Early regulation of hypothalamic arcuate nucleus CART gene expression by short photoperiod in the Siberian hamster

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Abstract

Cocaine- and amphetamine-regulated transcript (CART) mRNA is expressed in a number of hypothalamic nuclei including the arcuate nucleus (ARC). An increase in CART gene expression in the ARC of juvenile female Siberian hamsters (Phodopus sungorus) 14 days after transfer to short photoperiod at weaning and prior to major divergence of body weight trajectory in this seasonal mammal implicates CART in the induction of programmed weight change. In the current series of experiments, elevated CART mRNA in short photoperiod juvenile female animals relative to long photoperiod controls was apparent throughout the caudal-rostral extent of the ARC after 14 days, but was not observed when short photoperiod exposure was limited to 4-7 days. Elevated CART gene expression was also observed in juvenile males 14 days after transfer to short photoperiod at weaning, in adult female hamsters 14 days after transfer to short photoperiod and in adult male hamsters 21 days after transfer to short photoperiod. There were no consistent trends in expression levels of other energy balance-related genes with these relatively short duration photoperiod manipulations, suggesting that CART may be involved in short photoperiod-programmed body weight regulation. (C) 2002 Elsevier Science B.V. All rights reserved.

Original languageEnglish
Pages (from-to)129-136
Number of pages8
JournalRegulatory Peptides
Volume111
Issue number1-3
Early online date15 Jan 2003
DOIs
Publication statusPublished - 28 Mar 2003

Keywords

  • body weight
  • Phodopus sungorus
  • seasonal
  • cocaine- and amphetamine-regulated transcript
  • neuropeptide
  • BODY-WEIGHT
  • FOOD-INTAKE
  • NERVOUS-SYSTEM
  • MESSENGER-RNA
  • TRANSCRIPT
  • COCAINE
  • NEUROPEPTIDE
  • OBESITY
  • LEPTIN
  • NPY
  • Body weight
  • Seasonal
  • Cocaine- and amphetamine-regulated transcript
  • Neuropeptide

Cite this

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title = "Early regulation of hypothalamic arcuate nucleus CART gene expression by short photoperiod in the Siberian hamster",
abstract = "Cocaine- and amphetamine-regulated transcript (CART) mRNA is expressed in a number of hypothalamic nuclei including the arcuate nucleus (ARC). An increase in CART gene expression in the ARC of juvenile female Siberian hamsters (Phodopus sungorus) 14 days after transfer to short photoperiod at weaning and prior to major divergence of body weight trajectory in this seasonal mammal implicates CART in the induction of programmed weight change. In the current series of experiments, elevated CART mRNA in short photoperiod juvenile female animals relative to long photoperiod controls was apparent throughout the caudal-rostral extent of the ARC after 14 days, but was not observed when short photoperiod exposure was limited to 4-7 days. Elevated CART gene expression was also observed in juvenile males 14 days after transfer to short photoperiod at weaning, in adult female hamsters 14 days after transfer to short photoperiod and in adult male hamsters 21 days after transfer to short photoperiod. There were no consistent trends in expression levels of other energy balance-related genes with these relatively short duration photoperiod manipulations, suggesting that CART may be involved in short photoperiod-programmed body weight regulation. (C) 2002 Elsevier Science B.V. All rights reserved.",
keywords = "body weight, Phodopus sungorus, seasonal, cocaine- and amphetamine-regulated transcript, neuropeptide, BODY-WEIGHT, FOOD-INTAKE, NERVOUS-SYSTEM, MESSENGER-RNA, TRANSCRIPT, COCAINE, NEUROPEPTIDE, OBESITY, LEPTIN, NPY, Body weight, Seasonal, Cocaine- and amphetamine-regulated transcript, Neuropeptide",
author = "Julian Mercer and C Ellis and Kim-Marie Moar and Tracy Logie and Morgan, {Peter John} and Adam, {Clare Lesley}",
year = "2003",
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doi = "10.1016/S0167-0115(02)00263-X",
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T1 - Early regulation of hypothalamic arcuate nucleus CART gene expression by short photoperiod in the Siberian hamster

AU - Mercer, Julian

AU - Ellis, C

AU - Moar, Kim-Marie

AU - Logie, Tracy

AU - Morgan, Peter John

AU - Adam, Clare Lesley

PY - 2003/3/28

Y1 - 2003/3/28

N2 - Cocaine- and amphetamine-regulated transcript (CART) mRNA is expressed in a number of hypothalamic nuclei including the arcuate nucleus (ARC). An increase in CART gene expression in the ARC of juvenile female Siberian hamsters (Phodopus sungorus) 14 days after transfer to short photoperiod at weaning and prior to major divergence of body weight trajectory in this seasonal mammal implicates CART in the induction of programmed weight change. In the current series of experiments, elevated CART mRNA in short photoperiod juvenile female animals relative to long photoperiod controls was apparent throughout the caudal-rostral extent of the ARC after 14 days, but was not observed when short photoperiod exposure was limited to 4-7 days. Elevated CART gene expression was also observed in juvenile males 14 days after transfer to short photoperiod at weaning, in adult female hamsters 14 days after transfer to short photoperiod and in adult male hamsters 21 days after transfer to short photoperiod. There were no consistent trends in expression levels of other energy balance-related genes with these relatively short duration photoperiod manipulations, suggesting that CART may be involved in short photoperiod-programmed body weight regulation. (C) 2002 Elsevier Science B.V. All rights reserved.

AB - Cocaine- and amphetamine-regulated transcript (CART) mRNA is expressed in a number of hypothalamic nuclei including the arcuate nucleus (ARC). An increase in CART gene expression in the ARC of juvenile female Siberian hamsters (Phodopus sungorus) 14 days after transfer to short photoperiod at weaning and prior to major divergence of body weight trajectory in this seasonal mammal implicates CART in the induction of programmed weight change. In the current series of experiments, elevated CART mRNA in short photoperiod juvenile female animals relative to long photoperiod controls was apparent throughout the caudal-rostral extent of the ARC after 14 days, but was not observed when short photoperiod exposure was limited to 4-7 days. Elevated CART gene expression was also observed in juvenile males 14 days after transfer to short photoperiod at weaning, in adult female hamsters 14 days after transfer to short photoperiod and in adult male hamsters 21 days after transfer to short photoperiod. There were no consistent trends in expression levels of other energy balance-related genes with these relatively short duration photoperiod manipulations, suggesting that CART may be involved in short photoperiod-programmed body weight regulation. (C) 2002 Elsevier Science B.V. All rights reserved.

KW - body weight

KW - Phodopus sungorus

KW - seasonal

KW - cocaine- and amphetamine-regulated transcript

KW - neuropeptide

KW - BODY-WEIGHT

KW - FOOD-INTAKE

KW - NERVOUS-SYSTEM

KW - MESSENGER-RNA

KW - TRANSCRIPT

KW - COCAINE

KW - NEUROPEPTIDE

KW - OBESITY

KW - LEPTIN

KW - NPY

KW - Body weight

KW - Seasonal

KW - Cocaine- and amphetamine-regulated transcript

KW - Neuropeptide

U2 - 10.1016/S0167-0115(02)00263-X

DO - 10.1016/S0167-0115(02)00263-X

M3 - Article

VL - 111

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JO - Regulatory Peptides

JF - Regulatory Peptides

SN - 0167-0115

IS - 1-3

ER -