Early Life Socioeconomic Circumstance and Late Life Brain Hyperintensities: A Population Based Cohort Study

Alison D Murray; Christopher J McNeil; Sima Salarirad; Lawrence J Whalley; Roger T Staff

doi:10.1371/journal.pone.0088969

Early Life Socioeconomic Circumstance and Late Life Brain Hyperintensities: A Population Based Cohort Study

Alison D Murray^* (Corresponding Author), Christopher J McNeil, Sima Salarirad, Lawrence J Whalley, Roger T Staff

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

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Abstract

Context
There have been many reports confirming the association between lower childhood socioeconomic circumstance and cardiovascular disease but evidence for links with cerebrovascular disease is contradictory. Hyperintensities on brain magnetic resonance imaging are associated with vascular risk factors, cognitive decline, dementia and death. However, the relationship between childhood socioeconomic circumstance and these lesions is unclear.

Objective
To test the hypothesis that childhood socioeconomic circumstance is associated with late life hyperintensity burden and that neither adult socioeconomic circumstance nor change in socioeconomic circumstance during life influence this effect.

Design
Cohort study

Setting
Community

Participants
227 community dwelling members of the 1936 Aberdeen Birth Cohort aged 68 years, who were free from dementia.

Main Outcome Measures
Relationship between early life socioeconomic circumstance (paternal occupation) and abundance of late life brain hyperintensities.

Original language	English
Article number	e88969
Number of pages	7
Journal	PloS ONE
Volume	9
Issue number	2
DOIs	https://doi.org/10.1371/journal.pone.0088969
Publication status	Published - 18 Feb 2014

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10.1371/journal.pone.0088969Licence: CC BY

Murray AD et al cSEC & WHM PONE 2014 (1)
© 2014 Murray et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. https://creativecommons.org/licenses/by/4.0/
Final published version, 442 KBLicence: CC BY

Aberdeen Birth Cohort Study 1936 (ABC 1936)
Craig, L. (Data Manager), University of Aberdeen, 1997
http://www.abdn.ac.uk/aberdeen-birth-cohort/ and one more link, https://www.abdn.ac.uk/birth-cohorts/1936/for-researchers/data-access/?action=subpage (show fewer)
Dataset

Christopher McNeil
Person: Academic Related - Research

Cite this

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title = "Early Life Socioeconomic Circumstance and Late Life Brain Hyperintensities: A Population Based Cohort Study",

abstract = "ContextThere have been many reports confirming the association between lower childhood socioeconomic circumstance and cardiovascular disease but evidence for links with cerebrovascular disease is contradictory. Hyperintensities on brain magnetic resonance imaging are associated with vascular risk factors, cognitive decline, dementia and death. However, the relationship between childhood socioeconomic circumstance and these lesions is unclear.ObjectiveTo test the hypothesis that childhood socioeconomic circumstance is associated with late life hyperintensity burden and that neither adult socioeconomic circumstance nor change in socioeconomic circumstance during life influence this effect.DesignCohort studySettingCommunityParticipants227 community dwelling members of the 1936 Aberdeen Birth Cohort aged 68 years, who were free from dementia.Main Outcome MeasuresRelationship between early life socioeconomic circumstance (paternal occupation) and abundance of late life brain hyperintensities.",

author = "Murray, {Alison D} and McNeil, {Christopher J} and Sima Salarirad and Whalley, {Lawrence J} and Staff, {Roger T}",

note = "Funding: Image acquisition and image analysis for this study was funded by the Alzheimer's Research Trust (now Alzheimer's Research UK). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Acknowledgments The authors would like to thank the participants of the Aberdeen 1936 Birth Cohort (ABC36), without whom this research would not have been possible.",

year = "2014",

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doi = "10.1371/journal.pone.0088969",

language = "English",

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T2 - A Population Based Cohort Study

AU - Murray, Alison D

AU - McNeil, Christopher J

AU - Salarirad, Sima

AU - Whalley, Lawrence J

AU - Staff, Roger T

N1 - Funding: Image acquisition and image analysis for this study was funded by the Alzheimer's Research Trust (now Alzheimer's Research UK). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Acknowledgments The authors would like to thank the participants of the Aberdeen 1936 Birth Cohort (ABC36), without whom this research would not have been possible.

PY - 2014/2/18

Y1 - 2014/2/18

N2 - ContextThere have been many reports confirming the association between lower childhood socioeconomic circumstance and cardiovascular disease but evidence for links with cerebrovascular disease is contradictory. Hyperintensities on brain magnetic resonance imaging are associated with vascular risk factors, cognitive decline, dementia and death. However, the relationship between childhood socioeconomic circumstance and these lesions is unclear.ObjectiveTo test the hypothesis that childhood socioeconomic circumstance is associated with late life hyperintensity burden and that neither adult socioeconomic circumstance nor change in socioeconomic circumstance during life influence this effect.DesignCohort studySettingCommunityParticipants227 community dwelling members of the 1936 Aberdeen Birth Cohort aged 68 years, who were free from dementia.Main Outcome MeasuresRelationship between early life socioeconomic circumstance (paternal occupation) and abundance of late life brain hyperintensities.

AB - ContextThere have been many reports confirming the association between lower childhood socioeconomic circumstance and cardiovascular disease but evidence for links with cerebrovascular disease is contradictory. Hyperintensities on brain magnetic resonance imaging are associated with vascular risk factors, cognitive decline, dementia and death. However, the relationship between childhood socioeconomic circumstance and these lesions is unclear.ObjectiveTo test the hypothesis that childhood socioeconomic circumstance is associated with late life hyperintensity burden and that neither adult socioeconomic circumstance nor change in socioeconomic circumstance during life influence this effect.DesignCohort studySettingCommunityParticipants227 community dwelling members of the 1936 Aberdeen Birth Cohort aged 68 years, who were free from dementia.Main Outcome MeasuresRelationship between early life socioeconomic circumstance (paternal occupation) and abundance of late life brain hyperintensities.

U2 - 10.1371/journal.pone.0088969

DO - 10.1371/journal.pone.0088969

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SN - 1932-6203

IS - 2

M1 - e88969

ER -

Early Life Socioeconomic Circumstance and Late Life Brain Hyperintensities: A Population Based Cohort Study

Abstract

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Datasets

Aberdeen Birth Cohort Study 1936 (ABC 1936)

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Christopher McNeil

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