Early ovarian ageing: a hypothesis. Detection and clinical relevance

Research output: Contribution to journalArticle

131 Citations (Scopus)

Abstract

An important scientific breakthrough of the 20th century, IVF helped open new horizons in medicine, such as preimplantation genetic diagnosis and embryonic stem-cell therapy. A further contribution of assisted reproduction technology has been the better understanding of reproductive ageing. Data from IVF cycles suggest that there is a fixed time-interval between accelerated decline of fertility and the menopause. This leads to the hypothesis that a significant proportion of asymptomatic women in the early thirties may be at risk of early onset of subfertility. IVF provides a model for the development of ovarian reserve tests, some of which appear promising as potential screening tools for early ovarian ageing in the general population.

Original languageEnglish
Pages (from-to)1137-1139
Number of pages2
JournalHuman Reproduction
Volume18
Issue number6
DOIs
Publication statusPublished - 2003

Keywords

  • IVF
  • ovarian ageing
  • screening
  • IN-VITRO FERTILIZATION
  • FOLLICLE-STIMULATING-HORMONE
  • CITRATE CHALLENGE TEST
  • NATURAL MENOPAUSE
  • DOWNS-SYNDROME
  • POOR RESPONSE
  • FRAGILE-X
  • WOMEN
  • INFERTILITY
  • RESERVE

Cite this

Early ovarian ageing: a hypothesis. Detection and clinical relevance. / Nikolaou, D.; Templeton, Alexander Allan.

In: Human Reproduction, Vol. 18, No. 6, 2003, p. 1137-1139.

Research output: Contribution to journalArticle

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