Early identification of atopy in the prediction of persistent asthma in children

Peter D. Sly; Attilio L. Boner; Bengt Bjorksten; Andy Bush; Adnan Custovic; Philippe A. Eigenmann; James E. Gern; Jorrit Gerritsen; Eckard Hamelmann; Peter J. Helms; Robert F. Lemanske; Fernando Martinez; Soren Pedersen; Harald Renz; Hugh Sampson; Erika von Mutius; Ulrich Wahn; Patrick G. Holt

doi:10.1016/S0140-6736(08)61451-8

Early identification of atopy in the prediction of persistent asthma in children

Peter D. Sly, Attilio L. Boner, Bengt Bjorksten, Andy Bush, Adnan Custovic, Philippe A. Eigenmann, James E. Gern, Jorrit Gerritsen, Eckard Hamelmann, Peter J. Helms, Robert F. Lemanske, Fernando Martinez, Soren Pedersen, Harald Renz, Hugh Sampson, Erika von Mutius, Ulrich Wahn, Patrick G. Holt

Applied Health Sciences

Research output: Contribution to journal › Literature review

287 Citations (Scopus)

Abstract

The long-term solution to the asthma epidemic is thought to be prevention, and not treatment of established disease. Atopic asthma arises from gene-environment interactions, which mainly take place during a short period in prenatal and postnatal development. These interactions are not completely understood, and hence primary prevention remains an elusive goal. We argue that primary-care physicians, paediatricians, and specialists lack knowledge of the role of atopy in early life in the development of persistent asthma in children. In this review, we discuss how early identification of children at high risk is feasible on the basis of available technology and important for potential benefits to the children. Identification of an asthmatic child's atopic status in early life has practical clinical and prognostic implications, and sets the basis for future preventative strategies.

Original language	English
Pages (from-to)	1100-1106
Number of pages	7
Journal	The Lancet
Volume	372
Issue number	9643
DOIs	https://doi.org/10.1016/S0140-6736(08)61451-8
Publication status	Published - Sep 2008

Keywords

respiratory syncytial virus
childhood asthma
birth cohort
early-life
postnatal maturation
preschool-children
airway epithelium
risk-factors
follow-up
allergen sensitization

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Sly, P. D., Boner, A. L., Bjorksten, B., Bush, A., Custovic, A., Eigenmann, P. A., Gern, J. E., Gerritsen, J., Hamelmann, E., Helms, P. J., Lemanske, R. F., Martinez, F., Pedersen, S., Renz, H., Sampson, H., von Mutius, E., Wahn, U., & Holt, P. G. (2008). Early identification of atopy in the prediction of persistent asthma in children. The Lancet, 372(9643), 1100-1106. https://doi.org/10.1016/S0140-6736(08)61451-8

Sly, PD, Boner, AL, Bjorksten, B, Bush, A, Custovic, A, Eigenmann, PA, Gern, JE, Gerritsen, J, Hamelmann, E, Helms, PJ, Lemanske, RF, Martinez, F, Pedersen, S, Renz, H, Sampson, H, von Mutius, E, Wahn, U & Holt, PG 2008, 'Early identification of atopy in the prediction of persistent asthma in children', The Lancet, vol. 372, no. 9643, pp. 1100-1106. https://doi.org/10.1016/S0140-6736(08)61451-8

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title = "Early identification of atopy in the prediction of persistent asthma in children",

abstract = "The long-term solution to the asthma epidemic is thought to be prevention, and not treatment of established disease. Atopic asthma arises from gene-environment interactions, which mainly take place during a short period in prenatal and postnatal development. These interactions are not completely understood, and hence primary prevention remains an elusive goal. We argue that primary-care physicians, paediatricians, and specialists lack knowledge of the role of atopy in early life in the development of persistent asthma in children. In this review, we discuss how early identification of children at high risk is feasible on the basis of available technology and important for potential benefits to the children. Identification of an asthmatic child's atopic status in early life has practical clinical and prognostic implications, and sets the basis for future preventative strategies.",

keywords = "respiratory syncytial virus, childhood asthma , birth cohort, early-life, postnatal maturation, preschool-children, airway epithelium, risk-factors, follow-up, allergen sensitization",

author = "Sly, {Peter D.} and Boner, {Attilio L.} and Bengt Bjorksten and Andy Bush and Adnan Custovic and Eigenmann, {Philippe A.} and Gern, {James E.} and Jorrit Gerritsen and Eckard Hamelmann and Helms, {Peter J.} and Lemanske, {Robert F.} and Fernando Martinez and Soren Pedersen and Harald Renz and Hugh Sampson and {von Mutius}, Erika and Ulrich Wahn and Holt, {Patrick G.}",

year = "2008",

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doi = "10.1016/S0140-6736(08)61451-8",

language = "English",

volume = "372",

pages = "1100--1106",

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TY - JOUR

T1 - Early identification of atopy in the prediction of persistent asthma in children

AU - Sly, Peter D.

AU - Boner, Attilio L.

AU - Bjorksten, Bengt

AU - Bush, Andy

AU - Custovic, Adnan

AU - Eigenmann, Philippe A.

AU - Gern, James E.

AU - Gerritsen, Jorrit

AU - Hamelmann, Eckard

AU - Helms, Peter J.

AU - Lemanske, Robert F.

AU - Martinez, Fernando

AU - Pedersen, Soren

AU - Renz, Harald

AU - Sampson, Hugh

AU - von Mutius, Erika

AU - Wahn, Ulrich

AU - Holt, Patrick G.

PY - 2008/9

Y1 - 2008/9

N2 - The long-term solution to the asthma epidemic is thought to be prevention, and not treatment of established disease. Atopic asthma arises from gene-environment interactions, which mainly take place during a short period in prenatal and postnatal development. These interactions are not completely understood, and hence primary prevention remains an elusive goal. We argue that primary-care physicians, paediatricians, and specialists lack knowledge of the role of atopy in early life in the development of persistent asthma in children. In this review, we discuss how early identification of children at high risk is feasible on the basis of available technology and important for potential benefits to the children. Identification of an asthmatic child's atopic status in early life has practical clinical and prognostic implications, and sets the basis for future preventative strategies.

AB - The long-term solution to the asthma epidemic is thought to be prevention, and not treatment of established disease. Atopic asthma arises from gene-environment interactions, which mainly take place during a short period in prenatal and postnatal development. These interactions are not completely understood, and hence primary prevention remains an elusive goal. We argue that primary-care physicians, paediatricians, and specialists lack knowledge of the role of atopy in early life in the development of persistent asthma in children. In this review, we discuss how early identification of children at high risk is feasible on the basis of available technology and important for potential benefits to the children. Identification of an asthmatic child's atopic status in early life has practical clinical and prognostic implications, and sets the basis for future preventative strategies.

KW - respiratory syncytial virus

KW - childhood asthma

KW - birth cohort

KW - early-life

KW - postnatal maturation

KW - preschool-children

KW - airway epithelium

KW - risk-factors

KW - follow-up

KW - allergen sensitization

U2 - 10.1016/S0140-6736(08)61451-8

DO - 10.1016/S0140-6736(08)61451-8

M3 - Literature review

VL - 372

SP - 1100

EP - 1106

JO - The Lancet

JF - The Lancet

SN - 0140-6736

IS - 9643

ER -

Early identification of atopy in the prediction of persistent asthma in children

Abstract

Keywords

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