Abstract
Original language | English |
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Pages (from-to) | 10-18 |
Number of pages | 9 |
Journal | Brain Research |
Volume | 1477 |
DOIs | |
Publication status | Published - 5 Oct 2012 |
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Keywords
- neuropeptide Y
- orexin
- POMC
- accurate and paraventricular nuclei
- dietary composition
Cite this
Early and persistent up-regulation of hypothalamic orexigenic peptides in rat offspring born to dams fed a high-carbohydrate supplement during gestation. / Beck, Bernard; Richy, Sébastien; Archer, Zoe A; Mercer, Julian G.
In: Brain Research, Vol. 1477, 05.10.2012, p. 10-18.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Early and persistent up-regulation of hypothalamic orexigenic peptides in rat offspring born to dams fed a high-carbohydrate supplement during gestation
AU - Beck, Bernard
AU - Richy, Sébastien
AU - Archer, Zoe A
AU - Mercer, Julian G
N1 - Copyright © 2012 Elsevier B.V. All rights reserved.
PY - 2012/10/5
Y1 - 2012/10/5
N2 - Maternal diet ingested during gestation can profoundly alter production and action of hypothalamic neuropeptides involved in feeding and body weight regulation. In this study, we set out to simulate, in a rat model, modifications to feeding habit often observed in pregnant women. Gestating dams were fed a restricted normal diet with the opportunity to complete their energy requirements with either a high-fat (HF) or a high-carbohydrate (HC) diet. Growth and hypothalamic feeding peptides were measured in the offspring at 3 (weaning) and 20 weeks of age. At weaning, body weight was lower in HC pups than in HF pups or control (Ca) pups born to dams fed control diet ad libitum. Expression of neuropeptide Y (NPY) and AgRP mRNA in the arcuate nucleus were increased in HC pups vs Ca and HF pups. By 20 weeks of age, body weight differentials had disappeared, and there was no differences in NPY and AgRP gene expression, although POMC expression was lower in HC rats than in HF rats. NPY and orexin peptide concentrations in the paraventricular nucleus at this age were higher in HC rats than in Ca and HF rats. In HC rats, there was also a greater positive gradient of peptide concentration between the zone of release and the zone of synthesis for NPY and orexin. The early up-regulation of orexigenic peptides in HC rats may be a compensatory adjustment to low body weight. This persisting overactive orexigenic drive might have deleterious metabolic effects in an obesogenic environment at adulthood.
AB - Maternal diet ingested during gestation can profoundly alter production and action of hypothalamic neuropeptides involved in feeding and body weight regulation. In this study, we set out to simulate, in a rat model, modifications to feeding habit often observed in pregnant women. Gestating dams were fed a restricted normal diet with the opportunity to complete their energy requirements with either a high-fat (HF) or a high-carbohydrate (HC) diet. Growth and hypothalamic feeding peptides were measured in the offspring at 3 (weaning) and 20 weeks of age. At weaning, body weight was lower in HC pups than in HF pups or control (Ca) pups born to dams fed control diet ad libitum. Expression of neuropeptide Y (NPY) and AgRP mRNA in the arcuate nucleus were increased in HC pups vs Ca and HF pups. By 20 weeks of age, body weight differentials had disappeared, and there was no differences in NPY and AgRP gene expression, although POMC expression was lower in HC rats than in HF rats. NPY and orexin peptide concentrations in the paraventricular nucleus at this age were higher in HC rats than in Ca and HF rats. In HC rats, there was also a greater positive gradient of peptide concentration between the zone of release and the zone of synthesis for NPY and orexin. The early up-regulation of orexigenic peptides in HC rats may be a compensatory adjustment to low body weight. This persisting overactive orexigenic drive might have deleterious metabolic effects in an obesogenic environment at adulthood.
KW - neuropeptide Y
KW - orexin
KW - POMC
KW - accurate and paraventricular nuclei
KW - dietary composition
U2 - 10.1016/j.brainres.2012.08.021
DO - 10.1016/j.brainres.2012.08.021
M3 - Article
VL - 1477
SP - 10
EP - 18
JO - Brain Research
JF - Brain Research
SN - 0006-8993
ER -