Dynamics of nasopharyngeal bacterial colonisation in HIV-exposed young infants in Tanzania

G. D. Kinabo, A. van der Ven, L. J. Msuya, A. M. Shayo, W. Schimana, A. Ndaro, H. A. G. H. van Asten, W. M. V. Dolmans, A Warris, P. W. M. Hermans

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Abstract

OBJECTIVES: To estimate the prevalence of nasopharyngeal bacterial colonisation (NPBC) patterns in young Tanzanian HIV-exposed infants and to analyse the influence of maternal NPBC and of the infant's HIV status on the NPBC pattern.

METHODS: Longitudinal cohort study of neonates born to HIV-infected mothers visiting Kilimanjaro Christian Medical Centre, Tanzania, between 2005 and 2009. Demographic and clinical data and nasopharyngeal bacterial cultures were obtained at the age of 6 weeks, 3 and 6 months, and at one time point, a paired mother-infant nasopharyngeal swab was taken.

RESULTS: Four hundred and twenty-two swabs were taken from 338 eligible infants. At 6 weeks of age, colonisation rates were 66% for Staphylococcus aureus, 56% for Streptococcus pneumoniae, 50% for Moraxella catarrhalis and 14% for Haemophilus influenzae. Colonisation with S. aureus diminished over time and was more common in HIV-infected infants. S. pneumoniae and H. influenzae colonisation rose over time and was more prevalent in HIV-uninfected children. Co-colonisation of S. pneumoniae with H. influenzae or M. catarrhalis was mostly noticed in HIV-infected infants. S. pneumoniae and M.catarrhalis colonisation of the mother was a risk factor for colonisation in HIV-uninfected infants, while maternal S. aureus colonisation was a risk factor for colonisation in HIV-infected infants. Among the 104 S. pneumoniae isolates, 19F was most prevalent, and 57 (55%) displayed capsular serotypes represented in the 13-valent pneumococcal conjugate vaccine.

CONCLUSIONS: NPBC was common in Tanzanian HIV-exposed infants. The significant prevalence of pneumococcal vaccine serotypes colonising this paediatric population justifies the use of the 13-valent pneumococcal vaccine to reduce the burden of pneumococcal invasive disease.

Original languageEnglish
Pages (from-to)286-295
Number of pages10
JournalTropical Medicine and International Health
Volume18
Issue number3
Early online date16 Jan 2013
DOIs
Publication statusPublished - Mar 2013

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Tanzania
HIV
Streptococcus pneumoniae
Mothers
Haemophilus influenzae
Staphylococcus aureus
Moraxella (Branhamella) catarrhalis
Conjugate Vaccines
Pneumococcal Vaccines
Longitudinal Studies
Cohort Studies
Demography
Newborn Infant
Pediatrics

Keywords

  • Streptococcus pneumoniae
  • Staphylococcus aureus
  • Haemophilus influenzae
  • Moraxella catarrhalis
  • nasopharyngeal colonisation
  • children
  • HIV
  • Tanzania

Cite this

Kinabo, G. D., van der Ven, A., Msuya, L. J., Shayo, A. M., Schimana, W., Ndaro, A., ... Hermans, P. W. M. (2013). Dynamics of nasopharyngeal bacterial colonisation in HIV-exposed young infants in Tanzania. Tropical Medicine and International Health, 18(3), 286-295. https://doi.org/10.1111/tmi.12057

Dynamics of nasopharyngeal bacterial colonisation in HIV-exposed young infants in Tanzania. / Kinabo, G. D.; van der Ven, A.; Msuya, L. J.; Shayo, A. M.; Schimana, W.; Ndaro, A.; van Asten, H. A. G. H.; Dolmans, W. M. V.; Warris, A; Hermans, P. W. M.

In: Tropical Medicine and International Health, Vol. 18, No. 3, 03.2013, p. 286-295.

