Dynamic magnetic resonance mammography of both breasts following local excision and radiotherapy for breast carcinoma

Alison Dorothy Murray, Thomas William Redpath, Gillian Needham, Fiona Jane Gilbert, J A Brookes, O Eremin

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

The purpose of this study was to evaluate a dynamic gadolinium-diethylene-triaminepentacetate (Gd-DTPA) enhanced magnetic resonance mammography (MRM) protocol. incorporating image subtraction and using a dedicated doable breast coil, in patients wit-h treated breast cancer. 36 patients who had undergone breast conserving surgery and radiotherapy, with clinical or mammographic suspicion of locally recurrent breast carcinoma, were examined. 3D rapid volume imaging of both breasts was performed before and repeated three times, at 1, 2 and 3 min, following Gd-DTPA enhancement. Image subtraction allowed identification of enhancing lesions and quantitative analysis of these was performed. Five patients had six lesions demonstrating rapid enhancement in the first minute, all of which were histologically confirmed recurrent or second primary tumours, Slower enhancement was seen in six benign lesions and diffuse enhancement was seen in one patient within 6 months of treatment. The dynamic protocol used allowed sufficient temporal resolution for distinguishing malignant from benign lesions al the site of previous surgery and ensured that both breasts were imaged in their entirety, thus enabling the diagnosis of multifocal and second primary tumours.

Original languageEnglish
Pages (from-to)594-600
Number of pages7
JournalBritish Journal of Radiology
Volume69
Issue number823
DOIs
Publication statusPublished - Jul 1996

Keywords

  • CANCER RECURRENCE
  • ENHANCED MRI
  • LESIONS
  • cancer recurrence
  • enhanced MRI
  • lesions

Cite this

Dynamic magnetic resonance mammography of both breasts following local excision and radiotherapy for breast carcinoma. / Murray, Alison Dorothy; Redpath, Thomas William; Needham, Gillian; Gilbert, Fiona Jane; Brookes, J A ; Eremin, O .

In: British Journal of Radiology, Vol. 69, No. 823, 07.1996, p. 594-600.

Research output: Contribution to journalArticle

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abstract = "The purpose of this study was to evaluate a dynamic gadolinium-diethylene-triaminepentacetate (Gd-DTPA) enhanced magnetic resonance mammography (MRM) protocol. incorporating image subtraction and using a dedicated doable breast coil, in patients wit-h treated breast cancer. 36 patients who had undergone breast conserving surgery and radiotherapy, with clinical or mammographic suspicion of locally recurrent breast carcinoma, were examined. 3D rapid volume imaging of both breasts was performed before and repeated three times, at 1, 2 and 3 min, following Gd-DTPA enhancement. Image subtraction allowed identification of enhancing lesions and quantitative analysis of these was performed. Five patients had six lesions demonstrating rapid enhancement in the first minute, all of which were histologically confirmed recurrent or second primary tumours, Slower enhancement was seen in six benign lesions and diffuse enhancement was seen in one patient within 6 months of treatment. The dynamic protocol used allowed sufficient temporal resolution for distinguishing malignant from benign lesions al the site of previous surgery and ensured that both breasts were imaged in their entirety, thus enabling the diagnosis of multifocal and second primary tumours.",
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