Early life socioeconomic circumstances and late life brain hyperintensities

a population based cohort study

Research output: Contribution to journalArticle

15 Citations (Scopus)
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Abstract

Context
There have been many reports confirming the association between lower childhood socioeconomic circumstance and cardiovascular disease but evidence for links with cerebrovascular disease is contradictory. Hyperintensities on brain magnetic resonance imaging are associated with vascular risk factors, cognitive decline, dementia and death. However, the relationship between childhood socioeconomic circumstance and these lesions is unclear.

Objective
To test the hypothesis that childhood socioeconomic circumstance is associated with late life hyperintensity burden and that neither adult socioeconomic circumstance nor change in socioeconomic circumstance during life influence this effect.

Design
Cohort study

Setting
Community

Participants
227 community dwelling members of the 1936 Aberdeen Birth Cohort aged 68 years, who were free from dementia.

Main Outcome Measures
Relationship between early life socioeconomic circumstance (paternal occupation) and abundance of late life brain hyperintensities.

Original languageEnglish
Article numbere88969
Number of pages7
JournalPloS ONE
Volume9
Issue number2
DOIs
Publication statusPublished - 18 Feb 2014

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cohort studies
socioeconomics
Brain
Cohort Studies
brain
Magnetic resonance
childhood
Population
Dementia
dementia
Independent Living
Imaging techniques
Cerebrovascular Disorders
Occupations
cerebrovascular disorders
Cardiovascular Diseases
Magnetic Resonance Imaging
Parturition
magnetic resonance imaging
blood vessels

Cite this

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title = "Early life socioeconomic circumstances and late life brain hyperintensities: a population based cohort study",
abstract = "ContextThere have been many reports confirming the association between lower childhood socioeconomic circumstance and cardiovascular disease but evidence for links with cerebrovascular disease is contradictory. Hyperintensities on brain magnetic resonance imaging are associated with vascular risk factors, cognitive decline, dementia and death. However, the relationship between childhood socioeconomic circumstance and these lesions is unclear.ObjectiveTo test the hypothesis that childhood socioeconomic circumstance is associated with late life hyperintensity burden and that neither adult socioeconomic circumstance nor change in socioeconomic circumstance during life influence this effect.DesignCohort studySettingCommunityParticipants227 community dwelling members of the 1936 Aberdeen Birth Cohort aged 68 years, who were free from dementia.Main Outcome MeasuresRelationship between early life socioeconomic circumstance (paternal occupation) and abundance of late life brain hyperintensities.",
author = "Murray, {Alison D} and McNeil, {Christopher J} and Sima Salarirad and Whalley, {Lawrence J} and Staff, {Roger T}",
year = "2014",
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T1 - Early life socioeconomic circumstances and late life brain hyperintensities

T2 - a population based cohort study

AU - Murray, Alison D

AU - McNeil, Christopher J

AU - Salarirad, Sima

AU - Whalley, Lawrence J

AU - Staff, Roger T

PY - 2014/2/18

Y1 - 2014/2/18

N2 - ContextThere have been many reports confirming the association between lower childhood socioeconomic circumstance and cardiovascular disease but evidence for links with cerebrovascular disease is contradictory. Hyperintensities on brain magnetic resonance imaging are associated with vascular risk factors, cognitive decline, dementia and death. However, the relationship between childhood socioeconomic circumstance and these lesions is unclear.ObjectiveTo test the hypothesis that childhood socioeconomic circumstance is associated with late life hyperintensity burden and that neither adult socioeconomic circumstance nor change in socioeconomic circumstance during life influence this effect.DesignCohort studySettingCommunityParticipants227 community dwelling members of the 1936 Aberdeen Birth Cohort aged 68 years, who were free from dementia.Main Outcome MeasuresRelationship between early life socioeconomic circumstance (paternal occupation) and abundance of late life brain hyperintensities.

AB - ContextThere have been many reports confirming the association between lower childhood socioeconomic circumstance and cardiovascular disease but evidence for links with cerebrovascular disease is contradictory. Hyperintensities on brain magnetic resonance imaging are associated with vascular risk factors, cognitive decline, dementia and death. However, the relationship between childhood socioeconomic circumstance and these lesions is unclear.ObjectiveTo test the hypothesis that childhood socioeconomic circumstance is associated with late life hyperintensity burden and that neither adult socioeconomic circumstance nor change in socioeconomic circumstance during life influence this effect.DesignCohort studySettingCommunityParticipants227 community dwelling members of the 1936 Aberdeen Birth Cohort aged 68 years, who were free from dementia.Main Outcome MeasuresRelationship between early life socioeconomic circumstance (paternal occupation) and abundance of late life brain hyperintensities.

U2 - 10.1371/journal.pone.0088969

DO - 10.1371/journal.pone.0088969

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VL - 9

JO - PloS ONE

JF - PloS ONE

SN - 1932-6203

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