Early diffusion weighted magnetic resonance imaging can predict survival in women with locally advanced cancer of the cervix treated with combined chemo-radiation

Gbolahan Somoye, Vanessa Harry, Scott I. Semple, George Plataniotis, Neil William Scott, Fiona Gilbert, David Parkin

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

Objectives
To assess the predictive value of diffusion weighted imaging (DWI) for survival in women treated for advanced cancer of the cervix with concurrent chemo-radiotherapy.

Methods
Twenty women treated for advanced cancer of the cervix were recruited and followed up for a median of 26 (range <1 to 43) months. They each had DWI performed before treatment, 2 weeks after beginning therapy (midtreatment) and at the end of treatment. Apparent diffusion coefficient (ADC) values were calculated from regions of interest (ROI). All participants were reviewed for follow-up data. ADC values were compared with mortality status (Mann–Whitney test). Time to progression and overall survival were assessed (Kaplan–Meier survival graphs).

Results
There were 14 survivors. The median midtreatment ADC was statistically significantly higher in those alive compared to the non-survivors, 1.55 and 1.36 (×10-3/mm2/s), respectively, P¿=¿0.02. The median change in ADC 14 days after treatment commencement was significantly higher in the alive group compared to non-survivors, 0.28 and 0.14 (×10-3/mm2/s), respectively, P¿=¿0.02. There was no evidence of a difference between survivors and non-survivors for pretreatment baseline or post-therapy ADC values.

Conclusion
Functional DWI early in the treatment of advanced cancer of the cervix may provide useful information in predicting survival.

Key Points
• Diffusion weighted magnetic resonance imaging (DWI) is increasingly used in cervical cancer.
• Functional DWI early in treatment of cervical cancer may help predict survival.
• DWI may help clinicians to tailor or individualise treatment appropriately.
• This may limit toxicity from ineffective treatment and allow early alternative therapy.
Original languageEnglish
Pages (from-to)2319-2327
Number of pages9
JournalEuropean Radiology
Volume22
Issue number11
Early online date1 Jun 2012
DOIs
Publication statusPublished - Nov 2012

Keywords

  • cervical cancer
  • diffusion weighted magnetic resonance imaging (DWI)
  • apparent diffusion coefficient
  • survival
  • chemo-radiotherapy

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