Dysregulated metabolism contributes to oncogenesis

Matthew D Hirschey, Ralph J DeBerardinis, Anna Mae E Diehl, Janice E Drew, Christian Frezza, Michelle F Green, Lee W Jones, Young H Ko, Anne Le, Michael A Lea, Jason W Locasale, Valter D Longo, Costas A Lyssiotis, Eoin McDonnell, Mahya Mehrmohamadi, Gregory Michelotti, Vinayak Muralidhar, Michael P Murphy, Peter L Pedersen, Brad Poore & 6 others Lizzia Raffaghello, Jeffrey C Rathmell, Sharanya Sivanand, Matthew G Vander Heiden, Kathryn E Wellen, Target Validation Team

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Abstract

Cancer is a disease characterized by unrestrained cellular proliferation. In order to sustain growth, cancer cells undergo a complex metabolic rearrangement characterized by changes in metabolic pathways involved in energy production and biosynthetic processes. The relevance of the metabolic transformation of cancer cells has been recently included in the updated version of the review "Hallmarks of Cancer", where dysregulation of cellular metabolism was included as an emerging hallmark. While several lines of evidence suggest that metabolic rewiring is orchestrated by the concerted action of oncogenes and tumor suppressor genes, in some circumstances altered metabolism can play a primary role in oncogenesis. Recently, mutations of cytosolic and mitochondrial enzymes involved in key metabolic pathways have been associated with hereditary and sporadic forms of cancer. Together, these results demonstrate that aberrant metabolism, once seen just as an epiphenomenon of oncogenic reprogramming, plays a key role in oncogenesis with the power to control both genetic and epigenetic events in cells. In this review, we discuss the relationship between metabolism and cancer, as part of a larger effort to identify a broad-spectrum of therapeutic approaches. We focus on major alterations in nutrient metabolism and the emerging link between metabolism and epigenetics. Finally, we discuss potential strategies to manipulate metabolism in cancer and tradeoffs that should be considered. More research on the suite of metabolic alterations in cancer holds the potential to discover novel approaches to treat it.

Original languageEnglish
Pages (from-to)S129-150
Number of pages22
JournalSeminars in cancer biology
Volume35
Issue numberSuppl.
Early online date8 Oct 2015
DOIs
Publication statusPublished - Dec 2015

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Carcinogenesis
Neoplasms
Metabolic Networks and Pathways
Epigenomics
Tumor Suppressor Genes
Oncogenes
Cell Proliferation
Food
Mutation
Enzymes
Growth
Research

Keywords

  • Cancer metabolism
  • Mitochondria
  • Warburg
  • Host metabolism

Cite this

Hirschey, M. D., DeBerardinis, R. J., Diehl, A. M. E., Drew, J. E., Frezza, C., Green, M. F., ... Target Validation Team (2015). Dysregulated metabolism contributes to oncogenesis. Seminars in cancer biology, 35(Suppl.), S129-150. https://doi.org/10.1016/j.semcancer.2015.10.002

Dysregulated metabolism contributes to oncogenesis. / Hirschey, Matthew D; DeBerardinis, Ralph J; Diehl, Anna Mae E; Drew, Janice E; Frezza, Christian; Green, Michelle F; Jones, Lee W; Ko, Young H; Le, Anne; Lea, Michael A; Locasale, Jason W; Longo, Valter D; Lyssiotis, Costas A; McDonnell, Eoin; Mehrmohamadi, Mahya; Michelotti, Gregory; Muralidhar, Vinayak; Murphy, Michael P; Pedersen, Peter L; Poore, Brad; Raffaghello, Lizzia; Rathmell, Jeffrey C; Sivanand, Sharanya; Vander Heiden, Matthew G; Wellen, Kathryn E; Target Validation Team.

In: Seminars in cancer biology, Vol. 35, No. Suppl., 12.2015, p. S129-150.

Research output: Contribution to journalArticle

Hirschey, MD, DeBerardinis, RJ, Diehl, AME, Drew, JE, Frezza, C, Green, MF, Jones, LW, Ko, YH, Le, A, Lea, MA, Locasale, JW, Longo, VD, Lyssiotis, CA, McDonnell, E, Mehrmohamadi, M, Michelotti, G, Muralidhar, V, Murphy, MP, Pedersen, PL, Poore, B, Raffaghello, L, Rathmell, JC, Sivanand, S, Vander Heiden, MG, Wellen, KE & Target Validation Team 2015, 'Dysregulated metabolism contributes to oncogenesis', Seminars in cancer biology, vol. 35, no. Suppl., pp. S129-150. https://doi.org/10.1016/j.semcancer.2015.10.002
Hirschey MD, DeBerardinis RJ, Diehl AME, Drew JE, Frezza C, Green MF et al. Dysregulated metabolism contributes to oncogenesis. Seminars in cancer biology. 2015 Dec;35(Suppl.):S129-150. https://doi.org/10.1016/j.semcancer.2015.10.002
Hirschey, Matthew D ; DeBerardinis, Ralph J ; Diehl, Anna Mae E ; Drew, Janice E ; Frezza, Christian ; Green, Michelle F ; Jones, Lee W ; Ko, Young H ; Le, Anne ; Lea, Michael A ; Locasale, Jason W ; Longo, Valter D ; Lyssiotis, Costas A ; McDonnell, Eoin ; Mehrmohamadi, Mahya ; Michelotti, Gregory ; Muralidhar, Vinayak ; Murphy, Michael P ; Pedersen, Peter L ; Poore, Brad ; Raffaghello, Lizzia ; Rathmell, Jeffrey C ; Sivanand, Sharanya ; Vander Heiden, Matthew G ; Wellen, Kathryn E ; Target Validation Team. / Dysregulated metabolism contributes to oncogenesis. In: Seminars in cancer biology. 2015 ; Vol. 35, No. Suppl. pp. S129-150.
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AU - Ko, Young H

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AU - McDonnell, Eoin

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AU - Michelotti, Gregory

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AU - Murphy, Michael P

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AU - Poore, Brad

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AU - Rathmell, Jeffrey C

AU - Sivanand, Sharanya

AU - Vander Heiden, Matthew G

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N2 - Cancer is a disease characterized by unrestrained cellular proliferation. In order to sustain growth, cancer cells undergo a complex metabolic rearrangement characterized by changes in metabolic pathways involved in energy production and biosynthetic processes. The relevance of the metabolic transformation of cancer cells has been recently included in the updated version of the review "Hallmarks of Cancer", where dysregulation of cellular metabolism was included as an emerging hallmark. While several lines of evidence suggest that metabolic rewiring is orchestrated by the concerted action of oncogenes and tumor suppressor genes, in some circumstances altered metabolism can play a primary role in oncogenesis. Recently, mutations of cytosolic and mitochondrial enzymes involved in key metabolic pathways have been associated with hereditary and sporadic forms of cancer. Together, these results demonstrate that aberrant metabolism, once seen just as an epiphenomenon of oncogenic reprogramming, plays a key role in oncogenesis with the power to control both genetic and epigenetic events in cells. In this review, we discuss the relationship between metabolism and cancer, as part of a larger effort to identify a broad-spectrum of therapeutic approaches. We focus on major alterations in nutrient metabolism and the emerging link between metabolism and epigenetics. Finally, we discuss potential strategies to manipulate metabolism in cancer and tradeoffs that should be considered. More research on the suite of metabolic alterations in cancer holds the potential to discover novel approaches to treat it.

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