Dynamic Fungal Cell Wall Architecture in Stress Adaptation and Immune Evasion

Alex Hopke; Alistair J P Brown; Rebecca A Hall; Robert T Wheeler

doi:10.1016/j.tim.2018.01.007

Dynamic Fungal Cell Wall Architecture in Stress Adaptation and Immune Evasion

Alex Hopke, Alistair J P Brown, Rebecca A Hall, Robert T Wheeler

Medical Sciences

Research output: Contribution to journal › Review article › peer-review

118 Citations (Scopus)

8 Downloads (Pure)

Abstract

Deadly infections from opportunistic fungi have risen in frequency, largely because of the at-risk immunocompromised population created by advances in modern medicine and the HIV/AIDS pandemic. This review focuses on dynamics of the fungal polysaccharide cell wall, which plays an outsized role in fungal pathogenesis and therapy because it acts as both an environmental barrier and as the major interface with the host immune system. Human fungal pathogens use architectural strategies to mask epitopes from the host and prevent immune surveillance, and recent work elucidates how biotic and abiotic stresses present during infection can either block or enhance masking. The signaling components implicated in regulating fungal immune recognition can teach us how cell wall dynamics are controlled, and represent potential targets for interventions designed to boost or dampen immunity.

Original language	English
Pages (from-to)	284-295
Number of pages	12
Journal	Trends in Microbiology
Volume	26
Issue number	4
Early online date	13 Feb 2018
DOIs	https://doi.org/10.1016/j.tim.2018.01.007
Publication status	Published - Apr 2018

Bibliographical note

The authors wish to acknowledge the many other recent studies on cell wall dynamics and immune response that we did not have space to adequately include. The work was supported by funding from the following sources: Burroughs Wellcome Fund (RTW). AJPB was funded by the UK Biotechnology and Biological Research Council (BB/K017365/1), the UK Medical Research Council (MR/M026663/1); the Wellcome Trust (097377) and by the MRC Centre for Medical Mycology and the University of Aberdeen (MR/M026663/1).

Keywords

Journal Article
Review
fungi
cell wall
glucan
innate immunity
evasion

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.tim.2018.01.007Licence: Unspecified

Accepted ManuscriptAccepted author manuscript, 3.18 MBLicence: Other

Cite this

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title = "Dynamic Fungal Cell Wall Architecture in Stress Adaptation and Immune Evasion",

abstract = "Deadly infections from opportunistic fungi have risen in frequency, largely because of the at-risk immunocompromised population created by advances in modern medicine and the HIV/AIDS pandemic. This review focuses on dynamics of the fungal polysaccharide cell wall, which plays an outsized role in fungal pathogenesis and therapy because it acts as both an environmental barrier and as the major interface with the host immune system. Human fungal pathogens use architectural strategies to mask epitopes from the host and prevent immune surveillance, and recent work elucidates how biotic and abiotic stresses present during infection can either block or enhance masking. The signaling components implicated in regulating fungal immune recognition can teach us how cell wall dynamics are controlled, and represent potential targets for interventions designed to boost or dampen immunity.",

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author = "Alex Hopke and Brown, {Alistair J P} and Hall, {Rebecca A} and Wheeler, {Robert T}",

note = "The authors wish to acknowledge the many other recent studies on cell wall dynamics and immune response that we did not have space to adequately include. The work was supported by funding from the following sources: Burroughs Wellcome Fund (RTW). AJPB was funded by the UK Biotechnology and Biological Research Council (BB/K017365/1), the UK Medical Research Council (MR/M026663/1); the Wellcome Trust (097377) and by the MRC Centre for Medical Mycology and the University of Aberdeen (MR/M026663/1).",

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AU - Hall, Rebecca A

AU - Wheeler, Robert T

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AB - Deadly infections from opportunistic fungi have risen in frequency, largely because of the at-risk immunocompromised population created by advances in modern medicine and the HIV/AIDS pandemic. This review focuses on dynamics of the fungal polysaccharide cell wall, which plays an outsized role in fungal pathogenesis and therapy because it acts as both an environmental barrier and as the major interface with the host immune system. Human fungal pathogens use architectural strategies to mask epitopes from the host and prevent immune surveillance, and recent work elucidates how biotic and abiotic stresses present during infection can either block or enhance masking. The signaling components implicated in regulating fungal immune recognition can teach us how cell wall dynamics are controlled, and represent potential targets for interventions designed to boost or dampen immunity.

KW - Journal Article

KW - Review

KW - fungi

KW - cell wall

KW - glucan

KW - innate immunity

KW - evasion

U2 - 10.1016/j.tim.2018.01.007

DO - 10.1016/j.tim.2018.01.007

M3 - Review article

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SN - 0966-842X

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JO - Trends in Microbiology

JF - Trends in Microbiology

IS - 4

ER -

Dynamic Fungal Cell Wall Architecture in Stress Adaptation and Immune Evasion

Abstract

Bibliographical note

Keywords

UN SDGs

Access to Document

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