Research output: Contribution to journalArticle

Kinabo, GD, van der Ven, A, Msuya, LJ, Shayo, AM, Schimana, W, Ndaro, A, van Asten, HAGH, Dolmans, WMV, Warris, A & Hermans, PWM 2013, 'Dynamics of nasopharyngeal bacterial colonisation in HIV-exposed young infants in Tanzania', Tropical Medicine and International Health, vol. 18, no. 3, pp. 286-295. https://doi.org/10.1111/tmi.12057
Kinabo, G. D. ; van der Ven, A. ; Msuya, L. J. ; Shayo, A. M. ; Schimana, W. ; Ndaro, A. ; van Asten, H. A. G. H. ; Dolmans, W. M. V. ; Warris, A ; Hermans, P. W. M. / Dynamics of nasopharyngeal bacterial colonisation in HIV-exposed young infants in Tanzania. In: Tropical Medicine and International Health. 2013 ; Vol. 18, No. 3. pp. 286-295.
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abstract = "OBJECTIVES: To estimate the prevalence of nasopharyngeal bacterial colonisation (NPBC) patterns in young Tanzanian HIV-exposed infants and to analyse the influence of maternal NPBC and of the infant's HIV status on the NPBC pattern.METHODS: Longitudinal cohort study of neonates born to HIV-infected mothers visiting Kilimanjaro Christian Medical Centre, Tanzania, between 2005 and 2009. Demographic and clinical data and nasopharyngeal bacterial cultures were obtained at the age of 6 weeks, 3 and 6 months, and at one time point, a paired mother-infant nasopharyngeal swab was taken.RESULTS: Four hundred and twenty-two swabs were taken from 338 eligible infants. At 6 weeks of age, colonisation rates were 66{\%} for Staphylococcus aureus, 56{\%} for Streptococcus pneumoniae, 50{\%} for Moraxella catarrhalis and 14{\%} for Haemophilus influenzae. Colonisation with S. aureus diminished over time and was more common in HIV-infected infants. S. pneumoniae and H. influenzae colonisation rose over time and was more prevalent in HIV-uninfected children. Co-colonisation of S. pneumoniae with H. influenzae or M. catarrhalis was mostly noticed in HIV-infected infants. S. pneumoniae and M.catarrhalis colonisation of the mother was a risk factor for colonisation in HIV-uninfected infants, while maternal S. aureus colonisation was a risk factor for colonisation in HIV-infected infants. Among the 104 S. pneumoniae isolates, 19F was most prevalent, and 57 (55{\%}) displayed capsular serotypes represented in the 13-valent pneumococcal conjugate vaccine.CONCLUSIONS: NPBC was common in Tanzanian HIV-exposed infants. The significant prevalence of pneumococcal vaccine serotypes colonising this paediatric population justifies the use of the 13-valent pneumococcal vaccine to reduce the burden of pneumococcal invasive disease.",
keywords = "Streptococcus pneumoniae, Staphylococcus aureus, Haemophilus influenzae, Moraxella catarrhalis, nasopharyngeal colonisation, children, HIV, Tanzania",
author = "Kinabo, {G. D.} and {van der Ven}, A. and Msuya, {L. J.} and Shayo, {A. M.} and W. Schimana and A. Ndaro and {van Asten}, {H. A. G. H.} and Dolmans, {W. M. V.} and A Warris and Hermans, {P. W. M.}",
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TY - JOUR

T1 - Dynamics of nasopharyngeal bacterial colonisation in HIV-exposed young infants in Tanzania

AU - Kinabo, G. D.

AU - van der Ven, A.

AU - Msuya, L. J.

AU - Shayo, A. M.

AU - Schimana, W.

AU - Ndaro, A.

AU - van Asten, H. A. G. H.

AU - Dolmans, W. M. V.

AU - Warris, A

AU - Hermans, P. W. M.

N1 - Acknowledgement We thank Mrs. C. Gaast-de Jongh for performing the serotyping of the S. pneumoniae isolates.

