Dynamic Fungal Cell Wall Architecture in Stress Adaptation and Immune Evasion

Alex Hopke, Alistair J P Brown, Rebecca A Hall, Robert T Wheeler

Research output: Contribution to journalReview article

22 Citations (Scopus)
5 Downloads (Pure)

Abstract

Deadly infections from opportunistic fungi have risen in frequency, largely because of the at-risk immunocompromised population created by advances in modern medicine and the HIV/AIDS pandemic. This review focuses on dynamics of the fungal polysaccharide cell wall, which plays an outsized role in fungal pathogenesis and therapy because it acts as both an environmental barrier and as the major interface with the host immune system. Human fungal pathogens use architectural strategies to mask epitopes from the host and prevent immune surveillance, and recent work elucidates how biotic and abiotic stresses present during infection can either block or enhance masking. The signaling components implicated in regulating fungal immune recognition can teach us how cell wall dynamics are controlled, and represent potential targets for interventions designed to boost or dampen immunity.

Original languageEnglish
Pages (from-to)284-295
Number of pages12
JournalTrends in Microbiology
Volume26
Issue number4
Early online date13 Feb 2018
DOIs
Publication statusPublished - Apr 2018

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Keywords

  • Journal Article
  • Review
  • fungi
  • cell wall
  • glucan
  • innate immunity
  • evasion

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