Dynamic synchronisation of central oscillators in essential tremor

B Hellwig, B Schelter, B Guschlbauer, J Timmer, C H Lucking

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

Objective: Coherence analysis of electromyography (EMG) signals in essential tremor (ET) suggests that tremor in the right and left arm is induced by independent central oscillators. The sensorimotor cortex seems to be part of the tremor-generating neuronal network in ET. Here, we investigated using electroencephalography (EEG) whether the independence of central oscillators in ET is supported by the analysis of cortical activity.

Methods: In 8 patients with ET, bilateral hand tremor was activated by wrist extension. EMGs from the wrist flexors and extensors were recorded simultaneously with an EEG. EEG-EMG coherence was estimated for 74 epochs of 60 s duration.

Results: In 42.6% of the cases, EEG-EMG coherence at the tremor frequency existed only with the contralateral sensorimotor cortex. However, 21.6% of the tremor-EMGs were coherent with EEG activity over both the contralateral and ipsilateral sensorimotor cortex. Bilateral and exclusively contralateral EEG-EMG coherence could alternate within the same recording. Bilateral EEG-EMG coherence was associated with increased right-left EEG-EEG coherence, increased right-left EMG-EMG coherence as well as with increased tremor strength.

Conclusions: In ET, central oscillators in the right and left brain are not entirely independent of each other. They may dynamically synchronise, presumably by interhemispheric coupling via the corpus callosum. (C) 2003 International Federation of Clinical Neurophysiology. Published by Elsevier Science Ireland Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)1462-1467
Number of pages6
JournalClinical Neurophysiology
Volume114
Issue number8
DOIs
Publication statusPublished - Aug 2003

Keywords

  • essential tremor
  • EEG-EMG coherence
  • motor cortex
  • oscillation
  • interhemispheric interaction

Cite this

Dynamic synchronisation of central oscillators in essential tremor. / Hellwig, B ; Schelter, B ; Guschlbauer, B ; Timmer, J ; Lucking, C H .

In: Clinical Neurophysiology, Vol. 114, No. 8, 08.2003, p. 1462-1467.

Research output: Contribution to journalArticle

Hellwig, B ; Schelter, B ; Guschlbauer, B ; Timmer, J ; Lucking, C H . / Dynamic synchronisation of central oscillators in essential tremor. In: Clinical Neurophysiology. 2003 ; Vol. 114, No. 8. pp. 1462-1467.
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