PY - 2013/3

Y1 - 2013/3

N2 - OBJECTIVES: To estimate the prevalence of nasopharyngeal bacterial colonisation (NPBC) patterns in young Tanzanian HIV-exposed infants and to analyse the influence of maternal NPBC and of the infant's HIV status on the NPBC pattern.METHODS: Longitudinal cohort study of neonates born to HIV-infected mothers visiting Kilimanjaro Christian Medical Centre, Tanzania, between 2005 and 2009. Demographic and clinical data and nasopharyngeal bacterial cultures were obtained at the age of 6 weeks, 3 and 6 months, and at one time point, a paired mother-infant nasopharyngeal swab was taken.RESULTS: Four hundred and twenty-two swabs were taken from 338 eligible infants. At 6 weeks of age, colonisation rates were 66% for Staphylococcus aureus, 56% for Streptococcus pneumoniae, 50% for Moraxella catarrhalis and 14% for Haemophilus influenzae. Colonisation with S. aureus diminished over time and was more common in HIV-infected infants. S. pneumoniae and H. influenzae colonisation rose over time and was more prevalent in HIV-uninfected children. Co-colonisation of S. pneumoniae with H. influenzae or M. catarrhalis was mostly noticed in HIV-infected infants. S. pneumoniae and M.catarrhalis colonisation of the mother was a risk factor for colonisation in HIV-uninfected infants, while maternal S. aureus colonisation was a risk factor for colonisation in HIV-infected infants. Among the 104 S. pneumoniae isolates, 19F was most prevalent, and 57 (55%) displayed capsular serotypes represented in the 13-valent pneumococcal conjugate vaccine.CONCLUSIONS: NPBC was common in Tanzanian HIV-exposed infants. The significant prevalence of pneumococcal vaccine serotypes colonising this paediatric population justifies the use of the 13-valent pneumococcal vaccine to reduce the burden of pneumococcal invasive disease.

AB - OBJECTIVES: To estimate the prevalence of nasopharyngeal bacterial colonisation (NPBC) patterns in young Tanzanian HIV-exposed infants and to analyse the influence of maternal NPBC and of the infant's HIV status on the NPBC pattern.METHODS: Longitudinal cohort study of neonates born to HIV-infected mothers visiting Kilimanjaro Christian Medical Centre, Tanzania, between 2005 and 2009. Demographic and clinical data and nasopharyngeal bacterial cultures were obtained at the age of 6 weeks, 3 and 6 months, and at one time point, a paired mother-infant nasopharyngeal swab was taken.RESULTS: Four hundred and twenty-two swabs were taken from 338 eligible infants. At 6 weeks of age, colonisation rates were 66% for Staphylococcus aureus, 56% for Streptococcus pneumoniae, 50% for Moraxella catarrhalis and 14% for Haemophilus influenzae. Colonisation with S. aureus diminished over time and was more common in HIV-infected infants. S. pneumoniae and H. influenzae colonisation rose over time and was more prevalent in HIV-uninfected children. Co-colonisation of S. pneumoniae with H. influenzae or M. catarrhalis was mostly noticed in HIV-infected infants. S. pneumoniae and M.catarrhalis colonisation of the mother was a risk factor for colonisation in HIV-uninfected infants, while maternal S. aureus colonisation was a risk factor for colonisation in HIV-infected infants. Among the 104 S. pneumoniae isolates, 19F was most prevalent, and 57 (55%) displayed capsular serotypes represented in the 13-valent pneumococcal conjugate vaccine.CONCLUSIONS: NPBC was common in Tanzanian HIV-exposed infants. The significant prevalence of pneumococcal vaccine serotypes colonising this paediatric population justifies the use of the 13-valent pneumococcal vaccine to reduce the burden of pneumococcal invasive disease.

KW - Streptococcus pneumoniae

KW - Staphylococcus aureus

KW - Haemophilus influenzae

KW - Moraxella catarrhalis

KW - nasopharyngeal colonisation

KW - children

KW - HIV

KW - Tanzania

U2 - 10.1111/tmi.12057

DO - 10.1111/tmi.12057

M3 - Article

VL - 18

SP - 286

EP - 295

JO - Tropical Medicine and International Health

JF - Tropical Medicine and International Health

SN - 1360-2276

IS - 3

ER -