Early life socioeconomic circumstances and late life brain hyperintensities: a population based cohort study

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Abstract

Context
There have been many reports confirming the association between lower childhood socioeconomic circumstance and cardiovascular disease but evidence for links with cerebrovascular disease is contradictory. Hyperintensities on brain magnetic resonance imaging are associated with vascular risk factors, cognitive decline, dementia and death. However, the relationship between childhood socioeconomic circumstance and these lesions is unclear.

Objective
To test the hypothesis that childhood socioeconomic circumstance is associated with late life hyperintensity burden and that neither adult socioeconomic circumstance nor change in socioeconomic circumstance during life influence this effect.

Design
Cohort study

Setting
Community

Participants
227 community dwelling members of the 1936 Aberdeen Birth Cohort aged 68 years, who were free from dementia.

Main Outcome Measures
Relationship between early life socioeconomic circumstance (paternal occupation) and abundance of late life brain hyperintensities.

Original languageEnglish
Article numbere88969
Number of pages7
JournalPloS ONE
Volume9
Issue number2
DOIs
Publication statusPublished - 18 Feb 2014

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