernice K.

AU - Scally, Caroline

AU - Higgins, David M.

AU - Horowitz, John

AU - Frenneaux, Michael P.

AU - Dawson, Dana K.

N1 - Funding Tenovus Scotland. Grant number G13/10.

PY - 2015/2/3

Y1 - 2015/2/3

N2 - BackgroundWe have recently demonstrated that cardiac energetic impairment and global myocardial edema persists for at least 4 months after an acute episode of Tako-tsubo cardiomyopathy (TTC). The aim of the current study was to evaluate the regional edema acutely and the status of the extracellular matrix at follow upMethodsEleven patients (10F, mean age 56±16yrs) with a clear diagnosis of ST-elevation TTC and emotional trigger were prospectively enrolled and underwent cardiac magnetic resonance acutely (day 0-3) and after 4 months on a Philips 3T Achieva scanner. Native 3-3-5 (MOLLI) T1 mapping was applied acutely, and both native and post-contrast T1 mapping were performed at 4 months follow-up. Eleven healthy controls underwent only native T1 mapping. T1 maps were: generated using in-house software - written in IDL (Exelis. Boulder CO, USA); quality controlled with chi-square maps; and imported into Segment (Medviso, Lund University, Sweden), where T1 values were generated for 16 segments. Extracellular volumes (ECV) were calculated for the follow-up scan using:ECV=(1-hermatocrit)(ΔR1myocardium/ ΔR1blood)Segments were grouped according to their wall motion (WM) on the acute scan (normal/abnormal).

AB - BackgroundWe have recently demonstrated that cardiac energetic impairment and global myocardial edema persists for at least 4 months after an acute episode of Tako-tsubo cardiomyopathy (TTC). The aim of the current study was to evaluate the regional edema acutely and the status of the extracellular matrix at follow upMethodsEleven patients (10F, mean age 56±16yrs) with a clear diagnosis of ST-elevation TTC and emotional trigger were prospectively enrolled and underwent cardiac magnetic resonance acutely (day 0-3) and after 4 months on a Philips 3T Achieva scanner. Native 3-3-5 (MOLLI) T1 mapping was applied acutely, and both native and post-contrast T1 mapping were performed at 4 months follow-up. Eleven healthy controls underwent only native T1 mapping. T1 maps were: generated using in-house software - written in IDL (Exelis. Boulder CO, USA); quality controlled with chi-square maps; and imported into Segment (Medviso, Lund University, Sweden), where T1 values were generated for 16 segments. Extracellular volumes (ECV) were calculated for the follow-up scan using:ECV=(1-hermatocrit)(ΔR1myocardium/ ΔR1blood)Segments were grouped according to their wall motion (WM) on the acute scan (normal/abnormal).

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U2 - 10.1186/1532-429X-17-S1-P259

DO - 10.1186/1532-429X-17-S1-P259

M3 - Abstract

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JO - Journal of Cardiovascular Magnetic Resonance

JF - Journal of Cardiovascular Magnetic Resonance

SN - 1097-6647

IS - Suppl. 1

M1 - P259

ER -

Dynamic changes of the extracellular matrix after acute tako-tsubo cardiomyopathy

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