Early phytocannabinoid chemistry to endocannabinoids and beyond

Raphael Mechoulam*, Lumir O. Hanus, Roger Pertwee, Allyn C. Howlett

*Corresponding author for this work

Research output: Contribution to journalArticle

107 Citations (Scopus)

Abstract

Isolation and structure elucidation of most of the major cannabinoid constituents-including Delta(9)-tetrahydrocannabinol (Delta(9)-THC), which is the principal psychoactive molecule in Cannabis sativa-was achieved in the 1960s and 1970s. It was followed by the identification of two cannabinoid receptors in the 1980s and the early 1990s and by the identification of the endocannabinoids shortly thereafter. There have since been considerable advances in our understanding of the endocannabinoid system and its function in the brain, which reveal potential therapeutic targets for a wide range of brain disorders.

Original languageEnglish
Pages (from-to)757-764
Number of pages8
JournalNature reviews neuroscience
Volume15
Issue number11
Early online date15 Oct 2014
DOIs
Publication statusPublished - Nov 2014

Cite this

Early phytocannabinoid chemistry to endocannabinoids and beyond. / Mechoulam, Raphael; Hanus, Lumir O.; Pertwee, Roger; Howlett, Allyn C.

In: Nature reviews neuroscience, Vol. 15, No. 11, 11.2014, p. 757-764.

Research output: Contribution to journalArticle

Mechoulam, Raphael ; Hanus, Lumir O. ; Pertwee, Roger ; Howlett, Allyn C. / Early phytocannabinoid chemistry to endocannabinoids and beyond. In: Nature reviews neuroscience. 2014 ; Vol. 15, No. 11. pp. 757-764.
@article{fdaf3ce2250a4b33ba061a262383bc43,
title = "Early phytocannabinoid chemistry to endocannabinoids and beyond",
abstract = "Isolation and structure elucidation of most of the major cannabinoid constituents-including Delta(9)-tetrahydrocannabinol (Delta(9)-THC), which is the principal psychoactive molecule in Cannabis sativa-was achieved in the 1960s and 1970s. It was followed by the identification of two cannabinoid receptors in the 1980s and the early 1990s and by the identification of the endocannabinoids shortly thereafter. There have since been considerable advances in our understanding of the endocannabinoid system and its function in the brain, which reveal potential therapeutic targets for a wide range of brain disorders.",
author = "Raphael Mechoulam and Hanus, {Lumir O.} and Roger Pertwee and Howlett, {Allyn C.}",
year = "2014",
month = "11",
doi = "10.1038/nrn3811",
language = "English",
volume = "15",
pages = "757--764",
journal = "Nature reviews neuroscience",
issn = "1471-003X",
publisher = "NATURE PUBLISHING GROUP",
number = "11",

}

TY - JOUR

T1 - Early phytocannabinoid chemistry to endocannabinoids and beyond

AU - Mechoulam, Raphael

AU - Hanus, Lumir O.

AU - Pertwee, Roger

AU - Howlett, Allyn C.

PY - 2014/11

Y1 - 2014/11

N2 - Isolation and structure elucidation of most of the major cannabinoid constituents-including Delta(9)-tetrahydrocannabinol (Delta(9)-THC), which is the principal psychoactive molecule in Cannabis sativa-was achieved in the 1960s and 1970s. It was followed by the identification of two cannabinoid receptors in the 1980s and the early 1990s and by the identification of the endocannabinoids shortly thereafter. There have since been considerable advances in our understanding of the endocannabinoid system and its function in the brain, which reveal potential therapeutic targets for a wide range of brain disorders.

AB - Isolation and structure elucidation of most of the major cannabinoid constituents-including Delta(9)-tetrahydrocannabinol (Delta(9)-THC), which is the principal psychoactive molecule in Cannabis sativa-was achieved in the 1960s and 1970s. It was followed by the identification of two cannabinoid receptors in the 1980s and the early 1990s and by the identification of the endocannabinoids shortly thereafter. There have since been considerable advances in our understanding of the endocannabinoid system and its function in the brain, which reveal potential therapeutic targets for a wide range of brain disorders.

U2 - 10.1038/nrn3811

DO - 10.1038/nrn3811

M3 - Article

VL - 15

SP - 757

EP - 764

JO - Nature reviews neuroscience

JF - Nature reviews neuroscience

SN - 1471-003X

IS - 11

ER -