Abstract
Context
There have been many reports confirming the association between lower childhood socioeconomic circumstance and cardiovascular disease but evidence for links with cerebrovascular disease is contradictory. Hyperintensities on brain magnetic resonance imaging are associated with vascular risk factors, cognitive decline, dementia and death. However, the relationship between childhood socioeconomic circumstance and these lesions is unclear.
Objective
To test the hypothesis that childhood socioeconomic circumstance is associated with late life hyperintensity burden and that neither adult socioeconomic circumstance nor change in socioeconomic circumstance during life influence this effect.
Design
Cohort study
Setting
Community
Participants
227 community dwelling members of the 1936 Aberdeen Birth Cohort aged 68 years, who were free from dementia.
Main Outcome Measures
Relationship between early life socioeconomic circumstance (paternal occupation) and abundance of late life brain hyperintensities.
There have been many reports confirming the association between lower childhood socioeconomic circumstance and cardiovascular disease but evidence for links with cerebrovascular disease is contradictory. Hyperintensities on brain magnetic resonance imaging are associated with vascular risk factors, cognitive decline, dementia and death. However, the relationship between childhood socioeconomic circumstance and these lesions is unclear.
Objective
To test the hypothesis that childhood socioeconomic circumstance is associated with late life hyperintensity burden and that neither adult socioeconomic circumstance nor change in socioeconomic circumstance during life influence this effect.
Design
Cohort study
Setting
Community
Participants
227 community dwelling members of the 1936 Aberdeen Birth Cohort aged 68 years, who were free from dementia.
Main Outcome Measures
Relationship between early life socioeconomic circumstance (paternal occupation) and abundance of late life brain hyperintensities.
| Original language | English |
|---|---|
| Article number | e88969 |
| Number of pages | 7 |
| Journal | PloS ONE |
| Volume | 9 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 18 Feb 2014 |
Bibliographical note
Funding:Image acquisition and image analysis for this study was funded by the Alzheimer's Research Trust (now Alzheimer's Research UK). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Acknowledgments
The authors would like to thank the participants of the Aberdeen 1936 Birth Cohort (ABC36), without whom this research would not have been possible.
Access to Document
- Murray AD et al cSEC & WHM PONE 2014 (1)
© 2014 Murray et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. https://creativecommons.org/licenses/by/4.0/
Fingerprint
Dive into the research topics of 'Early Life Socioeconomic Circumstance and Late Life Brain Hyperintensities: A Population Based Cohort Study'. Together they form a unique fingerprint.Datasets
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Aberdeen Birth Cohort Study 1936 (ABC 1936)
Craig, L. (Data Manager), University of Aberdeen, 1997
http://www.abdn.ac.uk/aberdeen-birth-cohort/ and one more link, https://www.abdn.ac.uk/birth-cohorts/1936/for-researchers/data-access/?action=subpage (show fewer)
Dataset
Profiles
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Christopher McNeil
- School of Medicine, Medical Sciences & Nutrition, Applied Medicine - Research Fellow
- School of Medicine, Medical Sciences & Nutrition, Aberdeen Biomedical Imaging Centre
Person: Academic Related - Research