Early-onset Alzheimer's disease in Scotland: environmental and familial factors

Lawrence Jeffrey Whalley

Research output: Contribution to journalEditorial

18 Citations (Scopus)

Abstract

Background Alzheimer's disease (AD) is a common, complex, age-related disorder in which both genetic and environmental factors are important.
Aims To integrate recent studies on genetic and environmental factors in AD into a multi-factorial disease model.
Method Disease models to explain gene—environment interaction in cardiovascular disease are related to observations on AD.
Results Informative, communitybased studies on the genetic epidemiology of AD are rare. Putative risk factors from the Scottish studies include increased paternal age in AD men and coal mining as paternal occupation in both AD and vascular dementia. Migration effects suggest that environmental factors in high-incidence AD areas are important during adult life.
Conclusions The studies summarised do not provide sufficient data to support a single comprehensive disease model of gene—environment interaction in AD. Future studies will require very large ( 600) sample sizes, molecular genetic analysis, and environmental data that span neurodevelopment and the period between disease onset and appearance of clinical symptoms.
Original languageEnglish
Pages (from-to)s53-9
Number of pages7
JournalBritish Journal of Psychiatry - Supplement
Volume178
Issue numberSupplement 40
DOIs
Publication statusPublished - 2001

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Scotland
Alzheimer Disease
Coal Mining
Paternal Age
Vascular Dementia
Molecular Epidemiology
Occupations
Sample Size
Molecular Biology
Cardiovascular Diseases
Incidence

Cite this

Early-onset Alzheimer's disease in Scotland: environmental and familial factors. / Whalley, Lawrence Jeffrey.

In: British Journal of Psychiatry - Supplement, Vol. 178, No. Supplement 40, 2001, p. s53-9.

Research output: Contribution to journalEditorial

Whalley, Lawrence Jeffrey. / Early-onset Alzheimer's disease in Scotland: environmental and familial factors. In: British Journal of Psychiatry - Supplement. 2001 ; Vol. 178, No. Supplement 40. pp. s53-9.
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