Early detection of oral cancer - Is dielectrophoresis the answer?

Lionel Broche, Navneet Bhadal, Mark P Lewis, Stephen Porter, Michael P. Hughes, Fatima H. Labeed

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

The early detection of oral squamous cell carcinoma by non-invasive methods has the potential to hasten diagnosis and thus lessen the morbidity associated with tumour therapy. Dielectrophoresis (DEP) can non-invasively determine electrophysiological parameters such as conductivity and permittivity of cellular cytoplasm and membrane. The present study demonstrates that DEP can be utilised to characterise H357 and UP cells and reveals that there are significant differences in these parameters between malignant and more normal epithelial cell lines. The present results suggest that DEP has potential for the early detection of cancerous from non-cancerous cells in a clinical setting.
Original languageEnglish
Pages (from-to)199-203
Number of pages5
JournalOral Oncology
Volume43
Issue number2
Early online date20 Sep 2006
DOIs
Publication statusPublished - Feb 2007

Keywords

  • Dielectrophoresis
  • Characterization
  • Carcinoma
  • Keratinocyte
  • Membrane
  • Conductivity
  • Separation

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    Broche, L., Bhadal, N., Lewis, M. P., Porter, S., Hughes, M. P., & Labeed, F. H. (2007). Early detection of oral cancer - Is dielectrophoresis the answer? Oral Oncology, 43(2), 199-203. https://doi.org/10.1016/j.oraloncology.2006.02.012